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NEET MDS Shorts

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Pharmacology

Cephalosporins with antipseudomonal action:
Cefoperazone Ceftazidime

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Biochemistry

Vitamin B12 participates in two reactions in the body-conversion of homocysteine to methionine and conversion ofmethylmalonyl-CoA to succinyl-CoA.

Methylmalonyl-CoA is produced via various amino acid degradation pathways, and from oddcarbon chain fatty acid oxidation. In the absence of B12, succinyl-CoA would only be produced as an intermediate of the TCA cycle, and if it were removed from the cycle for heme synthesis, energy production may suffer.

Glycine is usually obtained from the diet, although in a B12 deficiency a functional folate deficiency may also develop, leading to an inhibition of serine hydroxymethyltransferase, the enzyme that converts serine to glycine, and requires free tetrahydrofolate.

Succinyl-CoA and glycine are the precursors for heme synthesis. A B12 deficiency would not inhibit the production of acetyl-CoA, succinate, or alanine. 

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Prosthodontics

A middle-aged patient gives a history of previous upper dentures remade many times as they are becoming tight within one year. You would suspect osteitis deformans.

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Oral Surgery

A tracheostomy is a surgical procedure that involves creating an opening in the trachea (windpipe) to facilitate breathing. The preferred site for making the incision during a tracheostomy is the cricothyroid ligament, which is located between the cricoid and thyroid cartilages.

  • Cricothyroid ligament: This ligament is relatively superficial and provides a safe access point to the airway, especially in emergency situations. It is often chosen for emergency tracheostomy because it is easier to locate and access quickly.


46754
NEETMDS

Ludwig's angina is a serious, potentially life-threatening infection of the floor of the mouth, typically polymicrobial in nature. The most common causative agents are bacteria that are part of the normal oral flora, primarily streptococci (both aerobic and anaerobic) and anaerobes, especially Bacteroides and Fusobacterium species. Anaerobic streptococci are frequently isolated from these infections, making them a primary agent.

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Medicine

Diarrhea causes a loss of bicarbonate HCO3-, which leads to a normal anion gap metabolic acidosis. 

The body compensates for the loss of the negative bicarbonate ions by retaining chloride ions Cl- to maintain electrical neutrality, resulting in hyperchloremic acidosis. Therefore, the anion gap,  remains within the normal range.

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NEETMDS

Secondary prevention involves early detection and prompt treatment to halt the disease process, such as a pulpotomy to prevent further progression.

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General Microbiology

ELISA: While ELISA (Enzyme-Linked Immunosorbent Assay) can be used to detect antibodies to the tuberculosis bacterium, it is not a direct method for diagnosing active TB infection. Direct methods include smear examination, culture, and nucleic acid technology, which detect the actual presence of the bacteria in the patient sample.

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Pedodontics

Prophy jet utilizes water with air powder of sodium bicarbonate.

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Physiology

Type I fibers are also called slow-twitch fibers due to their high myoglobin content, which supports aerobic metabolism and allows for sustained contractions over time.

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