MDS PREP
A medication that reduces the rate of aqueous humor formation in acute glaucoma
1) phenothiazines
2) amphotericin B
3) Isoniazid
4) carbonic anhydrase inhibitors
Pharmacology Answer: 4
Carbonic anhydrase is found in erythrocytes, kidney, gut, ciliary body, choroid plexus, and glial cells.
Carbonic anhydrase inhibitors are used primarily as probes for studying renal transport mechanisms and in the treatment of glaucoma
When used to treat glaucoma, carbonic anhydrase inhibitors diminish the transport of HCO3 - and Na+ by the ciliary process, which limits intraocular pressure.
This reduces the formation of aqueous humor by up to 50%, thereby reducing the intraocular pressure. These agents can also limit CSF and endolymph formation.
Which one of the following drugs increases gastrointestinal motility?
1) Glycopyrrolate.
2) Atropine.
3) Neostigmine.
4) Fentanyl.
Pharmacology Answer: 3
Synthetic opioids, sharing properties of opium and morphine, include meperidine, propoxyphene, diphenoxylate, fentanyl, buprenorphine, methadone, and pentazocine. Various opiate effects are analgesia, respiratory depression, constipation, and euphoria.
Fentanyl (80 to 100 times more powerful than morphine) is especially dangerous.
Atropine blocks the muscarinic receptors. Atropine decreases gastrointestinal tract motility and secretion and causes constipation.
Although various derivatives and congeners of atropine (such as propantheline, isopropamide, and glycopyrrolate) have been advocated in patients with peptic ulcer or with diarrheal syndromes
Neostigmine is Cholinesterase inhibitors that enhance the effects of parasympathetic stimulation and leads to reversal of intoxication by agents with a anticholinergic action
Which drug is most effective in reducing mortality in patients with left ventricular systolic dysfunction ?
1) Enalapril
2) Aspirin
3) Digoxin
4) Frusemide
Pharmacology Answer: 1
ACE inhibition has a beneficial impact on survival rates, functional status, and hemodynamics in patients with left ventricular systolic dysfunction.
In the renin-angiotensin system, a fall in perfusion pressure stimulates the juxtaglomerular cells in the kidney to release the enzyme renin.
Renin cleaves the decapeptide angiotensin I from angiotensinogen, a glycoprotein synthesized in the liver.
The octapeptide angiotensin II is formed by the action of ACE on angiotensin I.
Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone and norepinephrine.
The effects of hypoglycemia is marked by
1) Warfarin
2) Beta blockers
3) Calcium channel blockers
4) Amino glycosides
Pharmacology Answer: 2
Beta blockers
Hypoglycemia can occur with beta-blockade because b2- adrenoceptors normally stimulate hepatic glycogen breakdown (glycogenolysis) and pancreatic release of glucagon, which work together to increase plasma glucose.
Following drug interact with cefotaxime?
1) Digoxin
2) Paracetamol
3) Loop diuretics
4) Nifedipine
Pharmacology Answer: 3
Nephrotoxicity of cephalosporins is accentuated by concurrent administration of loop diuretics.
Tyrosine kinase inhibitors are useful in the management of ?
1) Acute myeloid leukemia
2) Small cell carcinoma of lung
3) Gastrointestinal stromal tumors
4) Neurofibromatosis
Pharmacology Answer: 3
Tyrosine kinase inhibitors are used in the treatment of:
Chronic myeloid leukemia
Acute lymphoblastic leukemia ( philadelphia chromosome positive cases )
Head and neck malignancies
Non small cell carcinoma lung
Gastrointestinal stromal tumours
Hepatocellular cancer
Renal cell carcinoma
Pancreatic cancer
Colorectal cancer
The cause of death with opioid intoxication is
1. respiratory depression
2. cardiac arrest
3. terminal convulsions
4. oxygen apnea
Pharmacology
Answer: 1
The cause of death with opioid intoxication is respiratory depression
A dental patient on clonidine therapy for hypertension most often complains of
1) Xerostomia
2) Frequent visit to the bathroom
3) Restlessness
4) Postural hypertension
Pharmacology Answer: 1
Clonidine cause significant CNS depression and xerostomia