MDS PREP
Rapid induction of anaesthesia occurs with which of the following inhalational anaesthetics
1. Isoflurane
2. Halothane
3. Desflurane
4. Sevoflurane
less solublity in blood means more rapid induction, however quicker emergence after discontinuing depends upon solublity and redistribution in lipids of body as well
Drug used in acute gout is?
1) Aspirin
2) Indomethacin
3) Phenylbutazone
4) Allopurinol
Pharmacology Answer: 4
Treatment of acute gout is mainly to control symptoms, i.e. pain, swelling etc.
The symptoms of acute gout are due to inflammation in the joints.
So, drugs which decrease inflammation are used in acute gout, i.e. anti-inflammatory drugs. Drugs are:- NSAIDs, Colchicine, Corticosteroids
Chlortetracycline acts by interfering with
1. protein synthesis on bacterial but not mammalian ribosomes
2. cell wall synthesis
3. nucleic acid synthesis
4. protein synthesis on mammalian but not bacterial ribosomes
Pharmacology
Answer: 1
Chlortetracycline acts by interfering with protein synthesis on bacterial but not mammalian ribosomes
Which of the following has a uricosuric action:
1) Allopurinol
2) Losartan
3) Ramipril
4) Atenolol
Pharmacology Answer: 2
Losartan has a uricosuric action in addition to being an angiotensin receptor blocker.
Allopurinol is a xanthine oxidase inhibitor which reduces the synthesis of uric acid.
Morphine withdrawal is characterized by all except
1) Miosis
2) Yawning
3) Lacrimation
4) Diarrhea
Pharmacology Answer: 1
Withdrawal of morphine is associated with marked drug-seeking behavior.
Physical manifestations of abstinence are - lacrimation, sweating, yawning, anxiety, fear, restlessness, gooseflesh, mydriasis, tremor, insomnia, abdominal colic, diarrhea, dehydration, rise in BP, palpitation and rapid weight loss.
Delirium and convulsions are not a characteristic feature (contrast barbiturates) and are seen only occasionally.
Cardi-ovascular collapse and fatality are rare if supportive measures are instituted.
Albendazole is effective against infection with all of the following except-
1. Ascariasis
2. Neurocysticercosis
3. Echinococcus granulosus
4. Schistosomiasis
Pharmacology
Answer: 4
Albendazole is not effective against Schistosomiasis, which is caused by a parasitic worm.
Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of < 50mg/min?
1) Ciprofloxacin
2) Trovafloxacin
3) Lomefloxacin
4) Sparfloxacin
Pharmacology Answer: 2
Fluoroquinolones that are excreted mainly by non renal mechanisms:
Pefloxacin Trovafloxacin Grepofloxacin Nalidixic acid
Drug class causing free water clearance:
a) Diuretic
b) Saluretic
c) Uricosuric
d) Aquaretic
Pharmacology Answer: 4
Vasopressin antagonists like tolvaptan are aquaretics