MDS PREP
Chelating agent contraindicated in iron and cadmium poisoning
1) Penicillamine
2) Des ferroxamine
3) EDTA
4) BAL
Pharmacology Answer: 4
Dimercaprol (British antilewisite; BAL)
1. Poisoning by As, Hg, Au, Bi, Ni, Sb: it is administered i.m., 5 mg/kg stat, followed by 2-3 mg/kg every 4 – 8 hours for 2 days, then once or twice a day for 10 days. It is partly oxidized and glucuronide conjugated, but mainly excreted as such in 4 – 6 hours. Earlier the treatment is instituted, the better it is. Because the dimercaprolmetal complex dissociates faster in acidic urine and the released metal can damage the kidney, urine is alkalinized during dimercaprol therapy.
2. As an adjuvant to Cal. Disod. Edentate in lead poisoning.
3. As an adjuvant to penicillamine in Cu poisoning and in Wilson’s disease – 300 mg/day i.m. for 10 days every second month.
It is contraindicated in iron and cadmium poisoning, because the dimercaprol-Fe and dimercaprol-Cd complex is itself toxic.
Chlortetracycline acts by interfering with
1. protein synthesis on bacterial but not mammalian ribosomes
2. cell wall synthesis
3. nucleic acid synthesis
4. protein synthesis on mammalian but not bacterial ribosomes
Pharmacology
Answer: 1
Chlortetracycline acts by interfering with protein synthesis on bacterial but not mammalian ribosomes
Morphine can be used in all the following conditions except:
1) Head injury
2) Asthma
3) Hypothyroidism
4) Diabetes
Pharmacology Answer: 1
Morphine is contraindicated in head injury for the following reasons:
Causes carbondioxide retention – this in turn increases intracranial tension
Therapeutic doses can cause respiratory depression in head injury patients Vomiting, miosis and altered mentation caused by morphine can interfere with assessment of neurological status
Morphine should be avoided in those with bronchial asthma as it can precipitate an attack of asthma. But it is not contraindicated
Tyrosine kinase inhibitors are useful in the management of ?
1) Acute myeloid leukemia
2) Small cell carcinoma of lung
3) Gastrointestinal stromal tumors
4) Neurofibromatosis
Pharmacology Answer: 3
Tyrosine kinase inhibitors are used in the treatment of:
Chronic myeloid leukemia
Acute lymphoblastic leukemia ( philadelphia chromosome positive cases )
Head and neck malignancies
Non small cell carcinoma lung
Gastrointestinal stromal tumours
Hepatocellular cancer
Renal cell carcinoma
Pancreatic cancer
Colorectal cancer
Ethosuximide is the drug of choice for treatment of ?
1) Generalized tonic clonic seizures
2) Absence seizures
3) Simple partial seizures
4) Complex partial seizures
Pharmacology Answer: 2
Ethosuximide is the drug of choice for treatment of absence seizures.
Other drugs used in the management of absence seizures are valproic acid, lamotrigine and clonazepam.
False statement regarding phenytoin is?
1) It is a teratogenic drug
2) Highly protein bound
3) Induces insulin secretion
4) Follows saturation kinetics
Pharmacology Answer: 3
Phenytoin inhibits insulin secretion and causes hyperglycemia.
Which of the following is used for the treatment of chlamydia infection in pregnancy?
1) Tetracycline
2) Erythromycin
3) Azithromycin
4) Doxycycline
Pharmacology Answer: 3
Azithromycin Preferred agent for treatment of chlamydia infection in pregnancy in azithromycin.
It is given as a single dose of 1g leading to high compliance rate.
Which of the following Antimicrobials has Antipseudomonal action:
1) Cefopodoxime proxetil
2) Ceforanide
3) Cefotetan
4) Cefoperazone
Pharmacology Answer: 4
Cephalosporins with antipseudomonal action:
Cefoperazone Ceftazidime