The Glasgow Coma Scale (GCS) is widely used to assess the severity of coma or impaired consciousness, particularly in patients with head injuries.

While Zollinger Ellison syndrome is primarily associated with gastrinomas, these tumors can be malignant and can metastasize. The most common malignant counterpart is pancreatic adenocarcinoma, which can be found in about 25% of cases.

In renal impairment, the time to reach steady-state plasma concentration generally differs from that in patients with normal renal function due to altered clearance; hence, statement 3 is incorrect.

Renin is an enzyme secreted by the juxtaglomerular cells of the kidneys in response to low blood pressure or low sodium concentration.

The nephrotic syndrome includes massive proteinuria, hypoalbuminemia, generalized edema, and hyperlipidemia with lipiduria. Neutrophiluria, the presence of neutrophils in the urine, is not a typical feature of the nephrotic syndrome and is more associated with conditions like acute glomerulonephritis or pyelonephritis.