MDS PREP
The Nitrate which does not undergo first pass metabolism is:
1) Isosorbide mononitrate
2) Nitroglycerine
3) Pentaerythritol tetranitrate
4) Isosorbide dinitrate
Pharmacology Answer: 1
In humans, isosorbide mononitrate is not subject to first pass metabolism in the liver.
This reduces the intra- and interindividual variations in plasma evels and leads to predictable and reproducible clinical effects.
Rapid induction of anaesthesia occurs with which of the following inhalational anaesthetics
1. Isoflurane
2. Halothane
3. Desflurane
4. Sevoflurane
less solublity in blood means more rapid induction, however quicker emergence after discontinuing depends upon solublity and redistribution in lipids of body as well
A medication that may elicit headache as a side effect :
1) thiazide
2) Methyldopa
3) hydralazine
4) Procainamide
Pharmacology Answer: 3
A number of medications may elicit headache as a side effect.
Common offenders include nitroglycerin, hydralazine, calcium-channel blockers, digitalis, and estrogen.
Recreational drugs such as nicotine, alcohol, marijuana, and amphetamines can also induce headache.
Alkalinization of urine is done during administration of which of the following chemotherapeutic drugs?
1) Ara-C (Cytarabine)
2) Methotrexate
3) Cisplatin
4) Ifosfamide
Pharmacology Answer: 2
Alkalinization of urine is used in patients receiving high dose methotrexate to promote renal excretion and to avoid nephrotoxicity
IV Sodium bicarbonate is used to maintain urine pH above 7.0 to avoid precipitation of methotrexate (a weak acid) in the acid pH of renal tubules
Drug class causing free water clearance:
a) Diuretic
b) Saluretic
c) Uricosuric
d) Aquaretic
Pharmacology Answer: 4
Vasopressin antagonists like tolvaptan are aquaretics
Heparin
1) is a glycosaminoglycan
2) potentiates thrombin
3) has a half life of 3-4 hours
4) is normally given IM
Pharmacology Answer: 1
GlycosaminoglycAnswer (GAGs) are heteropolysaccharides. These molecules are long unbranched polysaccharides containing a repeating disaccharide unit. The disaccharide units contain either of two modified sugars N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc) and a uronic acid such as glucuronate or iduronate. The specific GAGs of physiological significance are hyaluronic acid, dermatan sulfate, chondroitin sulfate, heparin, heparan sulfate, and keratan sulfate.
Which of the following is not a loop diuretic:
1) Fruesmide
2) Torsemide
3) Ethacrynic acid
4) Chlorthalidone
Pharmacology Answer: 4
Chlorthalidone (Thiazide like diuretic)
Albendazole is effective against infection with all of the following except-
1. Ascariasis
2. Neurocysticercosis
3. Echinococcus granulosus
4. Schistosomiasis
Pharmacology
Answer: 4
Albendazole is not effective against Schistosomiasis, which is caused by a parasitic worm.