MDS PREP
An important rate limiting step of Kreb's cycle is catalysed by
1. pyruvate dehydrogenase
2. isocitrate dehydrogenase
3. succinate dehydrogenase
4. citrate synthetase
Biochemistry Answer: 2
Rate limiting step of Kreb's cycle is catalysed by isocitrate dehydrogenase
Site of â-oxidation of fatty acid Is:
1. Cytoplasm
2. Mitochondria
3. Both cytoplasm and mitochondria
4. Lysosomes
Biochemistry
Answer: 2
â-oxidation of fatty acid occursin Mitochondria
Glutamate-pyruvate trans-aminase is predominantly present In:
1. Skeletal muscle
2. Cardiac muscle
3. Brain
4. Liver
Biochemistry
Answer: 4
Glutamate-pyruvate trans-aminase is predominantly present In Liver
An alpha helix of a protein is most likely to be disrupted if a missense mutation introduces the following armino acid within the alpha helical structure:
1. Alanine.
2. Aspartic acid.
3. Tyrosine.
4. Glycine.
Glycine and proline introduce a bend in structure of protein, hence alpha helix disrupted
Which of the following enzymes is active in adipocytes following a heavy meal?
1) Glycogen phosphorylase
2) Glycerol kinase
3) Hormone-sensitive triacylglyceride lipase
4) Phosphatidate phosphatase
Biochemistry Answer: 4
The enzyme phosphatidate phosphatase converts phosphatidic acid to diacylglycerol during synthesis of triacylglycerides.
The function of adipose tissue is the storage of fatty acids as triacylglycerols in times of plenty and the release of fatty acids during times of fasting or starvation.
Fatty acids taken in by adipocytes are stored by esterification to glycerol-3-phosphate. Glycerol-3-phosphate is derived almost entirely from the glycolytic intermediate dihydroxyacetone phosphate through the action of glycerol-3-phosphate dehydrogenase. Glycolytic enzymes are active in adipocytes during triglyceride synthesis, but those of glycogen degradation (low levels in adipocytes) and gluconeogenesis (ie, glucose-6-phosphatase) are not.
Glycerol kinase is not present to any great extent in adipocytes, so that glycerol freed during lipolysis is not used to reesterify the fatty acids being released.
The enzyme triacylglyceride lipase is turned on by phosphorylation by a cyclic AMP-dependent protein kinase following epinephrine stimulation.
All of the following statements are true for the acetylcholinesterase receptor
EXCEPT that it
1). opens an ion channel.
2). binds to succinylcholine.
3). undergoes irreversible conformational changes when exposed to carbamates
4). is inactivated in myasthenia gravis
Biochemistry
Answer: 2
Acetylcholinesterase receptor opens an ion channel, undergoes irreversible conformational changes when exposed to carbamates , it is inactivated in myasthenia gravis
Which of the following is a common dietary saturated fatty acid?
1. Oleic acid
2. Stearic acid
3. Linolenic acid
4. Arachidonic acid
Biochemistry
Answer: 4
Saturated fatty acids are a type of fat that has a chemical structure with a
single bond between each carbon atom in the fatty acid chain and no double
bonds. These types of fats are typically solid at room temperature. Out of the
given options, stearic acid (C18:0) is the only saturated fatty acid. The others
are:
1. Oleic acid (C18:1) is a monounsaturated fatty acid, which means it has one
double bond. It is commonly found in olive oil, canola oil, and avocados.
2. Linolenic acid (C18:3) is a polyunsaturated fatty acid, specifically an
omega-3 fatty acid, with three double bonds. It is found in plant sources like
flaxseeds, chia seeds, and walnuts.
3. Arachidonic acid (C20:4) is also a polyunsaturated fatty acid, an omega-6
fatty acid with four double bonds. It is found in animal fats, such as meat, and
in smaller amounts in some plant oils like sunflower oil and peanut oil.
Stearic acid, on the other hand, is a common saturated fatty acid found in
various animal fats and certain vegetable oils like coconut oil, palm kernel
oil, and cocoa butter. It is known for its role in the structure of cell
membranes and as a precursor for the biosynthesis of cholesterol in the body.
While it is important to consume fatty acids for good health, excessive
consumption of saturated fatty acids has been associated with higher levels of
LDL (low-density lipoprotein) cholesterol, which is often referred to as "bad"
cholesterol, and an increased risk of heart disease. However, it is important to
maintain a balanced diet that includes both saturated and unsaturated fatty
acids in moderation.
The principal role of Vitamin E in the prevention of oxidative damage is to
1. oxidize metals to their less reactive state.
2. potentiate the action of superoxide dismutase.
3. reduce Vitamin C to its active oxidation state.
4. terminate free radical chain reactions in lipid bilayers.
Biochemistry
Answer: 2
The principal role of Vitamin E in the prevention of oxidative damage is to potentiate the action of superoxide dismutase