MDS PREP
Paroxymal noctural hemoglobinuria is due to -
1) Acquired red cell defect
2) Congential red cell defect
3) Auto immune defect
4) Lead poisoning
General Pathology
Answer: 1
Paroxysmal nocturnal hemoglobinuria is due to an acquired red cell defect, specifically a defect in the cell membrane that makes red blood cells susceptible to lysis.
The first vascular reaction In Inflammation is:
1. Vasoconstriction
2.
Vasodilation
3. Increased vascular permeability
4. Marginisation or pavementing
Pathology Answer: 2
The first vascular reaction in inflammation is Vasodilation.
Explanation:
Inflammation is the body's protective response to tissue injury or infection. It
is characterized by the classical signs of redness (rubor), heat (calor),
swelling (tumor), pain (dolor), and loss of function (functio laesa). The
initial vascular changes in the inflammatory process include:
1. Vasoconstriction: This is a temporary response that occurs immediately after
injury to minimize blood loss. However, it is quickly followed by the more
significant and prolonged phase of vasodilation.
2. Vasodilation: This is the first major vascular reaction in the inflammatory
response. Vasodilation occurs due to the release of substances such as
histamine, bradykinins, and prostaglandins from the damaged tissue cells and
mast cells. These substances are known as vasodilators and they cause the smooth
muscles surrounding the blood vessels to relax, leading to an increase in the
diameter of the blood vessels. This results in increased blood flow to the
injured area, which is essential for delivering white blood cells, nutrients,
and oxygen to the site of inflammation. The increased blood flow is what causes
the characteristic redness and heat of an inflamed area.
3. Increased vascular permeability: Although it is not the first vascular
reaction, increased vascular permeability is a critical component of the
inflammatory process. After vasodilation, the endothelial cells that line the
blood vessels become more permeable, allowing plasma and proteins to leak out of
the vessels into the surrounding tissue. This leads to the formation of an
exudate, which is the accumulation of fluid and proteins that makes up the
swelling (edema) seen in inflammation.
4. Marginisation or Pavementing: This is the process where neutrophils (a type
of white blood cell) move along the walls of blood vessels towards the site of
inflammation. It occurs later in the inflammatory response after the initial
vasodilation and increased vascular permeability. These cells then migrate
through the vessel walls into the tissue to combat pathogens and debris.
The maximum permissible dose of radiation to the operator of an X-ray machine is
1. 0.05 rem per year
2. 0.5 rem per year
3. 5.0 rem per year
4. 50 rem per year
Oral Pathology
Answer: 3
The maximum permissible dose of radiation to the operator of an X-ray machine is 5.0 rem per year.
A 23-year-old female presented with jaundice and pallor for 2 months. Her peripheral blood smear shows the presence of spherocytes. The most relevant investigation to arrive at a diagnosis is -
1) Reticulocyte count
2) Osmotic fragility test
3) Coombs test
4) Tests for PNH
General Pathology
Answer: 3
The osmotic fragility test is the most relevant investigation for diagnosing hereditary spherocytosis, as it assesses the red blood cells' ability to withstand osmotic stress.
Patient giving history of thrombocytopenic purpura reports for extraction. What could be the most common postoperative complication?
1. Oedema
2. Haemorrhage
3. Infection spreading through tissue spaces
4. Dry socket
Oral Pathology
Answer: 2
The most common postoperative complication in thrombocytopenic purpura is hemorrhage.
The common feature of cherubusm, hyperparathyroidism and aneurysmal bone cyst is
1. All affect soft tissues only
2. All contain multinucleated giant cells histologically
3. All are of pituitary origin
4. All require aggressive therapy
Oral Pathology
Answer: 2
All these conditions contain multinucleated giant cells histologically.
The X-rays which are mostly likely to be absorbed by the tissues and produce an injury
1. X-rays of long wavelength
2. X-rays of short wavelength
3. Filtered X-rays
4. Central rays
Oral Pathology
Answer: 1
X-rays of long wavelength are more likely to be absorbed by tissues and cause injury.
The residual biologic damage tha remains following an exposure to radiation is called
1. Direct effect
2. Indirect effect
3. Cumulative effect
4. Tolerance
Oral Pathology
Answer: 3
The residual biological damage that remains following exposure to radiation is called cumulative effect.