NEET MDS Synopsis
TEMPOROMANDIBULAR JOINT
Dental Anatomy
TEMPOROMANDIBULAR JOINT
There are three kind of joints:
· Fibrous
Two bones connected with fibrous tissue
Examples
suture (little or no movement)
gomphosis (tooth - PDL - bone)
syndesmosis (fibula & tibia, radius and ulna; interosseous ligament)
· Cartilagenous
Two subtypes:
2a) primary: bone<--->cartilage (costochondral joint)
2b) secondary: bone<-->cartilage<-->FT<-->cartilage<--> bone (pubic symphysis)
· Synovial
Two bones; each articular surface covered with hyaline cartilage in most cases
The bones are united with a capsule (joint cavity)
In the capsule there is presence of synovial fluid
The capsule is lined by a synovial membrane
In many synovial joints there maybe an articular disk
Synovial joints are characterized by the presence of ligaments
Synovial joints are classified according to the number of axes of bone movement: uniaxial, biaxial, multiaxial
the shapes of articulating surfaces: planar, ginglymoid (=hinged), pivot, condyloid
The movement of the joints is controlled by muscles
The temporomandibular joint is a synovial, sliding-ginglymoid joint (humans)
Embryology of the TMJ
Primary TMJ: Meckel's cartilage --> malleus & incal cartilage. It lasts for 4 months.
Secondary TMJ: Starts developing around the third month of gestation
Two blastemas (temporal and condylar); condylar grows toward the temporal (temporal appears and ossifies first)
Formation of two cavities: inferior and upper
Appearance of disk
Bones: glenoid fossa (temporal bone) and condyle (mandible)
Methods of general anesthesia
Pharmacology
Methods of general anesthesia
CIRCLE SYSTEM
*HIGH-FLOW
FRESH GAS FLOW > 3 l/min.
*LOW-FLOW
FGF ok. 1l/min.
*MINIMAL-FLOW
FGF ok. 0,5 l/min.
Drugs Used in Diabetes -Insulin
Pharmacology
Insulin
Insulin is only given parenterally (subcutaneous or IV) Various preparations have different durations of action
Preparation
Onset (hrs)
Peak (hrs)
Duration (hrs)
Lispro (rapid-acting)
15 min
0.5-1.5
3-4
Regular (short-acting)
0.5-1
2-4
5-7
NPH (intermediate)
1-2
6-12
18-24
Glargine (long-acting)
1
None
>24
Mechanism
bind transmembrane insulin receptor
activate tyrosine kinase
phosphorylate specific substrates in each tissue type
liver
↑ glycogenesis
store glucose as glycogen
muscle
↑ glycogen and protein synthesis
↑ K+ uptake
fat
increase triglyceride storage
Clinical use
type I DM
type II DM
life-threatening hyperkalemia
increases intracellular K+
stress-induced hyperglycemia
Toxicity
hypoglycemia
hypersensitivity reaction (very rare)
Insulin Synthesis
first generated as preproinsulin with an A chain and B chain connected by a C peptide.
c-peptide is cleaved from proinsulin after packaging into vesicles leaving behind the A and B chains
Glycogen Storage Diseases
Biochemistry
Glycogen Storage Diseases are genetic enzyme deficiencies associated with excessive glycogen accumulation within cells.
When an enzyme defect affects mainly glycogen storage in liver, a common symptom is hypoglycemia (low blood glucose), relating to impaired mobilization of glucose for release to the blood during fasting.
When the defect is in muscle tissue, weakness and difficulty with exercise result from inability to increase glucose entry into Glycolysis during exercise.
Various type of Glycogen storage disease are
Type
Name
Enzyme Deficient
I
Von Geirke’s Disease
Glucose -6-phosphate
II
Pompe’s Disease
(1, 4)glucosidase
III
Cori’s Disease
Debranching Enzymes
IV
Andersen’s Disease
Branching Enzymes
V
McArdle’s Disease
Muscles Glycogen Phosphorylase
OXYMETAZOLINE
Pharmacology
OXYMETAZOLINE
It is a directly acting sympathomimetic amine used in symptomatic relief in nasal congestion which increases mucosal secretion.
It is used:
- As a nasal decongestant in allergic rhinitis, with or without the addition of antazoline or sodium chromoglycate.
- As an ocular decongestant in allergic conjunctivitis.
Compounds like naphazoline and xylometazoline are relatively selective α2 agonists, which on topical application produce local vasoconstriction.
Relationship Classification
Dental Anatomy
Angle classified these relationships by using the first permanent molars
Normal or neutral occlusion (ideal):
Mesiobuccalgroove of the mandibular first molar align with the mesiobuccal cusp of the max laxy first permanent molar
ClassI malocclusion normal molar relationships with alterations to other characteristics of the occlusion such as versions, crossbites, excessive overjets, or overbites
Class II malocclusion a distal relation of the mesiobuccal groove of the mandibular first permanent molar to the mesiobuccal cusp of the maxillary first permanent molar
Division I: protruded maxillary anterior teeth
Division II: one or more maxillary anterior teeth retruded
Class III malocclusion a mesial relation of the mesiobuccal groove of the mandibular first permanent molar to the mesiobuccal cusp of the maxillary molar
Impression Materials -Classification
Dental Materials
Classification
Rigid impression materials
(1) Plaster
(2) Compound
(3) Zinc oxide-eugenol
Flexible hydrocolloid impression materials
(I) Agar-agar (reversible hydrocolloid)
(2) Alginate (irreversible hydrocolloid)
Flexible, elastomeric, or rubber impression materials
(1) Polysulfide rubber (mercaptan rubber)
(2) Silicone rubber (condensation silicone)
(3) Polyether rubber
(4) Polyvinyl siloxane (addition silicone)
The Optic Nerve
Anatomy
This is the second cranial nerve (CN II) and is the nerve of sight.