NEET MDS Lessons
Anatomy
Histology
Histology is the study of tissues.
A tissue is a group of cells with similar structure and function plus the extracellular substances located between the cells.
There are four basic types of tissues:
- Epitheliums
- Connective tissue
- Muscle tissue
- Nervous tissue
Skeletal Muscle: 1-40 cm long fibres, 10- 60 µm thick, according to myoglobin content there are:
Red fibres: lots of myoglobin, many mitochondriam slow twitching - tire slowly
White fibres: less myoglobin, less mitochondria, fast twitching - tire quickly
Intermediate fibres:
mixture of 2 above
Most muscles have all three - in varying ratios
Structure of skeletal muscle:
Light Microscopy: Many nuclei - 35/mm, Nuclei are oval - situated peripheral, Dark and light bands
Electron Microscopy: Two types of myofilaments
Actin
- 5,6 nm
3 components:
-actin monomers,
-tropomyosin - 7 actin molecules long
- troponin
actin monomers form 2 threats that spiral
- tropomyosin - lie in the groove of the spiral
- troponin - attach every 40 nm
- one end attach to the Z line
- other end goes to the middle of the sarcomere
- Z line consists of á actinin
Myosin:
- 15 nm
- 1,6 µm long
- The molecule has a head and a tail
- tails are parallel
- heads project in a spiral
- in the middle is a thickening
- thin threats bind the myosin at thickening (M line)
Contraction:
A - band stays the same, I - band, H - bands become narrower
Myosin heads ratchet on the actin molecule
Sarcolemma: 9 nm thick, invaginate to form T-tubule,
myofibrils - attach to the sarcolemma
Sarcoplasmic Reticulum:
specialized smooth EPR, Consists of T-tubules, terminal sisternae and sarcotubules
It is speculated that there are gap junctions between the T-tubule and terminal sisterna
An impulse is carried into the fiber by the T-tubule from where it goes to the rest of the sarcoplasmic reticulum
Connective tissue coverings of the muscle
Endomycium around fibres, perimycium around bundles and epimycium around the whole muscle
Blood vessels and nerves in CT
CT goes over into tendon or aponeurosis which attaches to the periosteum
Nerves:
The axon of a motor neuron branches and ends in motor end plates on the fiber
Specialized striated fibres called spindles (stretch receptors) form sensory receptors in muscles telling the brain how far the muscle has stretched
The Submandibular Glands
- Each of these U-shaped salivary glands is about the size of a thumb and lies along the body of the mandible.
- It is partly superior and partly inferior to the posterior 1/2 of the base of the mandible.
- It is partly superficial and partly deep to the mylohyoid muscle.
- The submandibular duct arises from the portion of the gland that lies between the mylohyoid and hyoglossus muscle.
- The duct passes deep and then superficial to the lingual nerve.
- It opens by one to three orifices on a small sublingual papilla beside the lingual frenulum.
- The submandibular gland is supplied by parasympathetic, secretomotor fibres from the submandibular ganglion (preganglionic fibres from the chorda tympani via the lingual nerve).
Nerve Supply of the Muscles of the Orbit (pp. 715-6)
- Three cranial nerves supply the muscles of the eyeball; the oculomotor (CN III), trochlear (CN IV) and abducent (CN IV) nerves.
- All three enter the orbit via the superior orbital fissure.
- The trochlear nerve supplies the superior oblique muscle.
- The abducent nerve supplies the lateral rectus muscle.
- The oculomotor nerve supplies everything else.
- A mnemonic that is used is this formula for this strange sulfate: SO4(LR6)3
The Medial Wall of the Orbit
- This wall is paper-thin and is formed by the orbital lamina or lamina papyracea of the ethmoid bone, along with contributions from the frontal, lacrimal, and sphenoid bones (L. papyraceus, "made of papyrus" or parchment paper).
- There is a vertical lacrimal groove in the medial wall, which is formed anteriorly by the maxilla and posteriorly by the lacrimal bone.
- It forms a fossa for the lacrimal sac and the adjacent part of the nasolacrimal duct.
- Along the suture between the ethmoid and frontal bones are two small foramina; the anterior and posterior ethmoidal foramina.
- These transmit nerves and vessels of the same name.
The Tongue
- The tongue (L. lingua; G. glossa) is a highly mobile muscular organ that can vary greatly in shape.
- It consists of three parts, a root, body, and tip.
- The tongue is concerned with mastication, taste, deglutition (swallowing), articulation (speech), and oral cleansing.
- Its main functions are squeezing food into the pharynx when swallowing, and forming words during speech.
Internal Muscles of the Pharynx
- The internal, chiefly longitudinal muscular layer, consists of 3 muscles: stylopharyngeus, palatopharyngeus, and salpingopharyngeus.
- They all elevate the larynx and pharynx during swallowing and speaking.
The Stylopharyngeus Muscle
- This is a long, thin, conical muscles that descends inferiorly between the external and internal carotid arteries.
- It enters the wall of the pharynx between the superior and middle constrictor muscles.
- Origin: styloid process of temporal bone.
- Insertion: posterior and superior borders of thyroid cartilage with palatopharyngeus muscle.
- Innervation: glossopharyngeal nerve (CN IX).
- It elevates the pharynx and larynx and expands the sides of the pharynx, thereby aiding in pulling the pharyngeal wall over a bolus of food.
The Palatopharyngeus Muscle
- This is a thin muscle and the overlying mucosa form the palatopharyngeal arch.
The Salpingopharyngeus Muscle
- This is a slender muscle that descends in the lateral wall of the pharynx.
- The over lying mucous membrane forms the salpingopharyngeal fold.
- Origin: cartilaginous part of the auditory tube.
- Insertion: blends with palatopharyngeus muscle.
- Innervation: through the pharyngeal plexus.
- It elevates the pharynx and larynx and opens the pharyngeal orifice of the auditory tube during swallowing.