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NEET MDS Synopsis

Classification of Fatty Acids and Triglycerides
Biochemistry

Classification of Fatty Acids and Triglycerides

 

Short-chain: 2-4 carbon atoms

Medium-chain: 6-12 carbon atoms

Long-chain: 14-20 carbon atoms

Very long-chain: >20 carbon atoms

 

• are usually in esterified form as major components of other lipids

 

 

A16-carbon fatty acid, with one cis double bond between carbon atoms 9 and 10 may be represented as 16:1 cisD9.



 

Double bonds in fatty acids usually have the cis configuration. Most naturally occurring fatty acids have an even number of carbon atoms

 

Examples of fatty acids





18:0


stearic acid




18:1 cisD9    


oleic acid




18:2 cisD9,12


linoleic acid




18:3 cisD9,12,15  


linonenic acid 




20:4 cisD5,8,11,14   


arachidonic acid





 

 

There is free rotation about C-C bonds in the fatty acid hydrocarbon, except where there is a double bond. Each cis double bond causes a kink in the chain,

Hypoxia
Physiology

Hypoxia


Hypoxia is tissue oxygen deficiency
Brain is the most sensitive tissue to hypoxia: complete lack of oxygen can cause unconsciousness in 15 sec and irreversible damage within 2 min.
Oxygen delivery and use can be interrupted at several sites


 





Type of
Hypoxia


O2 Uptake
in Lungs


Hemoglobin


Circulation


 Tissue O2 Utilization




 Hypoxic


 Low


Normal


Normal


Normal




 Anemic


 Normal


 Low


Normal


Normal




 Ischemic


 Normal


Normal


 Low


Normal




 Histotoxic


 Normal


Normal


Normal


 Low






Causes:

Hypoxic: high altitude, pulmonary edema, hypoventilation, emphysema, collapsed lung
Anemic: iron deficiency, hemoglobin mutations, carbon monoxide poisoning
Ischemic: shock, heart failure, embolism
Histotoxic: cyanide poisoning (inhibits mitochondria)




 


Carbon monoxide (CO) poisoning:


CO binds to the same heme Fe atoms that O2 binds to
CO displaces oxygen from hemoglobin because it has a 200X greater affinity for hemoglobin.
Treatment for CO poisoning: move victim to fresh air. Breathing pure O2 can give faster removal of CO




 


Cyanide poisoning:


Cyanide inhibits the cytochrome oxidase enzyme of mitochondria
Two step treatment for cyanide poisoning:

1) Give nitrites

Nitrites convert some hemoglobin to methemoglobin. Methemoglobin pulls cyanide away from mitochondria.


2) Give thiosulfate.

Thiosulfate converts the cyanide to less poisonous thiocyanate.







Serotonin or 5-hydroxytryptamine
Pharmacology

Serotonin or 5-hydroxytryptamine (5-HT)

It is a neurotransmitter, widely distributed in the CNS, beginning in the midbrain and projecting into thalamus, hypothalamus, cerebral cortex, and spinal cord. CNS serotonin is usually an inhibitory neurotransmitter and is associated with mood, the sleep-wake cycle.

Serotonin is thought to produce sleep by inhibiting CNS activity. 

In the blood, 5-HT is present in high concentration in platelets (regulator of platelets function) and also high concentration in intestine

Pharmacological effects:

Smooth muscles. 5-HT stimulates the G.I smooth muscle; it increases the peristaltic movement of intestine.
Serotonin contracts the smooth muscle of bronchi; 

Blood vessels. If serotonin is injected i.v, the blood pressure usually first rises, because of the contraction of large vessels and then falls because of arteriolar dilatation. Serotonin causes aggregation of platelets. 

Specific agonists

- Sumatriptan a selective 5-HT1D used in treatment of acute migraine.
- Buspirone a selective 5-HT1A used in anxiety.
- Ergotamine is a partial agonist used in migraine. It acts on 5-HT1A receptor.

Nonspecific 5-HT receptor agonist

o Dexfenfluramine used as appetite suppressant.

Specific antagonists

o Spiperone (acts on 1A receptor) and
o Methiothepin (acts on 1A, 1B, 1D receptors)

Anemia (Disorder of Hematopoietic System)
General Pathology

Anemia (Disorder of Hematopoietic System) - Probably the most common effect of nutritional deficiency. Any factor that decreases hematopoiesis can cause an anemia.

A. Iron deficiency - Widely recognized as the most important cause of anemia, It is indicated that ½ of all pregnant women and infants are affected, as are ~13% of all adult women.

1. Dietary factors - Availability of iron from different food sources and mixtures.
2. Malabsorption – One third of patients with inflammatory bowel disease (IBD) have recurrent anemia and 30% or more of patients who have had partial gastrectomy will develop iron deficiency anemia.
3. Blood loss - Menses, gastrointestinal bleeding 
4. Increased demand - Pregnancy, growth in children.
5. Congenital - Atransferrinemia
6. Importance of multiple factors.
7. Pathophysiology - Initially iron is mobilized from reticuloendothelial stores and increased intestinal absorption occurs. Total iron stores are depleted, serum iron levels fall. In severe cases in peripheral blood, the red cells become smaller (microcytic) and their hemoglobin content is reduced (hypochromic).  


B. Megaloblastic anemias- Characterized by the presence of abnormal WBCs and RBCs. In severe cases, megaloblasts (abnormal red cell precursors) may be present. These anemias are a consequence of disordered DNA synthesis.
1. Folate deficiency - Can be caused by:
a. Dietary deficiency
b. Malabsorption (celiac disease)
c. Increased demand (pregnancy & lactation)
d. Drugs - methotrexate, anticonvulsants, oral contraceptives, alcoholism.
e. Liver disease

2. Cobalamin (vitamin B12) deficiency - Almost always a secondary disorder that can  be caused by:

a. Intrinsic factor deficiency (pernicious anemia due to autoimmune destruction of the gastric mucosa)

b. Malabsorption

3. Pyridoxine (vitamin B6) deficiency- most commonly associated with alcoholism.

C. Other factors known to be frequently associated with anemia would include protein-calorie malnutrition, vitamin C deficiency, and pyridoxine deficiency (usually associated with alcoholism).

D. Other anemias not particularly associated with nutritional disease would include hemolytic anemia
(decreased red cell life span) and aplastic anemia (failure of marrow to produce new cells).  

Walsham’s Forceps
General Surgery

Walsham’s Forceps
Walsham’s forceps are specialized surgical instruments used
primarily in the manipulation and reduction of fractured nasal fragments. They
are particularly useful in the management of nasal fractures, allowing for
precise adjustment and stabilization of the bone fragments during the reduction
process.


Design:

Curved Blades: Walsham’s forceps feature two curved
blades—one padded and one unpadded. The curvature of the blades allows
for better access and manipulation of the nasal structures.
Padded Blade: The padded blade is designed to
provide a gentle grip on the external surface of the nasal bone and
surrounding tissues, minimizing trauma during manipulation.
Unpadded Blade: The unpadded blade is inserted into
the nostril and is used to secure the internal aspect of the nasal bone
and associated fragments.



Usage:

Insertion: The unpadded blade is carefully passed
up the nostril to reach the fractured nasal bone and the associated
fragment of the frontal process of the maxilla.
Securing Fragments: Once in position, the nasal
bone and the associated fragment are secured between the padded blade
externally and the unpadded blade internally.
Manipulation: The surgeon can then manipulate the
fragments into their correct anatomical position, ensuring proper
alignment and stabilization.



Indications:

Walsham’s forceps are indicated for use in cases of nasal fractures,
particularly when there is displacement of the nasal bones or associated
structures. They are commonly used in both emergency and elective
settings for nasal fracture management.



Advantages:

Precision: The design of the forceps allows for
precise manipulation of the nasal fragments, which is crucial for
achieving optimal alignment and aesthetic outcomes.
Minimized Trauma: The padded blade helps to reduce
trauma to the surrounding soft tissues, which can be a concern during
the reduction of nasal fractures.



Postoperative Considerations:

After manipulation and reduction of the nasal fragments, appropriate
postoperative care is essential to monitor for complications such as
swelling, infection, or malunion. Follow-up appointments may be
necessary to assess healing and ensure that the nasal structure remains
stable.



The Auditory Ossicles
Anatomy

The Auditory Ossicles

The Malleus


Its superior part, the head, lies in the epitympanic recess.
The head articulates with the incus.



The neck, lies against the flaccid part of the tympanic membrane.
The chorda tympani nerve crosses the medial surface of the neck of the malleus.



The handle of the malleus (L. hammer) is embedded in the tympanic membrane and moves with it.
The tendon of the tensor tympani muscle inserts into the handle.


The Incus


Its large body lies in the epitympanic recess where it articulates with the head of the malleus.
The long process of the incus (L. an anvil) articulates with the stapes.
The short process is connected by a ligament to the posterior wall of the tympanic cavity.


The Stapes


The base (footplate) of the stapes (L. a stirrup), the smallest ossicle, fits into the fenestra vestibuli or oval window on the medial wall of the tympanic cavity.


Functions of the Auditory Ossicles


The auditory ossicles increase the force but decrease the amplitude of the vibrations transmitted from the tympanic membrane.




Spray Particles
Conservative Dentistry

Spray Particles in the Dental Operatory
1. Aerosols
Aerosols are composed of invisible particles that range in size from
approximately 5 micrometers (µm) to 50 micrometers (µm).
Characteristics

Suspension: Aerosols can remain suspended in the air
for extended periods, often for hours, depending on environmental
conditions.
Transmission of Infection: Because aerosols can carry
infectious agents, they pose a risk for the transmission of respiratory
infections, including those caused by bacteria and viruses.

Clinical Implications

Infection Control: Dental professionals must implement
appropriate infection control measures, such as the use of personal
protective equipment (PPE) and effective ventilation systems, to minimize
exposure to aerosols.

2. Mists

Mists are visible droplets that are larger than aerosols, typically estimated to
be around 50 micrometers (µm) in diameter.
Characteristics

Visibility: Mists can be seen in a beam of light,
making them distinguishable from aerosols.
Settling Time: Heavy mists tend to settle gradually
from the air within 5 to 15 minutes after being generated.

Clinical Implications

Infection Risk: Mists produced by patients with
respiratory infections, such as tuberculosis, can transmit pathogens. Dental
personnel should be cautious and use appropriate protective measures when
treating patients with known respiratory conditions.

3. Spatter

Spatter consists of larger particles, generally greater than 50 micrometers
(µm), and includes visible splashes.
Characteristics

Trajectory: Spatter has a distinct trajectory and
typically falls within 3 feet of the patient’s mouth.
Potential for Coating: Spatter can coat the face and
outer garments of dental personnel, increasing the risk of exposure to
infectious agents.

Clinical Implications

Infection Pathways: Spatter or splashing onto mucosal
surfaces is considered a potential route of infection for dental personnel,
particularly concerning blood-borne pathogens.
Protective Measures: The use of face shields, masks,
and protective clothing is essential to minimize the risk of exposure to
spatter during dental procedures.

4. Droplets

Droplets are larger than aerosols and mists, typically ranging from 5 to 100
micrometers in diameter. They are formed during procedures that involve the use
of water or saliva, such as ultrasonic scaling or high-speed handpieces.
Characteristics

Size and Behavior: Droplets can be visible and may
settle quickly due to their larger size. They can travel short distances but
are less likely to remain suspended in the air compared to aerosols.
Transmission of Pathogens: Droplets can carry
pathogens, particularly during procedures that generate saliva or blood.

Clinical Implications

Infection Control: Droplets can pose a risk for
respiratory infections, especially in procedures involving patients with
known infections. Proper PPE, including masks and face shields, is essential
to minimize exposure.

5. Dust Particles
Dust particles are tiny solid particles that can be generated from various
sources, including the wear of dental materials, the use of rotary instruments,
and the handling of dental products.
Characteristics

Size: Dust particles can vary in size but are generally
smaller than 10 micrometers in diameter.
Sources: They can originate from dental materials, such
as composite resins, ceramics, and metals, as well as from the environment.

Clinical Implications

Respiratory Risks: Inhalation of dust particles can
pose respiratory risks to dental personnel. Effective ventilation and the
use of masks can help reduce exposure.
Allergic Reactions: Some individuals may have allergic
reactions to specific dust particles, particularly those derived from dental
materials.

6. Bioaerosols
Bioaerosols are airborne particles that contain living organisms or
biological materials, including bacteria, viruses, fungi, and allergens.
Characteristics

Composition: Bioaerosols can include a mixture of
aerosols, droplets, and dust particles that carry viable microorganisms.
Sources: They can be generated during dental
procedures, particularly those that involve the manipulation of saliva,
blood, or infected tissues.

Clinical Implications

Infection Control: Bioaerosols pose a significant risk
for the transmission of infectious diseases. Implementing strict infection
control protocols, including the use of high-efficiency particulate air
(HEPA) filters and proper PPE, is crucial.
Monitoring Air Quality: Regular monitoring of air
quality in the dental operatory can help assess the presence of bioaerosols
and inform infection control practices.

7. Particulate Matter (PM)
Particulate matter (PM) refers to a mixture of solid particles and liquid
droplets suspended in the air. In the dental context, it can include a variety
of particles generated during procedures.
Characteristics

Size Categories: PM is often categorized by size,
including PM10 (particles with a diameter of 10 micrometers or less) and
PM2.5 (particles with a diameter of 2.5 micrometers or less).
Sources: In a dental setting, PM can originate from
dental materials, equipment wear, and environmental sources.

Clinical Implications

Health Risks: Exposure to particulate matter can have
adverse health effects, particularly for individuals with respiratory
conditions. Proper ventilation and air filtration systems can help mitigate
these risks.
Regulatory Standards: Dental practices may need to
adhere to local regulations regarding air quality and particulate matter
levels.

Stylohyoid Muscle
Anatomy

Stylohyoid Muscle

Origin: Posterior border of the styloid process of the
temporal bone.
Insertion: Body of the hyoid bone at the junction with
the greater horn.
Nerve Supply: Facial nerve (CN VII).
Arterial Supply: Muscular branches of the facial artery
and muscular branches of the occipital artery.
Action: Elevates the hyoid bone and base of the tongue.

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