MDS PREP
Defect leading to thalassemia lies in -
1) Haemoglobin
2) Osmotic fragility
3) RBC membrane
4) Platelets
General Pathology
Answer: 1
The defect leading to thalassemia lies in the hemoglobin itself, specifically in the globin chain synthesis.
Dens in dente is thought to arise as a result of
1. a normal tooth but enclaved within an other tooth, during formation
2. proliferation and evagination of an area of the inner enamel epithelium
3. extensive growth of mesenchymal cells of pulp tissue
4. an invagination of the enamel organ during tooth formation
Oral Pathology
Answer: 4
Dens in dente is a rare developmental dental anomaly that is characterized by a tooth with an invaginated or cavity-like structure that appears like a "tooth within a tooth." It arises from an error during the morphodifferentiation stage of tooth development.
Biochemical abnormality associated with osteogenesis imperfecta is increase in
1. Alkaline phosphatase
2. Acid phosphatase
3. Bicarbonate ion
4. Phosphorylase enzyme
The biochemical abnormality associated with osteogenesis imperfecta is an increase in acid phosphatase.
Which of the following diseases of the skin is the most likely to exhibit fluid blisters on the skin and/or oral mucosa?
1) Pemphigus
2) Lichen planus
3) Keratosis follicularis
4) Erythema multiforme
Oral Pathology
Answer: 1
Pemphigus is an autoimmune blistering disease characterized by the formation of bullae (fluid-filled blisters) on the skin and mucous membranes, including the oral mucosa. This condition occurs when the body's immune system mistakenly attacks the proteins that bind the layers of the skin together, leading to separation and blistering. The blisters are usually large and painful, and they can rupture easily, leaving raw, exposed areas of skin or mucous membrane.
Lichen planus, keratosis follicularis, and erythema multiforme are other skin conditions but do not typically present with fluid blisters as the main feature.
Which of the following is associated with a low concentration of ionized calcium in the serum?
1. Hypothyroidism
2. Osteogenesis imperfecta
3. Paget"s disease of the bone
4. Tetany
Oral Pathology
Answer: 4
Tetany is associated with a low concentration of ionized calcium in the serum.
Which of the following is responsible for autoimmunity in Epstein-Barr virus infection?
1) Molecular mimicry
2) Polyclonal B-cell activation
3) Upregulation of co-stimulatory molecules
4) Antigenic cross-reactivity
General Pathology
Answer: 2
Polyclonal B-cell activation is responsible for autoimmunity in Epstein-Barr virus infection, leading to various autoimmune manifestations.
Lichenoid reactions are mainly due to
1. Intake of certain drugs
2. Betel nut chewing
3. Cigarette smoking
4. Intake of alcohol
Oral Pathology
Answer: 1
Lichenoid reactions are mainly due to the intake of certain drugs.
Paroxymal noctural hemoglobinuria is due to -
1) Acquired red cell defect
2) Congential red cell defect
3) Auto immune defect
4) Lead poisoning
General Pathology
Answer: 1
Paroxysmal nocturnal hemoglobinuria is due to an acquired red cell defect, specifically a defect in the cell membrane that makes red blood cells susceptible to lysis.