MDS PREP
A patient with a history of alcohol abuse presents with jaundice, hepatosplenomegaly, and thrombocytopenia. The most likely diagnosis is:
1) Alcoholic hepatitis
2) Cirrhosis
3) Pancreatitis
4) Hepatic encephalopathy
The combination of jaundice, hepatosplenomegaly, and thrombocytopenia suggests that the patient has developed cirrhosis of the liver due to chronic alcohol abuse.
Spironolactone is most useful in
1) Zollinger-Ellison syndrome
2) Conn"s syndrome
3) Cushing syndrome
4) Acromegaly
General Medicine
Answer: 2
Spironolactone is a potassium-sparing diuretic often employed in the treatment of Conn's syndrome (primary hyperaldosteronism) to counteract excess aldosterone's effects.
Which of the following is a hallmark of alcoholic cirrhosis?
1) Massive hepatic necrosis
2) Fatty infiltration of hepatocytes
3) Extensive scar tissue and regenerative nodules
4) Inflammatory cell infiltration
Alcoholic cirrhosis is characterized by the presence of extensive scar tissue (fibrosis) and regenerative nodules within the liver. This results from chronic alcohol-induced damage to hepatocytes and the subsequent wound healing response.
When prescribing for a patient of renal failure, the elimination of drug from the kidney in the case of renal impairment all the following are correct except
1) Creatinine clearance is taken as guide
2) The normal main dose is given if the drug is being metabolized
3) The time to reach to steady state plasma concentration is the same as in patients with normal renal function
4) None of the above
General Medicine
Answer: 3
In renal impairment, the time to reach steady-state plasma concentration generally differs from that in patients with normal renal function due to altered clearance; hence, statement 3 is incorrect.
What is the primary source of vitamin D3 in humans?
1) Diet
2) Skin synthesis from sunlight
3) Intestinal bacteria
4) Supplementation
The precursor of vitamin D3, 7-dehydrocholesterol, is present in the keratinocytes of the skin's stratum corneum. Upon exposure to UV light, it is converted into cholecalciferol (vitamin D3).
In Henoch-Schonlien purpura there is all except
1) Abdominal pain with proteinuria
2) Acute arthritis
3) Rectal bleeding
4) More common in adults
General Medicine
Answer: 4
Henoch-Schonlein purpura (HSP) is a small-vessel vasculitis that is more common in children than in adults. It is characterized by symptoms such as abdominal pain, arthritis, and purpura (skin rash). The other options are typical manifestations of HSP.
What is the role of angiotensinogen in blood pressure regulation?
1) It is a precursor to angiotensin II, which is a potent vasoconstrictor and stimulant of aldosterone release.
2) It is a precursor to angiotensin I, which has no direct role in blood pressure regulation.
3) It acts as a co-factor in the production of bradykinin, a vasodilator.
4) It is a potent inhibitor of the renin-angiotensin system.
Angiotensinogen is converted to angiotensin II by the action of renin and angiotensin-converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone from the adrenal cortex, leading to sodium and water retention and an increase in blood pressure.
Which of the following is NOT a characteristic of ground-glass hepatocytes seen in HBV infection?
1) Spheres and tubules of HBsAg in the cytoplasm
2) Finely granular cytoplasm
3) Nuclear atypia
4) Preservation of the cell outline
Ground-glass hepatocytes are a hallmark of HBV infection and are characterized by spheres and tubules of HBsAg in the cytoplasm, resulting in a finely granular appearance. However, these cells typically show no significant nuclear atypia.