In the initial phase of treatment for hemochromatosis, phlebotomy is usually performed once a week to rapidly reduce iron stores. Once transferrin saturation and serum ferritin levels become normal, the frequency is typically reduced to every three months for maintenance.

A gastrinoma is a non-beta cell tumor that autonomously produces large amounts of gastrin, leading to hypergastrinemia and increased acid secretion in the stomach, resulting in severe peptic ulcers.

E. coli O157:H7 is the most commonly identified serotype of EHEC and is associated with outbreaks related to the consumption of inadequately cooked ground beef, milk, and vegetables. It produces Shiga-like toxins, which can cause hemolytic uremic syndrome.

Adrenaline is the drug of choice in anaphylactic shock as it acts rapidly to counteract the effects of histamine by causing vasoconstriction and bronchodilation. It is administered intramuscularly to ensure quick absorption and action.

The GBM is a critical component of the glomerular filtration barrier that normally prevents the passage of proteins into the urine. In the nephrotic syndrome, there are alterations in the GBM that lead to increased permeability and loss of proteins, particularly albumin, into the glomerular filtrate.