MDS PREP
Protamine sulphate reverses the effect of
1) Meperidine
2) Atropine
3) Hepartn
4) Strychnine.
Pharmacology Answer: 3
Heparin-associated thrombocytopenia may be associated with irreversible aggregation of platelets and treating venous thromboembolism. The incidence of thrombocytopenia after administration of LMWH is lower than with standard heparin. Adverse drug reactions like those caused by standard heparin have been seen during therapy with LMWH, and overdose is treated with protamine.
Which of the following is used to decrease the toxicity of amphotericin B?
1) Dose reduction
2) Liposomal delivery systems
3) Supplementing glucose
4) Giving it along with flucytosine
Pharmacology Answer: 2
Liposomal delivery systems decrease the amount of free drug in the blood Infected cells interact with the liposomes, resulting in the release of amphotericin B at the site of action.
Not a contraindication for epinephrine use is
1) Heart disease.
2) Hypersensitivity to drug.
3) Hyperthyroidism.
4) Liver disease.
Pharmacology Answer: 4
Adrenaline is contraindicated in hypertensive, hyperthyroid and angina patient.
Hypersensitivity to drug is absolute contraindication to any drug.
The Nitrate which does not undergo first pass metabolism is:
1) Isosorbide mononitrate
2) Nitroglycerine
3) Pentaerythritol tetranitrate
4) Isosorbide dinitrate
Pharmacology Answer: 1
In humans, isosorbide mononitrate is not subject to first pass metabolism in the liver.
This reduces the intra- and interindividual variations in plasma evels and leads to predictable and reproducible clinical effects.
Which of following statement about drug action is false ?
1) Competitive antagonist has no intrinsic activity but affinity
2) Competitive antagonist has intrinsic activity and affinity
3) Partial agonist has submaximal intrinsic activity and affinity
4) Inverse agonists have affinity but minus intrinsic activity.
Pharmacology Answer: 2
Competitive antagonists bind to receptors but do not activate them, meaning they have no intrinsic activity. They have affinity for the receptor, allowing them to compete with agonists for binding.
The cause of death with opioid intoxication is
1. respiratory depression
2. cardiac arrest
3. terminal convulsions
4. oxygen apnea
Pharmacology
Answer: 1
The cause of death with opioid intoxication is respiratory depression
Which of the following is not an analeptic agent
1. Doxapram
2. Nikethamide
3. Doxacurium
4. Propylbutamide
Pharmacology
Answer: 3
Which muscle relaxant increases intracranial pressure
1. Mivacurium
2. Atracurium
3. Suxamethonium
4. Vecuronium