MDS PREP
Which of the following antiviral drugs cannot be given orally?
1) Zidovudine
2) Zalcitabine
3) Acyclovir
4) Iodoxuridine
Pharmacology Answer: 4
Idoxuridine acts as an antiviral agent against DNA viruses by inhibiting thymidilate phosphorylase and viral DNA polymerases.
The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.
This product is available in the following dosage forms:Solution and Ointment
Which of the following is a Beta-1 selective blocker ?
1) propranolol
2) nadolol
3) pindolol
4) betaxolol
Pharmacology Answer: 4
Beta-1 selective blockers
These include atenolol and metoprolol (as well as betaxolol, bevantolol, and perhaps esmolol).
Non-selective beta blockers
propranolol
Ethosuximide is the drug of choice for treatment of ?
1) Generalized tonic clonic seizures
2) Absence seizures
3) Simple partial seizures
4) Complex partial seizures
Pharmacology Answer: 2
Ethosuximide is the drug of choice for treatment of absence seizures.
Other drugs used in the management of absence seizures are valproic acid, lamotrigine and clonazepam.
Ipratropium bromide is useful in bronchial asthma because of
1) Anticholinergic effect
2) Vasodilator properties
3) Antiallergic action
4) Stabilization of mast cells
Pharmacology Answer: 1
Ipratropium (as ipratropium bromide, trade name Atrovent) is an anticholinergic drug administered by inhalation for the treatment of obstructive lung diseases.
It acts by blocking muscarinic receptors in the lung, inhibiting bronchoconstriction and mucus secretion.
It is a non-selective muscarinic antagonist, and does not diffuse into the blood, which prevents systemic side effects.
Ipratropium is a derivative of atropine[1] but is a quaternary amine and therefore does not cross the blood-brain barrier
All of the following drugs cross the placenta except?
1) Phenytoin
2) Diazepam
3) Morphine
4) Heparin
Pharmacology Answer: 4
Heparin Heparin does not the cross the placenta.
Hence its safe for use in pregnant patients who need anticoagulation.
Developed hypo reactivity to a drug is
1) Detoxification
2) Antagonism
3) Tolerance
4) Desensitization
Pharmacology Answer: 3
Tolerance: The capacity to absorb a drug continuously or in large doses without adverse effect; diminution in the response to a drug after prolonged use.
Not a contraindication for epinephrine use is
1) Heart disease.
2) Hypersensitivity to drug.
3) Hyperthyroidism.
4) Liver disease.
Pharmacology Answer: 4
Adrenaline is contraindicated in hypertensive, hyperthyroid and angina patient.
Hypersensitivity to drug is absolute contraindication to any drug.
The effects of hypoglycemia is marked by
1) Warfarin
2) Beta blockers
3) Calcium channel blockers
4) Amino glycosides
Pharmacology Answer: 2
Beta blockers
Hypoglycemia can occur with beta-blockade because b2- adrenoceptors normally stimulate hepatic glycogen breakdown (glycogenolysis) and pancreatic release of glucagon, which work together to increase plasma glucose.