MDS PREP
In treatment of oral cancers, the fraction of total dose given in each appointment is in the range of
1. 150 rad
2. 300 rad
3. 400 rad
4. 500 rad
Oral Pathology
Answer: 1
In the treatment of oral cancers, the fraction of total dose given in each appointment is typically around 150 rad.
Oral manifestation of infectious mononucleosis is most commonly
1. Bluish red spots opposite maxillary molar
2. Pseudomembrane on gingival
3. Pinpoint petechiae on the palate
4. Gingival hyperplasia
Oral Pathology
Answer: 3
Pinpoint petechiae on the palate is the most common oral manifestation of infectious mononucleosis.
The peripheral blood smear of a patient shows features of thalassemia, also presented with anemia. Family history is also +ve. The investigation was done to establish the diagnosis is -
1) ESR estimation
2) Blood spherocyte estimation
3) Bone marrow aspiration
4) Hb-electrophoresis
General Pathology
Answer: 4
Hb-electrophoresis is the investigation done to establish the diagnosis of thalassemia, as it separates different hemoglobin types based on their charge.
The major stimulator of monocytes
1. IL-I
2. ã-interferon
3. IgE
4. lgG
Pathology Answer: 1
1. Interleukin-1 (IL-1): Interleukin-1 is a pro-inflammatory cytokine that
plays a crucial role in the activation and regulation of the immune system. It
is produced mainly by macrophages and monocytes in response to various stimuli,
including bacterial endotoxins, viruses, and tissue damage. IL-1 is a major
stimulator of monocytes, as it promotes their proliferation, differentiation
into macrophages, and enhances their phagocytic and antigen-presenting
capabilities. It also induces the production of other cytokines, such as
TNF-alpha and IL-6, which further amplify the inflammatory response. Thus, it
acts as a critical mediator in the early stages of the immune response and is
involved in the initiation of the acute phase reaction.
2. α-Interferon: Interferons (IFNs) are a family of cytokines that play an
essential role in the innate immune response to viral infections. They are
mainly produced by cells in response to viral infection and can induce an
antiviral state in nearby cells by upregulating the expression of proteins that
inhibit viral replication. While α-interferon does not directly stimulate
monocytes, it does have some effects on the immune system, such as enhancing the
natural killer (NK) cell activity and modulating the function of macrophages and
other immune cells. However, it is not the primary stimulator of monocytes like
IL-1 is.
3. Immunoglobulin E (IgE): IgE is a class of antibodies that are involved in the
allergic response and the immune response to parasites. It is produced in
response to allergens and parasitic antigens. While IgE is important in the
activation of mast cells and basophils, which play a key role in the immediate
allergic response, it does not serve as a major stimulator of monocytes.
Monocytes are more closely associated with the innate immune response and are
not primarily activated by antibodies.
4. Immunoglobulin G (IgG): IgG is the most abundant and versatile class of
antibodies in the blood. It plays a pivotal role in the immune response by
binding to pathogens and facilitating their destruction through various
mechanisms, such as opsonization (enhancing phagocytosis), activation of the
complement system, and neutralization of toxins. IgG can interact with
macrophages via Fcγ receptors, which can lead to phagocytosis of
antigen-antibody complexes. However, IgG is not a direct stimulator of monocytes
in the same sense that IL-1 is. Monocytes are primarily activated by cytokines
and other signaling molecules released during inflammation and infection, rather
than by antibodies.
The oral lesion of warty dsykeratoma is described as
1. a small whitish area of the mucosa with a central depression
2. a hyperemic papule with erosion
3. an erythematous macule with a central area of grayish desquamation
4. a white keratotic. papillary or verrucous lesion
Oral Pathology
Answer: 1
The oral lesion of warty dsykeratoma is described as a small whitish area of the mucosa with a central depression
The substance most commonly used for protection against X-ray radiations is
1. Zinc
2. Steel
3. Lead
4. Porcelain
Oral Pathology
Answer: 3
Lead is the most commonly used substance for protection against X-ray radiation.
Indirect chemical carcinogens differ from direct acting agents in those
indirect agents:
1. Induce carcinogenicity without chemical transformation
2. Induce carcinogenicity after chemical transformation
3. Don’t require metabolic conversion
4. None of the above
Pathology Answer: 2
Indirect chemical carcinogens differ from direct acting agents in that they
require metabolic activation to exert their carcinogenic effects. This means
that indirect carcinogens must undergo a chemical transformation within the body
before they can damage DNA and induce cancer. Direct acting carcinogens, on the
other hand, can interact directly with DNA without the need for metabolic
conversion. Therefore, the correct answer is:
2. Induce carcinogenicity after chemical transformation
1. Induce carcinogenicity without chemical transformation: This statement is
incorrect for indirect chemical carcinogens. Indirect carcinogens are typically
non-reactive or less reactive in their original form and must undergo metabolic
activation to become DNA-reactive. This metabolic conversion is crucial for
their carcinogenic potential.
2. Induce carcinogenicity after chemical transformation: This is the correct
explanation. Indirect carcinogens require metabolic activation by the body's
enzyme systems, particularly phase I enzymes such as cytochrome P450, to convert
them into electrophilic or reactive intermediates that can interact with DNA.
This activation process can occur in various tissues, often the liver, where
these enzymes are present. The reactive metabolites then form DNA adducts, which
can lead to mutations and ultimately cancer if not repaired properly by the
cell's DNA repair mechanisms.
3. Don’t require metabolic conversion: This statement is incorrect. Indirect
carcinogens do require metabolic conversion to become active carcinogens. It is
the direct acting carcinogens that can interact with DNA without the need for
such activation because they are already electrophilic or reactive in their
original form.
Lichenoid reactions are mainly due to
1. Intake of certain drugs
2. Betel nut chewing
3. Cigarette smoking
4. Intake of alcohol
Oral Pathology
Answer: 1
Lichenoid reactions are mainly due to the intake of certain drugs.