57796

1. It is associated with platelet-specific autoantibodies: This statement is true. ITP is characterized by the presence of autoantibodies that specifically target and destroy platelets, leading to thrombocytopenia (low platelet count).

2. It causes a prolonged bleeding time: This statement is true. In ITP, the low platelet count results in a prolonged bleeding time, as there are fewer platelets available to form a clot.

3. It is often controllable by immunosuppressive treatment: This statement is true. ITP can often be managed with immunosuppressive therapies, such as corticosteroids, intravenous immunoglobulin (IVIG), or other immunosuppressive agents, to help increase platelet counts.

4. It causes more prolonged hemorrhage than hemophilia: This statement is not true. While both ITP and hemophilia can lead to bleeding, the mechanisms are different. Hemophilia is a clotting factor deficiency, which can lead to more severe and prolonged bleeding episodes, especially after trauma or surgery. In contrast, ITP primarily affects the number of platelets rather than the clotting factors. Therefore, the bleeding in hemophilia can be more severe and prolonged compared to that in ITP.

95433

Keratosis follicularis (Dariers disease) is characterized by defective adhesion between epithelial cells due to mutations in ATP2A2 gene affecting calcium regulation and cell adhesion. This leads to acantholysis and characteristic histologic findings. White sponge nevus involves keratin mutations, and pachyonychia congenita affects nail and skin keratinization, but keratosis follicularis specifically shows defective intercellular adhesion.

79656

Quantity of the X-ray beam is governed by mAs (milliampere-seconds).

87912

Using "B" film, exposure of 1 R will be reduced to 1/4 R when "D" film is used.

15548

Coronal dentin dysplasia is a genetic condition that affects the development of dentin, leading to abnormal pulp chamber morphology. The "thistle-tube" appearance refers to the shape of the pulp chamber, which resembles a thistle tube due to the constricted and elongated form of the pulp space. This condition is characterized by a normal crown appearance but with significant alterations in the pulp chamber and root canal system, making it distinct from other dental dysplasias.

56722

X-rays were discovered in November 1895.

18405

Tetracycline stains appear as yellow and brown stains in both enamel and dentin.

59166

Darier’s disease is associated with a deficiency of Vitamin A involving mucosa and epithelium.

56420

The gingiva is taken as the confirmation biopsy site for amyloidosis.

63084

Hyaluronidase, sometimes referred to as the "spreading factor", is an enzyme produced by certain microorganisms (e.g., Streptococcus pyogenes and some Clostridium species) that degrades hyaluronic acid, a key component of the connective tissue matrix.