NEET MDS Synopsis
Dentin
Dental Anatomy
Dentin
Composition: 70% inorganic, 20% organic, 10% water by weight and 45%, 33%, and 22% in volume respectively
Hydroxyapatite crystals and collagen type I
Physical characteristics: Harder than bone and softer than enamel
Yellow in color in normal teeth
Radiographic appearance: More radiolucent than enamel
Primary (circumpulpal) dentin: forms most of the tooth
Mantle dentin: first dentin to form; forms the outline of dentin in the adult tooth
Predentin: lines the innermost portion of dentin (faces the pulp)
Secondary dentin: after root formation dentin continues to form, continuous to primary dentin but with structural irregularities
Tertiary dentin: reactive or reparative dentin; may or may not have characteristics of primary dentin; produced in the area of an external stimulus; osteodentin
Dentin is formed by cells called odontoblasts.
These cells derive from the ectomesenchyme and produce the organic matrix that will calcify and become the dentin.
Formation of dentin initiates formation of enamel.
The formation of dentin starts during late bell-stage in the area of the future cusp.
First coronal dentin and then root dentin.
Completion of dentin does not occur until about 18 months after eruption of primary and 2-3 years after eruption of permanent teeth.
The rate of dentin development varies.
The role of the internal (inner) dental (enamel) epithelium
Cuboidal - Columnar (reverse polarization)
Ectomesenchymal cells of the dental papilla become preodontoblasts - odontoblasts
Acellular zone disappears
Histologic features of dentin
Odontoblasts
Dentinal tubules
Extend through the entire thickness of dentin
S-shaped (primary curvatures) path in the crown, less S-shaped in the root, almost straight in the cervical aspect
Secondary curvatures
Tubular microbranches
Presence of fluid
Intratubular dentin
Dentin in the tubule that is hypermineralized
The term peritubular dentin should not be used
Sclerotic dentin
Dentinal tubules that are occluded with calcified material
Most likely a physiologic response
Reduction of permeability of dentin
Intertubular dentin
Dentin between the tubules
Interglobular dentin
Areas of unmineralized or hypomineralized dentin
The defect affects mineralization and not the architecture of dentin
Incremental lines
Lines of von Ebner: lines associated with 5-day rythmic pattern of dentin deposition
Contour lines of Owen: Originally described by Owen they result from a coincidence of the secondary curvatures between neighboring dentinal tubules.
Granular Layer of Tomes
Seen only in ground sections in the root area covered by cementum
Originally, they were thought to be areas of hypomineralization
They are true spaces obtained by sections going through the looped terminal portions dentinal tubules
DE junction :Scalloped area
Enamel tissue with incremental lines of Retzius and dentin tissue with parallel, curved dentinal tubules are in contact at the irregular dentino-enamel junction. The junction often has a scalloped-shaped morphology
DC junction Dentin Cemental Junction
The Eye and Orbit
AnatomyThe Eye and Orbit
The orbit (eye socket) appears as a bony recess in the skull when it is viewed from anteriorly.
It almost surrounds the eye and their associated muscles, nerves and vessels, together with the lacrimal apparatus.
The orbit is shaped somewhat like a four-side pyramid lying on its side, with its apex pointing posteriorly and its base anteriorly.
Classification of Cementum
Dental Anatomy
Classification of Cementum
Embryologically
Primary and secondary
2. According to cellular component
Acellular: Thin, Amorphous, First layer to seal the dentin tubules
Cellular: Thick, Better structure, Apical surface
Layers of cellular and acellular cementum alternate (randomly)
3. Based on the origin of the collagenous matrix
Extrinsic
Intrinsic
Mixed
4. Combined classification
a. Primary acellular intinsic fiber cementum
b. Primary acellualar extrinsic fiber cementum
c. Secondary cellular intrinsic fiber cementum
d. Secondary cellular mixed fiber cementum
e. Acellular afibrillar cementum
5. Depending on the location and patterning
Intermediate and mixed stratified cementum
Participating Cells
Cementoblasts
Active
Cells are round, plump with basophilic cytoplasm (rough endoplasmic reticulum)
Inactive
Cells have little cytoplasm
Cementocytes
Cementocyte lacuna
cementocyte canaliculus
Cells have fewer organelles compared to cementoblasts. They are found in lacunae and have numerous processes toward the periodontal ligament. Eventually they die due to avascularity
Cementicles
a) free
b) attached
c) embedded
Respiratory Viral Diseases
General Pathology
Respiratory Viral Diseases
Respiratory viral infections cause acute local and systemic illnesses. The common cold, influenza, pharyngitis, laryngitis (including croup), and tracheobronchitis are common.
An acute, usually afebrile, viral infection of the respiratory tract, with inflammation in any or all airways, including the nose, paranasal sinuses, throat, larynx, and sometimes the trachea and bronchi.
Etiology and Epidemiology
Picornaviruses, especially rhinoviruses and certain echoviruses and coxsackieviruses, cause the common cold. About 30 to 50% of all colds are caused by one of the > 100 serotypes of rhinoviruses.
Symptoms and Signs
Clinical symptoms and signs are nonspecific.
After an incubation period of 24 to 72 h, onset is abrupt, with a burning sensation in the nose or throat, followed by sneezing, rhinorrhea, and malaise.
Characteristically, fever is not present, particularly with a rhinovirus or coronavirus. Pharyngitis usually develops early; laryngitis and tracheobronchitis vary by person and causative agent. Nasal secretions are watery and profuse during the first days, but become more mucoid and purulent.
Cough is usually mild but often lasts into the 2nd wk.
Methyl salicylate
Pharmacology
Methyl salicylate
also known as oil of wintergreen, betula oil, methyl ester) is a natural product of many species of plants Structurally, it is methylated salicylic acid It is used as an ingredient in deep heating rubs
Guardsman Fracture
Oral and Maxillofacial SurgeryGuardsman Fracture (Parade Ground Fracture)
Definition: The Guardsman fracture, also known as the parade
ground fracture, is characterized by a combination of symphyseal and bilateral
condylar fractures of the mandible. This type of fracture is often associated
with specific mechanisms of injury, such as direct trauma or falls.
Fracture Components:
Symphyseal Fracture: Involves the midline of the
mandible where the two halves meet.
Bilateral Condylar Fractures: Involves fractures of
both condyles, which are the rounded ends of the mandible that
articulate with the temporal bone of the skull.
Mechanism of Injury:
Guardsman fractures typically occur due to significant trauma, such
as a fall or blunt force impact, which can lead to simultaneous
fractures in these areas.
Clinical Implications:
Inadequate Fixation: If the fixation of the
symphyseal fracture is inadequate, it can lead to complications such as:
Splaying of the Cortex: The fracture fragments
may open on the lingual side, leading to a widening of the fracture
site.
Increased Interangular Distance: The splaying
effect increases the distance between the angles of the mandible,
which can affect occlusion and jaw function.
Symptoms:
Patients may present with pain, swelling, malocclusion, and
difficulty in jaw movement. There may also be visible deformity or
asymmetry in the jaw.
Management:
Surgical Intervention: Proper fixation of both the
symphyseal and condylar fractures is crucial. This may involve the use
of plates and screws to stabilize the fractures and restore normal
anatomy.
Periodontium
Dental Anatomy
The periodontium, which is the supporting structure of a tooth, consists of the cementum, periodontal ligaments, gingiva, and alveolar bone. Cementum is the only one of these that is a part of a tooth. Alveolar bone surrounds the roots of teeth to provide support and creates what is commonly called a "socket". Periodontal ligaments connect the alveolar bone to the cementum, and the gingiva is the surrounding tissue visible in the mouth.
Periodontal ligaments
Histology of the Periodontal Ligament (PDL)
Embryogenesis of the periodontal ligament
The PDL forms from the dental follicle shortly after root development begins
The periodontal ligament is characterized by connective tissue. The thinnest portion is at the middle third of the root. Its width decreases with age. It is a tissue with a high turnover rate.
Hypothalamic - Pituitary Drugs
Pharmacology
Hypothalamic - Pituitary Drugs
Somatropin
Growth hormone (GH) mimetic
Mechanism
agonist at GH receptors
increases production of insulin growth factor-1 (IGF-1)
Clinical use
GH deficiency
increase adult height for children with conditions associated with short stature
Turner syndrome
wasting in HIV infection
short bowel syndrome
Toxicity
scoliosis
edema
gynecomastia
increased CYP450 activity
Octreotide
Somatostatin mimetic
Mechanism
agonist at somatostatin receptors
Clinical use
acromegaly
carcinoid
gastrinoma
glucagonoma
acute esophageal variceal bleed
Toxicity
GI upset
gallstones
bradycardia
Oxytocin
Mechanism
agonist at oxytocin receptor
Clinical use
stimulation of labor
uterine contractions
control of uterine hemorrhage after delivery
stimulate milk letdown
Toxicity
fetal distress
abruptio placentae
uterine rupture
Desmopressin
ADH (vasopressin) mimetic
Mechanism
agonist at vasopressin V2 receptors
Clinical use
central (pituitary) diabetes insipidus
hemophilia A (factor VIII deficiency)
increases availability of factor VIII
von Willebrand disease
increases release of von Willebrand factor from endothelial cells
Toxicity
GI upset
headache
hyponatremia
allergic reaction