MDS PREP
What is the most common site of venous thrombosis in patients with cancer?
1) Superficial veins
2) Cerebral sinuses
3) Deep veins of the lower extremities
4) Hepatic veins
The most common site of venous thrombosis in patients with cancer is the deep veins of the lower extremities, often referred to as deep vein thrombosis (DVT). This is due to a combination of factors such as immobility, cancer-induced hypercoagulability, and damage to the vessels from tumor infiltration or surgery.
In the context of antitubercular therapy, which of the following is true about the metabolism of isoniazid and streptomycin?
(1) Both are metabolized in the liver
(2) Both are metabolized in the kidneys
(3) Isoniazid is metabolized in the liver, while streptomycin is metabolized in the kidneys
(4) Isoniazid is metabolized in the kidneys, while streptomycin is metabolized in the liver
Isoniazid is metabolized by the liver, while streptomycin is metabolized by the kidneys. This is important to consider when administering these drugs, especially in patients with hepatic or renal impairment.
What is the typical age range for increased risk of coronary heart disease in women?
1) ? 45 years
2) ? 55 years
3) ? 65 years
4) ? 75 years
For women, the increased risk of coronary heart disease typically starts at the age of 55 years.
What is the primary treatment for a pneumothorax?
(1) Inhalation of oxygen
(2) Chest tube placement
(3) Pleural fluid drainage
(4) Anti-inflammatory medication
The definitive treatment for a pneumothorax is the insertion of a chest tube, which allows the evacuation of air or gas from the pleural space and the re-expansion of the lung. This is crucial for alleviating the symptoms and preventing the condition from progressing to a tension pneumothorax, which can be life-threatening. Other treatments may include oxygen therapy and pain management.
A patient with severe nausea and vomiting is prescribed metoclopramide. What is the primary mechanism of action of metoclopramide?
(1) Antihistaminic action
(2) Dopamine antagonism in the CNS
(3) Muscarinic receptor antagonism
(4) 5-HT3 receptor antagonism
Metoclopramide acts primarily as a dopamine D2 receptor antagonist in the chemoreceptive trigger zone in the brain and in the gastrointestinal tract, which helps to reduce nausea and vomiting by decreasing gastric emptying and increasing gastric tone.
What is the target INR range for a patient on warfarin therapy to undergo minor oral surgery?
(1) Less than 2
(2) 2-3
(3) 3-4
(4) Less than 1.5
For a patient on warfarin therapy, the target INR (International Normalized Ratio) for undergoing minor oral surgery is typically 2-3. This range provides adequate thromboprophylaxis while minimizing the risk of excessive bleeding. However, the decision to proceed with surgery should be made on a case-by-case basis, considering the patient's overall health and surgical risks.
A patient with severe bronchospasm secondary to an asthma attack is administered a beta2 agonist. What is the primary mechanism of action of beta2 agonists?
(1) Stimulation of beta2 receptors in the heart
(2) Relaxation of bronchial smooth muscles
(3) Constriction of bronchial blood vessels
(4) Stimulation of mucus production
Beta2 agonists, such as albuterol, work by binding to beta2 receptors on the smooth muscles surrounding the airways, leading to relaxation of these muscles and bronchodilation, which helps alleviate the bronchospasm characteristic of an asthma attack.
What condition is NOT associated with osteoporosis?
1) Hypogonadism
2) Hyperthyroidism
3) Fluorosis
4) Hyperparathyroidism
Fluorosis is associated with osteosclerosis, not osteoporosis. It leads to increased bone density due to excessive deposition of fluoride.