MDS PREP
Which of the following agents is used for the treatment of Thrombocytopenia secondary to myelosuppressive cancer chemotherapy?
1) Filgrastim
2) Sargramostim
3) Oprelvekin
4) Erythropoietin
Pharmacology Answer: 3
Oprelvekin (Interleukin 11) is the only agent approved by the FDA for treatment of thrombocytopenia secondary to myelosuppressive cancer chemotherapy
Filgrastim (G-CSF) and Sargramostim (GM-SCF) are used in the treatment of neutropenia
Erythropoietin is used in treatment of anemia
False statement regarding phenytoin is?
1) It is a teratogenic drug
2) Highly protein bound
3) Induces insulin secretion
4) Follows saturation kinetics
Pharmacology Answer: 3
Phenytoin inhibits insulin secretion and causes hyperglycemia.
Ambroxol is a :
1) Mucolytic agent
2) Bronchial secretion enhancer
3) Antitussive
4) None of the above
Pharmacology Answer: 1
Expectorants (Mucokinetics)
(a) Bronchial secretion enhancers : Sodium or Potassium citrate, Potassium iodide, Guaiphenesin (Glyceryl guaiacolate), balsum of Tolu, Vasaka, Ammonium chloride.
(b) Mucolytics: Bromhexine Ambroxol Acetyl cysteine Carbocisteine
The antibiotic of choice in acute epiglottitis culture sensitivity report is -
1. Erythromycin
2. Rolitetracycline
3. Doxycycline
4. Ampicillin
Pharmacology
Answer: 4
Ampicillin is the antibiotic of choice for acute epiglottitis based on culture sensitivity.
Which of the following antihypertensive drugs should not be used in a patient on Lithium in order to prevent Lithium Toxicity?
1) Clonidine
2) Beta blockers
3) Calcium Channel Blockers
4) Diuretics
Pharmacology Answer: 4
Diuretics increase sodium loss in urine and increase lithium retention. Hence they should not be used in patients on Lithium.
Which of the following are anti-fungal drugs?
1) Cloxacillin
2) Aciclovir
3) Chlorhexidine
4) Nystatin
Pharmacology Answer: 4
Miconazole is an imidazole anti-fungal drug, Nystatin is a polyene anti-fungal drug and itraconazole is a triazole anti-fungal.
Aciclovir is an anti-viral drug and chlorhexidine is an antiseptic.cloxacillin is penicillin derivative.
Permanent auditory nerve deafness is frequently associated with use of
1. tetracycline
2. penicillin
3. bacitracin
4. streptomycin
Pharmacology
Answer: 4
Permanent auditory nerve deafness is frequently associated with use of streptomycin
Ipratropium bromide is useful in bronchial asthma because of
1) Anticholinergic effect
2) Vasodilator properties
3) Antiallergic action
4) Stabilization of mast cells
Pharmacology Answer: 1
Ipratropium (as ipratropium bromide, trade name Atrovent) is an anticholinergic drug administered by inhalation for the treatment of obstructive lung diseases.
It acts by blocking muscarinic receptors in the lung, inhibiting bronchoconstriction and mucus secretion.
It is a non-selective muscarinic antagonist, and does not diffuse into the blood, which prevents systemic side effects.
Ipratropium is a derivative of atropine[1] but is a quaternary amine and therefore does not cross the blood-brain barrier