MDS PREP
Which of the following antihypertensive drugs should not be used in a patient on Lithium in order to prevent Lithium Toxicity?
1) Clonidine
2) Beta blockers
3) Calcium Channel Blockers
4) Diuretics
Pharmacology Answer: 4
Diuretics increase sodium loss in urine and increase lithium retention. Hence they should not be used in patients on Lithium.
Drug used in acute gout is?
1) Aspirin
2) Indomethacin
3) Phenylbutazone
4) Allopurinol
Pharmacology Answer: 4
Treatment of acute gout is mainly to control symptoms, i.e. pain, swelling etc.
The symptoms of acute gout are due to inflammation in the joints.
So, drugs which decrease inflammation are used in acute gout, i.e. anti-inflammatory drugs. Drugs are:- NSAIDs, Colchicine, Corticosteroids
Which of following statement about drug action is false ?
1) Competitive antagonist has no intrinsic activity but affinity
2) Competitive antagonist has intrinsic activity and affinity
3) Partial agonist has submaximal intrinsic activity and affinity
4) Inverse agonists have affinity but minus intrinsic activity.
Pharmacology Answer: 2
Competitive antagonists bind to receptors but do not activate them, meaning they have no intrinsic activity. They have affinity for the receptor, allowing them to compete with agonists for binding.
Morphine withdrawal is characterized by all except
1) Miosis
2) Yawning
3) Lacrimation
4) Diarrhea
Pharmacology Answer: 1
Withdrawal of morphine is associated with marked drug-seeking behavior.
Physical manifestations of abstinence are - lacrimation, sweating, yawning, anxiety, fear, restlessness, gooseflesh, mydriasis, tremor, insomnia, abdominal colic, diarrhea, dehydration, rise in BP, palpitation and rapid weight loss.
Delirium and convulsions are not a characteristic feature (contrast barbiturates) and are seen only occasionally.
Cardi-ovascular collapse and fatality are rare if supportive measures are instituted.
Penicillins:
1) Are the antibiotic of choice for anaerobic infections
2) Are bacteriostatic
3) Are protagonistic to tetracycline
4) Interfere with bacterial cell wall synthesis
Pharmacology Answer: 4
The penicillins all act by interfering with bacterial cell wall synthesis, by inhibiting cross-linking of the mucopeptides in the cell wall and as such are bacteriocidal. Bacteria are attacked when cells are dividing and so in theory antibiotics that are bacteriostatic would decrease the efficacy of bacteriocidal drugs. However, this doesn’t often cause a problem but tetracycline and penicillin are antagonistic and should not be used at the same time. Metronidazole is the antibiotic of choice for anaerobic infections.
The drug currently in wide use for treating opioid dependent individuals
1. methadone
2. pentazocine
3. alphaprodine
4. meperidine
Pharmacology
Answer: 1
The drug currently in wide use for treating opioid dependent individuals is metahdone
Syncope may be treated with any of the following drug except
1) Phenylephrine
2) Oxygen
3) Ephedrine
4) Isoproterenol
Pharmacology Answer: 4
Isoproterenol is used in the management of bronchospasm during anesthesia;
adjunctive treatment for shock.
One of the side-effects of prilocaine is
1) Gastric bleeding
2) Porphyria
3) Photophobia
4) Methemoglobinemia
Pharmacology Answer: 4
Methemoglobinemia is a condition in which the iron within hemoglobin is oxidized from the ferrous (Fe2+) state to the ferric (Fe3+) state, resulting in the inability to transport oxygen and carbon dioxide. Clinically, this condition causes cyanosis, often posing a diagnostic dilemma
usually results from exposure to oxidizing substances (such as nitrates or nitrites, aniline dyes, or medications, including lidocaine, prilocaine, phenazopyridine hydrochloride (Pyridium], and others)