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NEET MDS Synopsis - Lecture Notes

📚 NEET MDS Lecture Notes

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Pharmacology

Pharmacology

Pharmacology is the study of drugs and the way they interact with living systems.  Clinical pharmacology is the study of drugs in humans.

A drug is any chemical that can effect living processes.

Therapeutics: the medical use of drugs.

An ideal drug has several important properties.  Three of these properties are of utmost importance: effectiveness, safety and selectivity. 

Effectiveness: This is the most important quality that a drug can have.  Effectiveness refers to the drug's ability to do what it is supposed to do.

Safety:  Although no drug can be totally safe, proper usage can lessen the risks of adverse effects.

Selectivity:  A truly selective drug would have no side effects, and would effect only the body process' for which it is designed and given.  Therefore, there is no such thing as a selective drug.

Pharmacokinetics: The way the body deals with a drug.  Pharmacokinetics is concerned with the processes of absorption, distribution, metabolism and excretion.

Pharmacodynamics:  What a drug does to the body.

Pharmacokinetics and pharmacodynamics are two of the processes that determine how a person will respond to a drug.  Other factors include how a drug is administered (dose, route, and timing of administration), interactions with other drugs, and individual physiological variables (weight, age, function of body systems).

CHEMICAL AGENTS

General Microbiology

CHEMICAL AGENTS

Chlorine and iodine are most useful disinfectant Iodine as a skin disinfectant and chlorine as a water disinfectant have given consistently magnificent results. Their activity is almost exclusively bactericidal and they are effective against sporulating organisms also. 
Mixtures of various surface acting agents with iodine are known as iodophores and these are used for the sterilization of dairy products.

Apart from chlorine, hypochlorite, inorganic chioramines are all good disinfectants but they act by liberating chlorine. 

Hydrogen peroxide in a 3% solution is a harmless but very weak disinfectant whose primary use is in the cleansing of the wound.
 
Potassium permanganate is another oxidising agent which is used in the treatment of urethntzs. 

Formaldehyde — is one of the least selective agent acting on proteins. It is a gas that is usually employed as its 37% solution, formalin. 

When used in sufficiently high concentration it destroys the bacteria and their spores.


Classification of chemical sterilizing agents

Chemical disinfectant

Interfere with membrane functions

•    Surface acting agents : Quaternary ammonium, Compounds, Soaps and fatty acids

•    Phenols : Phenol, cresol, Hexylresorcinol

•    Organic solvent : Chloroform, Alcohol

Denatures proteins

•    Acids and alkalies : Organic acids, Hydrochloric acid , Sulphuric acid

Destroy functional groups of proteins

•    Heavy metals :  Copper, silver , Mercury

•    Oxidizing agents: Iodine, chlorine, Hydrogen peroxide

•    Dyes : Acridine orange, Acriflavine

•    Alkylating agents : Formaldehyde, Ethylene oxide

Applications and in-use dilution of chemical disinfectants

Alcohols : Skin antiseptic Surface disinfectant, Dilution used 70%

Mercurials : Skin antiseptic Surface disinfectant Dilution Used 0.1 %

Silver nitrate : Antiseptic (eyes and burns)  Dilution Used 1 %

Phenolic compound : Antiseptic skin washes  Dilution Used .5 -5 %

Iodine : Disinfects inanimate object, Skin antiseptic Dilution used  2%

Chlorine compounds  : Water treatment Disinfect inanimate objects , Dillution used 5 %

Quaternary ammonium Compounds : Skin antiseptic , Disinfects inanimate object, Dilution Used < 1 %

Glutaraldehyde: Heat sensitve instruments, Dilution used 1-2 %

Cold sterilization can be achieved by dipping the precleaned instrument in 2% solution of gluteraldehyde for 15-20 minutes. This time is sufficient to kill the vegetative form as well as spores ofthe organisms that are commonly encountered in the dentistry.

Ethylene oxide is an a agent extensively used in gaseous sterilization. It is active against all kinds of bacteria and their spores. but its greatest utility is in sterilizing those objects which are damaged by heat (e.g. heart lung machine). It is also used to sterlise fragile, heat sensitive equipment, powders as well as components of space crafts.


Evaluation of Disinfectants

Two methods which are widely employed are:

 Phenol coefficient test, Kelsey -Sykes test
 
These tests determine the capacity of disinfectant as well as their ability to retain their activity.
 

Angle’s Classification of Malocclusion
Orthodontics

Angle’s Classification of Malocclusion

Malocclusion refers to the misalignment or incorrect relationship between the teeth of the two dental arches when they come into contact as the jaws close. Understanding occlusion is essential for diagnosing and treating orthodontic issues.

Definitions

  • Occlusion: The contact between the teeth in the mandibular arch and those in the maxillary arch during functional relations (Wheeler’s definition).
  • Malocclusion: A condition characterized by a deflection from the normal relation of the teeth to other teeth in the same arch and/or to teeth in the opposing arch (Gardiner, White & Leighton).

Importance of Classification

Classifying malocclusion serves several purposes:

  • Grouping of Orthodontic Problems: Helps in identifying and categorizing various orthodontic issues.
  • Location of Problems: Aids in pinpointing specific areas that require treatment.
  • Diagnosis and Treatment Planning: Facilitates the development of effective treatment strategies.
  • Self-Communication: Provides a standardized language for orthodontists to discuss cases.
  • Documentation: Useful for recording and tracking orthodontic problems.
  • Epidemiological Studies: Assists in research and studies related to malocclusion prevalence.
  • Assessment of Treatment Effects: Evaluates the effectiveness of orthodontic appliances.

Normal Occlusion

Molar Relationship

According to Angle, normal occlusion is defined by the relationship of the mesiobuccal cusp of the maxillary first molar aligning with the buccal groove of the mandibular first molar.

Angle’s Classification of Malocclusion

Edward Angle, known as the father of modern orthodontics, first published his classification in 1899. The classification is based on the relationship of the mesiobuccal cusp of the maxillary first molar to the buccal groove of the mandibular first molar. It is divided into three classes:

Class I Malocclusion (Neutrocclusion)

  • Definition: Normal molar relationship is present, but there may be crowding, misalignment, rotations, cross-bites, and other irregularities.
  • Characteristics:
    • Molar relationship is normal.
    • Teeth may be crowded or rotated.
    • Other alignment irregularities may be present.

Class II Malocclusion (Distocclusion)

  • Definition: The lower molar is positioned distal to the upper molar.
  • Characteristics:
    • Often results in a retrognathic facial profile.
    • Increased overjet and overbite.
    • The mesiobuccal cusp of the maxillary first molar occludes anterior to the buccal groove of the mandibular first molar.

Subdivisions of Class II Malocclusion:

  1. Class II Division 1:
    • Class II molars with normally inclined or proclined maxillary central incisors.
  2. Class II Division 2:
    • Class II molars with retroclined maxillary central incisors.

Class III Malocclusion (Mesiocclusion)

  • Definition: The lower molar is positioned mesial to the upper molar.
  • Characteristics:
    • Often results in a prognathic facial profile.
    • Anterior crossbite and negative overjet (underbite).
    • The mesiobuccal cusp of the upper first molar falls posterior to the buccal groove of the lower first molar.

Advantages of Angle’s Classification

  • Comprehensive: It is the first comprehensive classification and is widely accepted in the field of orthodontics.
  • Simplicity: The classification is straightforward and easy to use.
  • Popularity: It is the most popular classification system among orthodontists.
  • Effective Communication: Facilitates clear communication regarding malocclusion.

Disadvantages of Angle’s Classification

  • Limited Plane Consideration: It primarily considers malocclusion in the anteroposterior plane, neglecting transverse and vertical dimensions.
  • Fixed Reference Point: The first molar is considered a fixed point, which may not be applicable in all cases.
  • Not Applicable for Deciduous Dentition: The classification does not effectively address malocclusion in children with primary teeth.
  • Lack of Distinction: It does not differentiate between skeletal and dental malocclusion.
ORMOCER (Organically Modified Ceramic)
Conservative Dentistry

ORMOCER (Organically Modified Ceramic)

ORMOCER is a modern dental material that combines organic and inorganic components to create a versatile and effective restorative option. Introduced as a dental restorative material in 1998, ORMOCER has gained attention for its unique properties and applications in dentistry.

1. Composition of ORMOCER

ORMOCER is characterized by a complex structure that includes both organic and inorganic networks. The main components of ORMOCER are:

A. Organic Molecule Segments

  • Methacrylate Groups: These segments form a highly cross-linked matrix, contributing to the material's strength and stability.

B. Inorganic Condensing Molecules

  • Three-Dimensional Networks: The inorganic components are formed through inorganic polycondensation, creating a robust backbone for the ORMOCER molecules. This structure enhances the material's mechanical properties.

C. Fillers

  • Additional Fillers: Fillers are incorporated into the ORMOCER matrix to improve its physical properties, such as strength and wear resistance.

2. Properties of ORMOCER

ORMOCER exhibits several advantageous properties that make it suitable for various dental applications:

  1. Biocompatibility: ORMOCER is more biocompatible than conventional composites, making it a safer choice for dental restorations.

  2. Higher Bond Strength: The material demonstrates superior bond strength, enhancing its adhesion to tooth structure and restorative materials.

  3. Minimal Polymerization Shrinkage: ORMOCER has the least polymerization shrinkage among resin-based filling materials, reducing the risk of gaps and microleakage.

  4. Aesthetic Qualities: The material is highly aesthetic and can be matched to the natural color of teeth, making it suitable for cosmetic applications.

  5. Mechanical Strength: ORMOCER exhibits high compressive strength (410 MPa) and transverse strength (143 MPa), providing durability and resistance to fracture.

3. Indications for Use

ORMOCER is indicated for a variety of dental applications, including:

  1. Restorations for All Types of Preparations: ORMOCER can be used for direct and indirect restorations in various cavity preparations.

  2. Aesthetic Veneers: The material's aesthetic properties make it an excellent choice for fabricating veneers that blend seamlessly with natural teeth.

  3. Orthodontic Bonding Adhesive: ORMOCER can be utilized as an adhesive for bonding orthodontic brackets and appliances to teeth.