MDS PREP
Diabetic insipidus is due to the lack of
1 Insulin
2 Angiotensin.
3 Aldosterone.
4 A.D.H.
Physiology
Answer: 4
Diabetic insipidus is due to the lack of 4. A.D.H. (Antidiuretic hormone).
Explanation:
Diabetic insipidus (DI) is a condition characterized by the production of large
volumes of dilute urine due to the lack of the antidiuretic hormone (ADH) or the
body's inability to respond to it. It is different from diabetes mellitus, which
involves problems with insulin and blood sugar regulation.
1. Insulin: Insulin is a hormone produced by the pancreas that plays a critical
role in regulating blood sugar levels. A deficiency or resistance to insulin
leads to diabetes mellitus, not diabetic insipidus. Diabetes mellitus is
characterized by hyperglycemia (high blood sugar) and increased thirst and urine
production due to the inability of the kidneys to reabsorb glucose properly.
2. Angiotensin: Angiotensin is a hormone system that plays a role in the
regulation of blood pressure and fluid balance. It is involved in the
renin-angiotensin-aldosterone system (RAAS). While it is crucial for maintaining
blood pressure, it is not directly related to the pathophysiology of diabetic
insipidus.
3. Aldosterone: Aldosterone is a mineralocorticoid hormone produced by the
adrenal glands. It helps regulate sodium and potassium levels in the body, which
in turn affects fluid and blood volume. While it is essential for electrolyte
and fluid balance, it does not cause diabetic insipidus when lacking.
4. Antidiuretic hormone (ADH): ADH is a hormone produced by the hypothalamus and
stored in the posterior pituitary gland. It acts on the kidneys to increase
water reabsorption, which leads to the production of concentrated urine. In
diabetic insipidus, there is either a deficiency of ADH or the kidneys fail to
respond to it adequately. This results in the kidneys being unable to reabsorb
enough water, leading to the production of large volumes of dilute urine and
increased thirst.
There are two main types of diabetic insipidus: central and nephrogenic. Central
DI occurs when the pituitary gland does not produce enough ADH, while
nephrogenic DI results from the kidneys' inability to respond to ADH. Both types
lead to an imbalance in water regulation and can cause symptoms such as polyuria
(excessive urine production), polydipsia (excessive thirst), and dehydration if
not managed properly.
To treat diabetic insipidus, the underlying cause must be addressed. If it is
central DI, synthetic ADH (desmopressin) is administered to replace the missing
hormone. If it is nephrogenic DI, the treatment focuses on addressing the
kidney's response to ADH and managing symptoms such as maintaining fluid intake
and sometimes medications to reduce urine output.
The average time required for spermatogenesis in humans is:
1) 30 days
2) 42 days
3) 74 days
4) 120 days
Spermatogenesis, the process of producing mature sperm cells from spermatogonia, takes approximately 74 days in humans. This includes the development of spermatids and their subsequent transformation into spermatozoa.
An increase of the pressure within one of the carotid sinuses would result in an increase in
1) Mean arterial pressure
2) Cardiac output
3) The activity of the pressor center
4) The activity of cardiac vagal fibers
Physiology
Answer: 4
An increase of the pressure within one of the carotid sinuses would result in an increase in The activity of cardiac vagal fibers
What is the significance of the transport maximum for substances like glucose and phosphate?
1) It indicates the maximum amount that can be filtered by the glomerulus
2) It represents the maximum amount that can be actively reabsorbed by the tubules
3) It is the point at which the substance begins to be excreted in the urine
4) It is the point at which the substance becomes toxic to the body
The transport maximum for substances like glucose and phosphate represents the maximum amount that can be actively reabsorbed by the tubules before reaching saturation and being excreted in urine.
What is the function of the middle piece in a sperm cell?
1) It produces the enzymes needed for sperm maturation
2) It contains the mitochondria for energy production
3) It is responsible for the sperm's ability to penetrate the egg
4) It is involved in the process of fertilization
The middle piece of a sperm cell contains mitochondria, which provide the energy needed for sperm motility and movement towards the egg.
What is the primary mechanism by which insulin stimulates glucose uptake in the liver?
1) Induction of glucokinase
2) Increase in glycolysis rate
3) Inhibition of gluconeogenesis
4) Stimulation of glycogenolysis
Answer: 1) Induction of glucokinaseExplanation: Insulin enhances glucose uptake in the liver by inducing the synthesis of glucokinase, an enzyme that converts glucose into glucose-6-phosphate. This "glucose trapping" mechanism keeps intracellular glucose levels low and promotes further glucose entry into the cell.
In the presence of antidiuretic hormone (ADH), which part of the nephron becomes highly permeable to water?
1) Proximal Convoluted Tubule (PCT)
2) Loop of Henle
3) Collecting Duct
4) Afferent Arteriole
In the presence of antidiuretic hormone (ADH), the collecting duct becomes highly permeable to water, allowing for increased water reabsorption and concentrated urine.
What is the role of gastrin in the gastric phase of acid secretion?
1) It is released by the pancreas and stimulates acid secretion in the stomach
2) It is released by the duodenum and inhibits acid secretion
3) It is released by the stomach and stimulates acid secretion in response to food
4) It has no role in gastric acid secretion
Physiology
Answer: 3
Gastrin is released from G cells in the antral mucosa of the stomach in response to the presence of food. It stimulates the parietal cells of the stomach to secrete hydrochloric acid and intrinsic factor, contributing to the gastric phase of acid secretion.