Structure

There are 3 pairs

 The functional unit is the adenomere.

The adenomere consists of secreting units and an intercalated duct, which opens, in a striated duct.

An secreting unit can be:

- mucous secreting

- serous secreting

THE SECRETING UNIT

THE CELLS

Serous cells

(seromucus cells=secrete also polysaccharides), They have all the features of a cell specialized for the synthesis, storage, and secretion of protein
 Pyramidal, Nuclei are rounded and more centrally placed,  In the basal 1/3 there is an accumulation of Granular EPR,  In the apex there are proteinaceous secretory granules,  Cells stain well with H & E (red),  Between cells are intercellular secretory capillaries

Rough endoplasmic reticulum (ribosomal sites-->cisternae)
Prominent Golgi-->carbohydrate moieties are added
Secretory granules-->exocytosis
The secretory process is continuous but cyclic
There are complex foldings of cytoplasmic membrane
The junctional complex consists of: 1) tight junctions (zonula occludens)-->fusion of outer cell layer, 2) intermediate junction (zonula adherens)-->intercellular communication, 3)desmosomes-->firm adhesion

Mucus cells

Pyramidal,  Nuclei are flattened and near the base,  Have big clear secretory granules

Cells do not stain well with H & E (white)

Production, storage, and secretion of proteinaceous material; smaller enzymatic component
-more carbohydrates-->mucins=more prominent Golgi
-less prominent (conspicuous) rough endoplasmic reticulum, mitochondria
-less interdigitations
 

Myoepithelial cells

Star-shaped, Centrally located nucleus, Long cytoplasmic arms - bound to the secretory cells by desmosomes, Have fibrils like smooth muscle, Squeeze the secretory cell

One, two or even three myoepithelial cells in each salivary and piece body, four to eight processes
Desmosomes between myoepithelial cells and secretory cells myofilaments frequently aggregated to form dark bodies along the course of the process. The myoepithelial cells of the intercalated ducts are more spindled-shaped and fewer processes
Ultrastructure very similar to that of smooth muscle cells (myofilaments, desmosomal attachments)
 

Functions of myoepithelial cells
-Support secretory cells
-Contract and widen the diameter of the intercalated ducts
-Contraction may aid in the rupture of acinar cells of epithelial origin

Ductal system

Three classes of ducts:
Intercalated ducts

They have small diameter; lined by small cuboidal cells; nucleus located in the center. They have a well-developed RER, Golgi apparatus, occasionally secretory granules, few microvilli. Myoepithelial cells are also present. Intercalated ducts are prominent in salivary glands having a watery secretion (parotid).
Striated ducts

They have columnar cells, a centrally located nucleus, eosinophilic cytoplasm. Prominenty striations that refer to indentations of the cytoplasmic membrane with many mitochondria present between the folds. Some RER and some Golgi. The cells have short microvilli.
The cells of the striated ducts modify the secretion (hypotonic solution=low sodium and chloride and high potassium). There is also presence of few basal cells.
Terminal excretory ducts

Near the striated ducts they have the same histology as the striated ducts. As the duct reaches the oral mucosa the lining becomes stratified. In the terminal ducts one can find goblet cells, basal cells, clear cells. The terminal ducts alter the electrolyte concentration and add mucoid substance.

Connective tissue
Presence of fibroblasts, inflammatory cells, mast cells, adipose cells
Extracellular matrix (glycoproteins and proteoglycans)
Collagen and oxytalan fibers
 

 Nerve supply
The innervation of salivary glands is very complicated. There is no direct inhibitory innervation. There are parasympathetic and sympathetic impulses, the parasympathetic are more prevalent.
The parasympathetic impulses may occur in isolation, evoke most of the fluid to be excreted, cause exocytosis, induce contraction of myoepithelial cells (sympathetic too) and cause vasodialtion. There are two types of innervation: epilemmal and hypolemmal. There are beta-adrenergic receptors that induce protein secretion and L-adrenergic and cholinergic receptors that induce water and electrolyte secretion.

Hormones can influence the function of the salivary glands. They modify the salivary content but cannot initiate salivary flow.

Age changes

Fibrosis and fatty degenerative changes
Presence of oncocytes (eosinophilic cells containing many mitochondria)

Clinical considerations

Role of drugs, systemic disorders, bacterial or viral infections, therapeutic radiation, obstruction, formation of plaque and calculus.

    - Rich capillary networks surround the adenomeres.

TOOTH MORPHOLOGY

Descriptive anatomy

• Median sagittal plane: the imaginary plane in the center that divides right from left.
• Median line: an imaginary line on that plane that bisects the dental arch at the center.
• Mesial: toward the center (median) line of the dental arch.
• Distal: away from the center (median) line of the dental arch.
• Occlusal plane: A plane formed by the cusps of the teeth. It is often curved, as in a cylinder. We will speak often of the occlusal surface of a tooth.
• Proximal: the surface of a tooth that is toward another tooth in the arch.
• Mesial surface: toward the midline.
• Distal surface: away from the midline.
• Facial: toward the cheeks or lips.
• Labial: facial surface of anterior teeth (toward the lips).
• Buccal: facial surfaceof anterior teeth (toward the cheeks).
• Lingual: toward the tongue.
• Occlusal: the biting surface; that surface that articulates with an antagonist tooth in an opposing arch.
• Incisal: cutting edge of anterior teeth.
• Apical: toward the apex, the tip of the root.

TYPES OF TEETH

The human permanent dentition is divided into four classes of teeth based on appearance and function or position.

Incisors, Canines, Premolars & Molars

SURFACES OF THE TEETH

Facial, Mesial, Distal, Lingual, and Incisal Surfaces

• The facial is the surface of a tooth that "faces" toward the lips or cheeks. When there is a requirement to be more specific, terms like labial and buccal are used. The labial is the surface of an anterior tooth that faces toward the lips. The buccal is the surface of a posterior tooth that faces toward the cheek.
• The mesial is the proximal surface closest to the midline of the arch. The distal is the opposite of mesial. The distal is the proximal surface oriented away from the midline of the arch.
• The lingual is the surface of an anterior or posterior tooth that faces toward the tongue. Incisal edges are narrow cutting edges found only in the anterior teeth (incisors). Incisors have one incisal edge
• Proximal Surfaces

A tooth has two proximal surfaces, one that is oriented toward the midline of the dental arch (mesial) and another that is oriented away from the midline of the arch (distal).

THE DECIDUOUS DENTITION

I. The Deciduous Dentition

-It is also known as the primary, baby, milk or lacteal dentition.

diphyodont, that is, with two sets of teeth. The term deciduous means literally 'to fall off.'

  There are twenty deciduous teeth that are classified into three classes. There are ten maxillary teeth and ten mandibular teeth. The dentition consists of incisors, canines and molars.