MDS PREP
The main excitatory neuro transmitter in CNS is
1) Glycine
2) Acetyl choline
3) Aspartate
4) Glutamate
Pharmacology Answer: 2
The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS)and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmiter used in the somatic nervous system.
Which of the following statements is true regarding the phase III clinical trial of a drug?
1) It is intended to determine drug efficacy and toxicity on a large number of patients
2) It is performed only on primates
3) It is performed with only a few volunteer subjects
4) It is primarily intended to determine the LD50 of a drug
Pharmacology Answer: 1
Phase III studies are randomized controlled multicenter trials on large patient groups (300–3,000 or more depending upon the disease/medical condition studied) and are aimed at being the definitive assessment of how effective the drug is, in comparison with current 'gold standard' treatment.
The cause of death with opioid intoxication is
1. respiratory depression
2. cardiac arrest
3. terminal convulsions
4. oxygen apnea
Pharmacology
Answer: 1
The cause of death with opioid intoxication is respiratory depression
Which of the following statements is not true regarding sulfonamides:
1) Sulfasalazine is absorbed well from GIT
2) Crystalluria can occur with sulfonamide administration
3) Sulfonamide administration to Newborn may cause Kernicterus
4) Sulfonamides are of value in treatment of infections due to Norcardia species
Pharmacology Answer: 1
Sulfasalazine is absorbed well from GIT
Sulfasalazine is poorly absorbed (10-20%) from the GIT .
Dry mouth during antidepressant therapy is caused by blockade of:
1) Muscarinic acetylcholine receptors.
2) Serotonergic receptors.
3) Dopaminergic receptors.
4) GABA receptors.
Pharmacology Answer: 1
Anticholinergic side effect of antidepressant leads to dry mouth in the patients on these drugs.
Dry mouth is due to the Muscarinic acetylcholine receptor antagonism of these drugs.
The primary agent used in the treatment of trigeminal neuralgia is
1. diazepam
2. phenytoin
3. phenobarbital
4. carbamazepine
Pharmacology
Answer: 4
carbamazepine is the primary agent used in
ment of trigeminal neuralgia
Chlortetracycline acts by interfering with
1. protein synthesis on bacterial but not mammalian ribosomes
2. cell wall synthesis
3. nucleic acid synthesis
4. protein synthesis on mammalian but not bacterial ribosomes
Pharmacology
Answer: 1
Chlortetracycline acts by interfering with protein synthesis on bacterial but not mammalian ribosomes
Nonselective beta blocker possessing quinidine-like membrane stabilizing effects.
1) pindolol
2) acebutolol
3) sotalol
4) esmolol
Pharmacology Answer: 1
Beta-blockers, such as propranolol, labetalol, and pindolol, can have membrane stabilizing effects (eg, quinidinelike effects, Vaughan-Williams class I antiarrhythmic effects). This property, usually not evident with therapeutic doses, may significantly contribute to toxicity by prolonging QRS duration and impairing cardiac conduction. Seizures are more commonly observed in the drugs with quinidinelike membrane stabilizing effects.