MDS PREP
Which of the following agents is used for the treatment of Thrombocytopenia secondary to myelosuppressive cancer chemotherapy?
1) Filgrastim
2) Sargramostim
3) Oprelvekin
4) Erythropoietin
Pharmacology Answer: 3
Oprelvekin (Interleukin 11) is the only agent approved by the FDA for treatment of thrombocytopenia secondary to myelosuppressive cancer chemotherapy
Filgrastim (G-CSF) and Sargramostim (GM-SCF) are used in the treatment of neutropenia
Erythropoietin is used in treatment of anemia
Which of the following action is ascribed to delta type of opioid receptors?
1) Supraspinal analgesis
2) Respiratory depression
3) Euphoria
4) Reduced intestinal motility
Pharmacology Answer: 1
Functions of delta type opioid receptors are:
supraspinal analgesia
spinal analgesia
modulation of hormone and neurotransmitter release
The effects of hypoglycemia is marked by
1) Warfarin
2) Beta blockers
3) Calcium channel blockers
4) Amino glycosides
Pharmacology Answer: 2
Beta blockers
Hypoglycemia can occur with beta-blockade because b2- adrenoceptors normally stimulate hepatic glycogen breakdown (glycogenolysis) and pancreatic release of glucagon, which work together to increase plasma glucose.
Which of the following is not a loop diuretic:
1) Fruesmide
2) Torsemide
3) Ethacrynic acid
4) Chlorthalidone
Pharmacology Answer: 4
Chlorthalidone (Thiazide like diuretic)
Morphine causes vomiting by
1. stimulation of the no dose ganglion of the vagus
2. direct stimulation of the gastrointestinal musculature
3. stimulation of the medullary chemo receptor trigger zone
4. a direct irritant action on the gastric mucosa.
Pharmacology
Answer: 3
Morphine causes vomiting by stimulation of the medullary chemo receptor trigger zone
The main excitatory neuro transmitter in CNS is
1) Glycine
2) Acetyl choline
3) Aspartate
4) Glutamate
Pharmacology Answer: 2
The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS)and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmiter used in the somatic nervous system.
Albendazole is effective against infection with all of the following except-
1. Ascariasis
2. Neurocysticercosis
3. Echinococcus granulosus
4. Schistosomiasis
Pharmacology
Answer: 4
Albendazole is not effective against Schistosomiasis, which is caused by a parasitic worm.
Which of the following statements is true regarding the phase III clinical trial of a drug?
1) It is intended to determine drug efficacy and toxicity on a large number of patients
2) It is performed only on primates
3) It is performed with only a few volunteer subjects
4) It is primarily intended to determine the LD50 of a drug
Pharmacology Answer: 1
Phase III studies are randomized controlled multicenter trials on large patient groups (300–3,000 or more depending upon the disease/medical condition studied) and are aimed at being the definitive assessment of how effective the drug is, in comparison with current 'gold standard' treatment.