MDS PREP
Which of the following is used in the treatment of meningococcal meningitis in patients allergic to penicillin?
1) Ciprofloxacin
2) Teicoplanin
3) Meropenem
4) Chloramphenicol
Pharmacology Answer: 4
Treatment of meningococcal meningitis:
Drug of choice – Penicillin G
In case of penicillin resistance, third generation cephalosporins should be used ( Ceftriaxone / CefotaximeIn case of penicillin / cephalosporin allergy, Chloramphenicol is used
Ethosuximide is the drug of choice for treatment of ?
1) Generalized tonic clonic seizures
2) Absence seizures
3) Simple partial seizures
4) Complex partial seizures
Pharmacology Answer: 2
Ethosuximide is the drug of choice for treatment of absence seizures.
Other drugs used in the management of absence seizures are valproic acid, lamotrigine and clonazepam.
Chelating agent contraindicated in iron and cadmium poisoning
1) Penicillamine
2) Des ferroxamine
3) EDTA
4) BAL
Pharmacology Answer: 4
Dimercaprol (British antilewisite; BAL)
1. Poisoning by As, Hg, Au, Bi, Ni, Sb: it is administered i.m., 5 mg/kg stat, followed by 2-3 mg/kg every 4 – 8 hours for 2 days, then once or twice a day for 10 days. It is partly oxidized and glucuronide conjugated, but mainly excreted as such in 4 – 6 hours. Earlier the treatment is instituted, the better it is. Because the dimercaprolmetal complex dissociates faster in acidic urine and the released metal can damage the kidney, urine is alkalinized during dimercaprol therapy.
2. As an adjuvant to Cal. Disod. Edentate in lead poisoning.
3. As an adjuvant to penicillamine in Cu poisoning and in Wilson’s disease – 300 mg/day i.m. for 10 days every second month.
It is contraindicated in iron and cadmium poisoning, because the dimercaprol-Fe and dimercaprol-Cd complex is itself toxic.
Morphine causes vomiting by
1. stimulation of the no dose ganglion of the vagus
2. direct stimulation of the gastrointestinal musculature
3. stimulation of the medullary chemo receptor trigger zone
4. a direct irritant action on the gastric mucosa.
Pharmacology
Answer: 3
Morphine causes vomiting by stimulation of the medullary chemo receptor trigger zone
The Nitrate which does not undergo first pass metabolism is:
1) Isosorbide mononitrate
2) Nitroglycerine
3) Pentaerythritol tetranitrate
4) Isosorbide dinitrate
Pharmacology Answer: 1
In humans, isosorbide mononitrate is not subject to first pass metabolism in the liver.
This reduces the intra- and interindividual variations in plasma evels and leads to predictable and reproducible clinical effects.
Drug implicated for prolonging QT interval in a premature baby is :
1) Domperidone
2) Metoclopramide
3) Cisapride
4) Omeprazole
Pharmacology Answer: 3
Cisapride can cause QT prolongation when administered along with drugs like ketoconazole which inhibit hepatic cytochrome p-450 CYP 3A4 enzyme.
Penicillins:
1) Are the antibiotic of choice for anaerobic infections
2) Are bacteriostatic
3) Are protagonistic to tetracycline
4) Interfere with bacterial cell wall synthesis
Pharmacology Answer: 4
The penicillins all act by interfering with bacterial cell wall synthesis, by inhibiting cross-linking of the mucopeptides in the cell wall and as such are bacteriocidal. Bacteria are attacked when cells are dividing and so in theory antibiotics that are bacteriostatic would decrease the efficacy of bacteriocidal drugs. However, this doesn’t often cause a problem but tetracycline and penicillin are antagonistic and should not be used at the same time. Metronidazole is the antibiotic of choice for anaerobic infections.
Which of the following statements is true regarding the phase III clinical trial of a drug?
1) It is intended to determine drug efficacy and toxicity on a large number of patients
2) It is performed only on primates
3) It is performed with only a few volunteer subjects
4) It is primarily intended to determine the LD50 of a drug
Pharmacology Answer: 1
Phase III studies are randomized controlled multicenter trials on large patient groups (300–3,000 or more depending upon the disease/medical condition studied) and are aimed at being the definitive assessment of how effective the drug is, in comparison with current 'gold standard' treatment.