MDS PREP
A 55-year-old male with a history of alcoholism presents with a chronic non-healing ulcer on his lower leg. The ulcer has a necrotic center surrounded by erythematous tissue. Which of the following is the most likely diagnosis?
1) Arterial ulcer
2) Venous stasis ulcer
3) Pressure ulcer
4) Neuropathic ulcer
The chronic non-healing nature of the ulcer and its location on the lower leg in an individual with a history of alcoholism are more consistent with a neuropathic ulcer. Neuropathy due to chronic alcohol use can lead to loss of protective sensation and poor blood supply, resulting in these types of ulcers.
What is the primary target of the immune response in Celiac disease?
1) Glia cells in the intestinal mucosa
2) Gluten proteins
3) Enterocytes in the intestinal villi
4) Pancreatic cells
Celiac disease is an autoimmune response to gluten proteins found in wheat, barley, rye, and possibly other grains, which leads to inflammation and damage in the small intestine.
What is the most common cause of death in patients with anaphylactic shock?
1) Respiratory failure due to bronchoconstriction
2) Cardiac arrest due to arrhythmias
3) Seizures
4) Stroke
The most common cause of death in anaphylactic shock is respiratory failure resulting from bronchoconstriction and laryngeal edema. Immediate airway management and bronchodilation are critical in the treatment of anaphylaxis.
What is the typical age of onset for children with growth hormone deficiency due to hypopituitarism?
1) At birth
2) During infancy
3) At the onset of puberty
4) Variable, but often in childhood
Growth hormone deficiency due to hypopituitarism can manifest at different ages depending on the underlying cause. It is often recognized in childhood when growth patterns are monitored regularly.
A 50-year-old male with a history of type 2 diabetes mellitus presents with sudden onset of severe, painful, and reddened skin on the dorsum of his foot. His blood glucose is 350 mg/dL. Which of the following is the most likely diagnosis?
1) Cellulitis
2) Diabetic neuropathic ulcer
3) Pyoderma gangrenosum
4) Erythema multiforme
The sudden onset of pain, redness, and swelling of the skin, particularly in a patient with poorly controlled diabetes, suggests a bacterial infection such as cellulitis.
Which of the following is NOT a type of E. coli associated with diarrheal disease?
1) Enterotoxigenic E. coli (ETEC)
2) Enteropathogenic E. coli (EPEC)
3) Enterohemorrhagic E. coli (EHEC)
4) Enteroaggregative E. coli (EAEC)
ETEC, EIEC, and EAEC are all types of E. coli that can cause diarrheal disease through various mechanisms. EPEC is typically associated with gastrointestinal illness, particularly in children, but does not typically cause the severe forms of diarrhea seen with ETEC or EHEC.
Pulmonary surfactant is
1) Lecithin
2) Dipalmitoyl phosphatidyl choline
3) Dipalmitoyl phosphatidyl serine
4) Sphingosine
General Medicine
Answer: 1
Pulmonary surfactant is lecithin
What is the major effector of cell injury in alcoholic hepatitis?
1) Tumor Necrosis Factor (TNF)
2) Interferon gamma (IFN-?)
3) Interleukin-10 (IL-10)
4) Interleukin-4 (IL-4)
TNF is considered the main effector of injury in alcoholic hepatitis. It is produced by activated macrophages, particularly Kupffer cells, and plays a critical role in the initiation and perpetuation of inflammation and necrosis in the liver.