Study Notes

Drug-Receptor Interactions Drug Receptor:  any functional macromolecule in a cell to which a drug binds to produce its effects.  at receptors, drugs mimic or block the action of the body's own regulatory molecules.   Receptors and Selectivity of Drug Action : If a drug interacts with only one kind of receptor, and if that receptor regulates just a few processes, then the effects of the drug will be limited. Even though a drug is selective…

Uses of NSAIDs NSAIDs are usually indicated for the treatment of acute or chronic conditions where pain and inflammation are present. Research continues into their potential for prevention of colorectal cancer, and treatment of other conditions, such as cancer and cardiovascular disease. NSAIDs are generally indicated for the symptomatic relief of the following conditions. rheumatoid arthritis, osteoarthritis, inflammatory arthropathies (e.g. ankylosing spo…

Osteomyelitis This refers to inflammation of the bone and related marrow cavity almost always due to infection. Osteomyelitis can be acute or a chronic. The most common etiologic agents are pyogenic bacteria and Mycobacterium tuberculosis. Pyogenic Osteomyelitis The offending organisms reach the bone by one of three routes: 1. Hematogenous dissemination (most common) 2. Extension from a nearby infection (in adjacent joint or soft tissue) 3. Traumatic impla…

Neutralization Test These are basically of two types: •    Toxin neutralization •    Virus neutralization In toxin neutralization homologous anti-bodies prevent the biological effect of toxin as observed in vivo in experimental animals (e.g. detection of toxin of Clostridia and Corynebacterium diphthenae) or by in vitro method (e.g. Nagler’s method). In virus neutralization test various methods are availab…