MDS PREP
Which of the following agents is used for the treatment of Thrombocytopenia secondary to myelosuppressive cancer chemotherapy?
1) Filgrastim
2) Sargramostim
3) Oprelvekin
4) Erythropoietin
Pharmacology Answer: 3
Oprelvekin (Interleukin 11) is the only agent approved by the FDA for treatment of thrombocytopenia secondary to myelosuppressive cancer chemotherapy
Filgrastim (G-CSF) and Sargramostim (GM-SCF) are used in the treatment of neutropenia
Erythropoietin is used in treatment of anemia
The administration of penicillin G along with probenacid results in
1. increased excretion of probenacid in the feces and perspiration
2. increased excretion of probenacid in urine
3. increased metabolism of penicillin G
4. decreased renal excretion of penicillin G
Pharmacology Answer: 4
The administration of penicillin G along with probenacid results in decreased renal excretion of penicillin G
The penicillin with the best gram negative spectrum is
1. methicillin
2. phenethicillin
3. ampicillin
4. penicillin V
Pharmacology
Answer: 3
The penicillin with the best gram negative spectrum is ampicillin
Proton pump inhibitors are most effective when they are given
1) After meals
2) Shortly before meals
3) Along with H2 blockers
4) During prolonged fasting periods
Pharmacology Answer: 2
Bio-availability of all proton pump inhibitors is reduced by food; they should be taken in empty stomach, followed 1 hour later by a meal to activate H+K+ ATPase and make it more susceptible to the proton pump inhibitor.
Ethohepatazine is a chemical derivative of
1. codeine
2. morphine
3. meperidine
4. papaverine
Pharmacology
Answer: 3
Ethohepatazine is a chemical derivative of meperidine
The drug currently in wide use for treating opioid dependent individuals
1. methadone
2. pentazocine
3. alphaprodine
4. meperidine
Pharmacology
Answer: 1
The drug currently in wide use for treating opioid dependent individuals is metahdone
Tyrosine kinase inhibitors are useful in the management of ?
1) Acute myeloid leukemia
2) Small cell carcinoma of lung
3) Gastrointestinal stromal tumors
4) Neurofibromatosis
Pharmacology Answer: 3
Tyrosine kinase inhibitors are used in the treatment of:
Chronic myeloid leukemia
Acute lymphoblastic leukemia ( philadelphia chromosome positive cases )
Head and neck malignancies
Non small cell carcinoma lung
Gastrointestinal stromal tumours
Hepatocellular cancer
Renal cell carcinoma
Pancreatic cancer
Colorectal cancer
All of the following drugs cross the placenta except?
1) Phenytoin
2) Diazepam
3) Morphine
4) Heparin
Pharmacology Answer: 4
Heparin Heparin does not the cross the placenta.
Hence its safe for use in pregnant patients who need anticoagulation.