NEET MDS Synopsis
Gypsum Products
Dental Materials
Gypsum Products
Characteristics
Plaster
Stone
Diestone
Chemical Name
Beta-Calcium Sulfate hemihydrate
Alpha-Calcium sulfate hemihydrate
Alpha-Calcium sulfate hemihydrate
Formula
CaSO4 – ½ H2O
CaSO4 – ½ H2O
CaSO4 – ½ H2O
Uses
Plaster Models ,Impression Plasters
Cast Stone, Investment
Improved Stone, diestone
Water(W)
Reaction Water
Extra Water
Total water
Powder (P)
W/P Ratio
18ml
32ml
50ml
100g
0.50
18ml
12ml
30ml
100g
0.30
18ml
6ml
24ml
100g
0.24
Different Systems of the CNS & their functions
Pharmacology
Different Systems of the CNS & their functions
These systems are pathways formed of specific parts of the brain and the neurons connecting them.
They include:
1.The pyramidal system
2.The extrapyramidal system
3.The limbic system
4.The reticular formation
5.The tuberohypophyseal system
The pyramidal system:
It originates from the motor area of the cerebral cortex and passes through the spinal cord, therefore it is also known as the “corticospinaltract”.
It is responsible for the regulation of the fine voluntary movements.
The extrapyramidal system:
It also controls the motor functionbut involves areas other than the corticospinal tract.
It is involved in the regulation of gross voluntary movements, thus it complements the function of the pyramidal system.
The “basal ganglia” constitute an essential part of this system.
Degenerative changes in the pathway running from the “substantianigra”to the “corpus striatum”(or nigrostriatal pathway) may cause tremors and muscle rigidity characteristic of “Parkinson’s disease”.
The limbic system:
The major parts of this system are: the hypothalamus, the basal ganglia, the hippocampus(responsible for short term memory), and some cortical areas.
The limbic system is involved in the control of “behavior”& “emotions”.
The reticular formation:
It is composed of interlacing fibers and nerve cells that run in all directions beginning from the upper part of the spinal cord and extending upwards.
It is important in the control of “consciousness” and “wakefulness”.
The tuberohypophyseal system:
It is a group of short neurons running from the hypothalamusto the hypophysis(pituitary gland) regulating its secretions.
ZINC
Biochemistry
ZINC
The enzyme RNA polymerase, which is required for transcription, contains zinc and it is essential for protein bio synthesis.
Deficiency in Zinc leads to poor wound healing, lesions of skin impaired spermatogenesis, hyperkeratosis, dermatitis and alopecia
MICROBIAL VIRULENCE FACTORS
General Microbiology
MICROBIAL VIRULENCE FACTORS
Microbial virulence factors are gene products required for a microbial pathogen to establish itself in the host. These gene products are located on the bacterial chromosome, or on mobile genetic elements, such as plasmids or transposons.
Primary pathogens express virulence factors that allow them to cause disease in the normal host.
Opportunistic pathogens are environmental organisms or normal flora that lack the means to overcome normal host defense mechanisms. They cause disease only when the normal host defenses are breached or deficient.
Virulence factors can be divided into several categories.
Skin - Propionibacterium acnes, Staphlococcus epidermis , diptheroids; transient colonization by Staphlococcus
aureus
Oral cavity - Viridans Streptococci, Branhamella species, Prevotella melaninogenicus, Actinomyces species, Peptostreptococcus species, other anaerobes
Nasopharynx Oral organisms; transient colonization by S. pneumoniae, Haemophilus species, N. meningitidis
Stomach Rapidly becomes sterile
Small intestine Scant
Colon - Bacteroides species, Clostridium species, Fusobacterium species, E. coli, Proteus species, Pseudomonas aeruginosa, Enterococcus species, other bacteria and yeasts
Vagina - Childbearing years:Lactobacillus species, yeasts, Streptococcus species
Prepuberty / Postmenopause: colonic and skin flora
A. Enzyme production can be of several types depending on the needs of the organism, its requirements for survival, and the local environment.
1. Hyaluronidase breaks down hyaluronic acid to aid in the digestion of tissue.
2. Protease digests proteins to enhance the spread of infections.
3. Coagulase allows coagulation of fibrinogen to clot plasma.
4. Collagenase breaks down collagen (connective tissues).
B. Toxins
1. Exotoxins are heat-labile proteins with specific enzymatic activities produced by many Gram-positive and Gram-negative organisms. Exotoxins are released extracellularly and are often the sole cause of disease.
a. Some toxins have several domains with discrete biological functions that confer maximal toxicity. An example is A-B exotoxin, where the B subunit binds to host tissue cell glycoproteins and the A subunit enzymatically attacks a susceptible target.
b. Many toxins are ADP-ribosylating toxins
2. Endotoxin is the heat-stable lipopolysaccharide moiety found in the outer membrane of Gram-negative organisms. when released by cell lysls, the lipid A portion of lipopolysaccharide can induce septic shock characterized by fever, acidosis, hypotension, complement consumption, and disseminated intravascular coagulation (DIC).
C. Surface components
may protect the organism from immune responses such as phagocytosis or aid in tissue invasion. For example, the polysaccharide capsules of H. influenzae type b and the acidic polysaccharide capsule of Streptococcus pneumoniae interfere with phagocytosis. Other surface proteins, such as adhesins or filamentous appendages (fimbriae, pili), are involved in adherence of invading microorganisms to cells of the host.
MANDIBULAR CUSPIDS
Dental Anatomy
MANDIBULAR CUSPIDS
Mandibular canines are those lower teeth that articulate with the mesial aspect of the upper canine.
Facial: The mandibular canine is noticeably narrower mesidistally than the upper, but the root may be as long as that of the upper canine. In an individual person,the lower canine is often shorter than that of the upper canine. The mandibular canine is wider mesiodistally than either lower incisor. A distinctive feature is the nearly straight outline of the mesial aspect of the crown and root. When the tooth is unworn, the mesial cusp ridge appears as a sort of 'shoulder' on the tooth. The mesial cusp ridge is much shorter than the distal cusp ridge.
Lingual: The marginal ridges and cingulum are less prominent than those of the maxillary canine. The lingual surface is smooth and regular. The lingual ridge, if present, is usually rather subtle in its expression.
Proximal: The mesial and distal aspects present a triangular outline. The cingulum as noted is less well developed. When the crown and root are viewed from the proximal, this tooth uniquely presents a crescent-like profile similar to a cashew nut.
Incisal: The mesiodistal dimension is clearly less than the labiolingual dimension. The mesial and distal 'halves' of the tooth are more identical than the upper canine from this perspective. In the mandibular canine, the unworn incisal edge is on the line through the long axis of this tooth.
Cells Of The Exudate
General Pathology
Cells Of The Exudate
Granulocytes (Neutrophils, eosinophils, and basophils)
Monocytes (and tissue macrophages)
Lymphocytes
Neutrophils (polymorphs).
Characteristics
(1) Cell of acute inflammation.
(2) Actively motile.
(3) Phagocytic.
(4) Respond to chemotactic agents like.
Complement products.
Bacterial products.
Tissue breakdown
Lysosomal enzymes of other polymorphs
Functions
(1) Phagocytosis and intracellular digestion of bacteria.
(2) Exocytosis of lysosomal enzymes to digest dead tissue as the first step in the process of repair.
Eosinophils
Characteristics
(I) Cell of allergjc and immunologic inflammation.
(2) Motile and phagocytic but less so than a neutrophil.
(3) Response to chemotaxis similar to neutrophil. In addition, it is also responsive to antigens and antigen-antibody complexes.
(4) Steroids cause depletion of eosinophils.
Functions
(1) Contain most of the lysosomal enzymes that polymorphs have
(2) control of Histamine release and degradation in inflammation
Basophils (and mast cells)
Characteristics
(1) Contain coarse metachromatic granules.
(2) Contain, histamine and proteolytic enzymes
Functions
Histamine: release which causes some of the changes of inflammation and allergic
reactions. .
Monocytes .
Blood monocytes form a component of. the mononuclear phagocytic system (MPS), the other being tissue macrophages The tissue macrophages may be :
(a) Fixed phagocytic. cells:
Kuffer cell of liver.
Sinusoidal lining cells of spleen and lymph nodes.
Pleural and peritoneal macrophages
Alveolar macrophages.
Microglial cells.
(b) Wandering macrophages or tissue histiocytes.
The tissue histiocytes are derived from blood monocytes.
Characteristics
.(1)Seen in inflammation of some duration, as they -outlive polymorphs.
(2) Actively phagocytic and motile.
(3) Fuse readily to from giant cells in certain situations.
Function
(1) Phagocytosis.
(2) Lysosomal enzyme secretion.
(3) Site of synthesis of some components of complement.
(4) Antigen handling and processing before presenting it to the Immune competent cell.
(5) Secretion of lysosyme and interferon.
Giant cells can be
(A) Physiological
Syncytiotrophoblast, megakatyocytes, striated muscle, osteoclast.
(B) Pathological:
Foreign body: in the presence of particulate foreign matter like talc, suture material etc. and in certain infections_e g fungal.
Langhan's type: a variant of foreign body giant cell seen in tuberculosis.
Touton type in lipid rich situations like Xanthomas, lipid granulomas etc.
(iv) Aschoff cell in rheumatic carditis.
(v) Tumour gjant cells e.g. Reid-Sternberg cell in Hodgkin's Lymphoma, giant cells in any malignancy.
Lymphocytes and Plasma cells
These are the small mononuclear cell comprising the immune system
They are less motile than_macrophages and neutrophils and are seen in chronic inflammation and immune based diseases.
The Walls of the Orbit
AnatomyThe Walls of the Orbit
Each orbit has four walls: superior (roof), medial, inferior (floor) and lateral.
The medial walls of the orbit are almost parallel with each other and with the superior part of the nasal cavities separating them.
The lateral walls are approximately at right angles to each other
Maxillary Third Permanent Molar
Dental Anatomy
Maxillary Third Permanent Molar
They are the teeth most often congenitally missing
Facial: The crown is usually shorter in both axial and mesiodistal dimensions. Two buccal roots are present, but in most cases they are fused. The mesial buccal cusp is larger than the distal buccal cusp.
Lingual: In most thirds, there is just one large lingual cusp. In some cases there is a poorly developed distolingual cusp and a lingual groove. The lingual root is often fused to the to buccal cusps.
Proximal: The outline of the crown is rounded; it is often described as bulbous in dental literature. Technically, the mesial surface is the only 'proximal' surface. The distal surface does not contact another tooth.
Occlusal: The crown of this tooth is the smallest of the maxillary molars. The outline of the occlusal surface can be described as heart-shaped. The mesial lingual cusp is the largest, the mesial buccal is second in size, and the distal buccal cusp is the smallest.
Root Surface:-The root may have from one to as many as eight divisions. These divisions are usually fused and very often curved distally.