The primary canine is usually exfoliated between the ages of 10 and 11 years

Sometimes, mineralization of dentin begins in small globular areas that fail to coalesce into a homogenous mass. This results in zones of hypomineralization between the globules.
These zones are known as globular dentin or interglobular spaces. Thus, demonstrating defect of mineralization and not of matrix formation, the dentinal tubules pass uninterruptedly through interglobular dentin.

A mandibular primate space is usually found in the primary dentition between canine and first molar

Dentinogenesis is the formation of dentin by odontoblasts of mesenchymal origin located at the periphery of the dental pulp

Dentinogenesis is initiated by the inductive influence of the enamel organ involving molecular signaling pathways, such as Wnt, Runx-2, and TGF-?. In the molar tooth, dentinogenesis starts at the late bell stage, and occurs in the crown as well as root regions.

Predentin, the first organic matrix secreted by odontoblasts, is composed by proteoglycans, glycoproteins, and collagens.

A tooth makes its appearance in the oral cavity usually when one half of the root is completed