NEET MDS Synopsis
Gross Features of the Tongue
AnatomyGross Features of the Tongue
The dorsum of the tongue is divided by a V-shaped sulcus terminalis into anterior oral (presulcal) and posterior pharyngeal (postsulcal) parts.
The apex of the V is posterior and the two limbs diverge anteriorly.
The oral part forms about 2/3 of the tongue and the pharyngeal part forms about 1/3.
Oral Part of the Tongue
This part is freely movable, but it is loosely attached to the floor of the mouth by the lingual frenulum.
On each side of the frenulum is a deep lingual vein, visible as a blue line.
It begins at the tip of the tongue and runs posteriorly.
All the veins on one side of the tongue unite at the posterior border of the hyoglossus muscle to form the lingual vein, which joins the facial vein or the internal jugular vein.
On the dorsum of the oral part of the tongue is a median groove.
This groove represents the site of fusion of the distal tongue buds during embryonic development.
The Lingual Papillae and Taste Buds
The filiform papillae (L. filum, thread) are numerous, rough, and thread-like.
They are arranged in rows parallel to the sulcus terminalis.
The fungiform papillae are small and mushroom-shaped.
They usually appear are pink or red spots.
The vallate (circumvallate) papillae are surrounded by a deep, circular trench (trough), the walls of which are studded with taste buds.
The foliate papillae are small lateral folds of lingual mucosa that are poorly formed in humans.
The vallate, foliate and most of the fungiform papillae contain taste receptors, which are located in the taste buds.
The Pharyngeal Part of the Tongue
This part lies posterior to the sulcus terminalis and palatoglossal arches.
Its mucous membrane has no papillae.
The underlying nodules of lymphoid tissue give this part of the tongue a cobblestone appearance.
The lymphoid nodules (lingual follicles) are collectively known as the lingual tonsil.
Fiberoptic Endotracheal Intubation
Oral and Maxillofacial SurgeryFiberoptic Endotracheal Intubation
Fiberoptic endotracheal intubation is a valuable technique
in airway management, particularly in situations where traditional intubation
methods may be challenging or impossible. This technique utilizes a flexible
fiberoptic scope to visualize the airway and facilitate the placement of an
endotracheal tube. Below is an overview of the indications, techniques, and
management strategies for both basic and difficult airway situations.
Indications for Fiberoptic Intubation
Cervical Spine Stability:
Useful in patients with unstable cervical spine injuries where neck
manipulation is contraindicated.
Poor Visualization of Vocal Cords:
When a straight line view from the mouth to the larynx cannot be
established, fiberoptic intubation allows for visualization of the vocal
cords through the nasal or oral route.
Difficult Airway:
Can be performed as an initial management strategy for patients
known to have a difficult airway or as a backup technique if direct
laryngoscopy fails.
Awake Intubation:
Fiberoptic intubation can be performed while the patient is awake,
allowing for better tolerance and cooperation, especially in cases of
anticipated difficult intubation.
Basic Airway Management
Basic airway management involves the following components:
Airway Anatomy and Evaluation: Understanding the anatomy
of the airway and assessing the patient's airway for potential difficulties.
Mask Ventilation: Techniques for providing positive
pressure ventilation using a bag-mask device.
Oropharyngeal and Nasal Airways: Use of adjuncts to
maintain airway patency.
Direct Laryngoscopy and Intubation: Standard technique
for intubating the trachea using a laryngoscope.
Laryngeal Mask Airway (LMA) Placement: An alternative
airway device that can be used when intubation is not possible.
Indications, Contraindications, and Management of Complications:
Understanding when to use each technique and how to manage potential
complications.
Objective Structured Clinical Evaluation (OSCE): A
method for assessing the skills of trainees in airway management.
Evaluation of Session by Trainees: Feedback and
assessment of the training session to improve skills and knowledge.
Difficult Airway Management
Difficult airway management requires a systematic approach, often guided by
an algorithm. Key components include:
Difficult Airway Algorithm: A step-by-step approach to
managing difficult airways, including decision points for intervention.
Airway Anesthesia: Techniques for anesthetizing the
airway to facilitate intubation, especially in awake intubation scenarios.
Fiberoptic Intubation: As previously discussed, this
technique is crucial for visualizing and intubating the trachea in difficult
cases.
Intubation with Fastrach and CTrach LMA: Specialized
LMAs designed for facilitating intubation.
Intubation with Shikhani Optical Stylet and Light Wand:
Tools that assist in visualizing the airway and guiding the endotracheal
tube.
Cricothyrotomy and Jet Ventilation: Emergency procedures
for establishing an airway when intubation is not possible.
Combitube: A dual-lumen airway device that can be used
in emergencies.
Intubation Over Bougie: A technique that uses a bougie
to facilitate intubation when direct visualization is difficult.
Retrograde Wire Intubation: A method that involves
passing a wire through the cricothyroid membrane to guide the endotracheal
tube.
Indications, Contraindications, and Management of Complications:
Understanding when to use each technique and how to manage complications
effectively.
Objective Structured Clinical Evaluation (OSCE):
Assessment of trainees' skills in managing difficult airways.
Evaluation of Session by Trainees: Feedback and
assessment to enhance learning and skill development.
The Sprue
Dental Materials
The Sprue :
Its a channel through which molten alloy can reach the mold in an invested ring after the wax has been eliminated. Role of a Sprue: Create a channel to allow the molten wax to escape from the mold. Enable the molten alloy to flow into the mold which was previously occupied by the wax pattern.
FUNCTIONS OF SPRUE
1 . Forms a mount for the wax pattern .
2 . Creates a channel for elimination of wax .
3 .Forms a channel for entry of molten metal
4 . Provides a reservoir of molten metal to compensate for the alloy shrinkage .
SELECTION OF SPRUE
Sprue former gauge selection is often empirical, is yet based on the following five general principles:
1. Select the gauge sprue former with a diameter that is approximately the same size as the thickest area of the wax pattern. If the pattern is small, the sprue former must also be small because a large sprue former attached to a thin delicate pattern could cause distortion. However if the sprue former diameter is too small this area will solidify before the casting itself and localized shrinkage porosity may result.
2. If possible the sprue former should be attached to the portion of the pattern with the largest cross-sectional area. It is best for the molten alloy to flow from the thick section to the surrounding thin areas. This design minimizes the risk of turbulence.
3. The length of the sprue former should be long enough to properly position the pattern in the casting ring within 6mm of the trailing end and yet short enough so the molten alloy does not solidify before it fills the mold.
4. The type of sprue former selected influences the burnout technique used. It is advisable to use a two-stage burnout technique whenever plastic sprue formers or patterns are involved to ensure complete carbon elimination, because plastic sprues soften at temperatures above the melting point of the inlay waxes.
5. Patterns may be sprued directly or indirectly. For direct sprueing the sprue former provides the direct connection between the pattern area and the sprue base or crucible former area. With indirect spruing a connector or reservoir bar is positioned between the pattern and the crucible former. It is common to use indirect spruing for multiple stage units and fixed partial dentures.
Ketone Body
Biochemistry
During fasting or carbohydrate starvation, oxaloacetate is depleted in liver because it is used for gluconeogenesis. This impedes entry of acetyl-CoA into Krebs cycle. Acetyl-CoA then is converted in liver mitochondria to ketone bodies, acetoacetate and b-hydroxybutyrate.
Three enzymes are involved in synthesis of ketone bodies:
b-Ketothiolase. The final step of the b-oxidation pathway runs backwards, condensing 2 acetyl-CoA to produce acetoacetyl-CoA, with release of one CoA.
HMG-CoA Synthase catalyzes condensation of a third acetate moiety (from acetyl-CoA) with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA).
HMG-CoA Lyase cleaves HMG-CoA to yield acetoacetate plus acetyl-CoA.
b-Hydroxybutyrate Dehydrogenase catalyzes inter-conversion of the ketone bodies acetoacetate and b-hydroxybutyrate.
Ketone bodies are transported in the blood to other tissue cells, where they are converted back to acetyl-CoA for catabolism in Krebs cycle
ERUPTION - Permanent teeth
Dental Anatomy
Permanent teeth
1. The permanent teeth begin formation between birth and 3 years of age (except for the third molars)
2. The crowns of permanent teeth are completed between 4 and 8 years of age, at approximately one- half the age of eruption
The sequence for permanent development
Maxillary
First molar → Central incisor → Lateral incisor → First premotar → Second pmmolar → Canine → Second molar → Third molar
Mandibular
First molar → Central incisor → Lateral incisor → Canine → First premolar → Second premolar → Second molar → Third molar
Permanent teeth emerge into the oral cavity as
Maxillary Mandibular
Central incisor 7-8 years 6-7 years
Lateral incisor 8-9 years 7-8 years
Canine 11-12 years 9-10 years
First premolar 10-Il years 10-12 years
Second premolar 10-12 years 11-12 years
First molar 6-7 years 6-7 years
Second molar 12-13 years 11-13 years
Third molar 17-21 years 17-21 years
The roots of the permanent teeth are completed between 10 and 16 years of age, 2 to 3 years after eruption
The small intestine
PhysiologyThe small intestine
Digestion within the small intestine produces a mixture of disaccharides, peptides, fatty acids, and monoglycerides. The final digestion and absorption of these substances occurs in the villi, which line the inner surface of the small intestine.
This scanning electron micrograph (courtesy of Keith R. Porter) shows the villi carpeting the inner surface of the small intestine.
The crypts at the base of the villi contain stem cells that continuously divide by mitosis producing
more stem cells
cells that migrate up the surface of the villus while differentiating into
columnar epithelial cells (the majority). They are responsible for digestion and absorption.
goblet cells, which secrete mucus;
endocrine cells, which secrete a variety of hormones;
Paneth cells, which secrete antimicrobial peptides that sterilize the contents of the intestine.
All of these cells replace older cells that continuously die by apoptosis.
The villi increase the surface area of the small intestine to many times what it would be if it were simply a tube with smooth walls. In addition, the apical (exposed) surface of the epithelial cells of each villus is covered with microvilli (also known as a "brush border"). Thanks largely to these, the total surface area of the intestine is almost 200 square meters, about the size of the singles area of a tennis court and some 100 times the surface area of the exterior of the body.
Incorporated in the plasma membrane of the microvilli are a number of enzymes that complete digestion:
aminopeptidases attack the amino terminal (N-terminal) of peptides producing amino acids.
disaccharidasesThese enzymes convert disaccharides into their monosaccharide subunits.
maltase hydrolyzes maltose into glucose.
sucrase hydrolyzes sucrose (common table sugar) into glucose and fructose.
lactase hydrolyzes lactose (milk sugar) into glucose and galactose.
Fructose simply diffuses into the villi, but both glucose and galactose are absorbed by active transport.
fatty acids and monoglycerides. These become resynthesized into fats as they enter the cells of the villus. The resulting small droplets of fat are then discharged by exocytosis into the lymph vessels, called lacteals, draining the villi.
Multiphase and Multistage random sampling
Public Health DentistryMultiphase and multistage random sampling are advanced
sampling techniques used in research, particularly in public health and social
sciences, to efficiently gather data from large and complex populations. Both
methods are designed to reduce costs and improve the feasibility of sampling
while maintaining the representativeness of the sample. Here’s a detailed
explanation of each method:
Multiphase Sampling
Description: Multiphase sampling involves conducting a
series of sampling phases, where each phase is used to refine the sample
further. This method is particularly useful when the population is large and
heterogeneous, and researchers want to focus on specific subgroups or
characteristics.
Process:
Initial Sampling: In the first phase, a large sample is
drawn from the entire population using a probability sampling method (e.g.,
simple random sampling or stratified sampling).
Subsequent Sampling: In the second phase, researchers
may apply additional criteria to select a smaller, more specific sample from
the initial sample. This could involve stratifying the sample based on
certain characteristics (e.g., age, health status) or conducting follow-up
surveys.
Data Collection: Data is collected from the final
sample, which is more targeted and relevant to the research question.
Applications:
Public Health Surveys: In a study assessing health
behaviors, researchers might first sample a broad population and then focus
on specific subgroups (e.g., smokers, individuals with chronic diseases) for
more detailed analysis.
Qualitative Research: Multiphase sampling can be used
to identify participants for in-depth interviews after an initial survey has
highlighted specific areas of interest.
Multistage Sampling
Description: Multistage sampling is a complex form of
sampling that involves selecting samples in multiple stages, often using a
combination of probability sampling methods. This technique is particularly
useful for large populations spread over wide geographic areas.
Process:
First Stage: The population is divided into clusters
(e.g., geographic areas, schools, or communities). A random sample of these
clusters is selected.
Second Stage: Within each selected cluster, a further
sampling method is applied to select individuals or smaller units. This
could involve simple random sampling, stratified sampling, or systematic
sampling.
Additional Stages: More stages can be added if
necessary, depending on the complexity of the population and the research
objectives.
Applications:
National Health Surveys: In a national health survey,
researchers might first randomly select states (clusters) and then randomly
select households within those states to gather health data.
Community Health Assessments: Multistage sampling can
be used to assess oral health in a large city by first selecting
neighborhoods and then sampling residents within those neighborhoods.
Key Differences
Structure:
Multiphase Sampling involves multiple phases of
sampling that refine the sample based on specific criteria, often
leading to a more focused subgroup.
Multistage Sampling involves multiple stages of
sampling, often starting with clusters and then selecting individuals
within those clusters.
Purpose:
Multiphase Sampling is typically used to narrow
down a broad sample to a more specific group for detailed study.
Multistage Sampling is used to manage large
populations and geographic diversity, making it easier to collect data
from a representative sample.
Megaloblastic anaemia
General Pathology
Megaloblastic anaemia
Metabolism: B12(cyanocobalamin) is a coenzyme in DNA synthesis and for maintenance of nervous system. Daily requirement 2 micro grams. Absorption in terminal ileum in the presence gastric intrinsic factor. It is stored in liver mainly-
Folic acid (Pteroylglutamic acid) is needed for DNA synthesis.. Daily requirement 100 micro grams. Absorption in duodenum and jejunum
Causes of deficiency .-
- Nutritional deficiency-
- Malabsorption syndrome.
- Pernicious anaemia (B12).
- Gastrectomy (B12).
- Fish tapeworm infestation (B12).
- Pregnancy and puerperium (Folic acid mainly).
- Myeloproliferative disorders (Folic acid).
- Malignancies (Folic acid).
- Drug induced (Folic-acid)
Features:
(i) Megaloblastic anaemia.
(ii) Glossitis.
(iii) Subacute combined degeneration (in B12deficiency).
Blood picture :
- Macrocytic normochromic anaemia.
- Anisocytosis and poikilocytosis with Howell-Jolly bodies and basophilic stippling.
- Occasional megalo blasts may be-seen.
- Neutropenia with hypersegmented neutrophills and macropolycytes.
- Thrombocytopenia.
- Increased MVC and MCH with normal or decreased MCHC.
Bone marrow:
- Megaloblasts are seen. They are larger with a more open stippled chromatin. The nuclear maturation lags behind. the cytoplasmic maturation. Maturation arrest is seen (more of early forms).
- Immature cells of granulocyte series are also larger.
-Giant stab forms (giant metamyelocytes).