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Anatomy - NEETMDS- courses
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Anatomy

Classification

Epitheliums can be classified on appearance or on function

Classification based on appearance

- Simple - one layer of cells

- Pseudostratified - looks like more than one layer but is not

- Stratified - more than one layer of cells

Simple epitheliums

Simple squamous epithelium

 Cells are flat with bulging or flat nuclei.  Lines the insides of lung alveoli and certain ducts in the kidney

 Forms serous membranes called mesothelium that line cavities like: pericardial ,  peritoneal,  plural

 Lines blood vessels - known as endothelium

Simple cuboidal epithelium

It appears square in cross section,  Found in: - Ducts of salivary glands,  Follicles of the thyroid gland,  Pigment layer in the eye,  Collecting ducts of the kidney, In the middle ear is ciliated type.

Simple columnar

  • Lines the gastrointestinal tract from the stomach to the anal canal,  Some columnar cells have a  secretory function – stomach, peg cells in the oviduct,  Some columnar cells have microvilli on their free border (striated border) – gall bladder, duodenum
  • Microvilli increase the surface area for absorption
  • Some columnar cells have cilia – oviduct, smaller bronchi
  • Cilia transport particles

Pseudostratified

Appears as stratified epithelium but all cells are in contact with the basement membrane.  Has a thick basement membrane. Different cell types make up this epithelium,  Cells that can be found in this type of epithelium are:

  • Columnar cells with cilia or microvilli.
  • Basal cells that do not reach the surface.
  • Goblet cells that secrete mucous.
  • Found in the trachea, epididymus, ductus deferens and female urethra

Stratified epithelium

Classified according to the shape of the surface cells

Stratified squamous epithelium

Has a basal layer that varies from cuboidal to columnar cells that divide to form new cells. Two types are found:

Keratinized:  Mostly forms a dry covering, The middle layers consists of cells that are forming- and filling up with keratin. The superficial cells form a tough non living layer of keratin,  Keratin is a type of protein,  The skin is of this type has  thick skin - found on the hand palms and soles of the feet,  thin skin - found on the rest of the body

Non-keratinized:  Top layer of cells are living cells with nuclei  Forms a wet covering,  The middle layers are polyhedral,  The surface layer consists of flat squamous cells

  • Is found in:  mouth,  oesophagus,  vagina

Stratified cuboidal epithelium

Found: - in the ducts of sweat glands

Stratified columnar epithelium

Found at the back of the eyelid (conjunctiva)

Transitional epithelium

- Sometimes the surface cells are squamous, sometimes cuboidal and sometimes columnar

- The superficial cells are called umbrella cells because they can open and close like umbrellas, when the epithelium stretch and shrink

- Umbrella cells can have 2 nuclei

- Found in the bladder and ureter

Stylohyoid Muscle

  • Origin: Posterior border of the styloid process of the temporal bone.
  • Insertion: Body of the hyoid bone at the junction with the greater horn.
  • Nerve Supply: Facial nerve (CN VII).
  • Arterial Supply: Muscular branches of the facial artery and muscular branches of the occipital artery.
  • Action: Elevates the hyoid bone and base of the tongue.

Hip

Constitutes the pelvic girdle
United with the vertebral column
Union of three parts that is marked by a cup shaped cavity (acetabulum) Ilium
•    Prominence of the hip
•    Superior border is the crest
•    Anterosuperior spine-projection at the anterior tip of the crest
•    Corresponding projections on the posterior part are the posterosuperior and posteroinferior iliac spines
•    Greater sciatic notch-located beneath the posterior part
•    Most is a smooth concavity (iliac fossa)
•    Posteriorly it is rough and articulates with the sacrum in the formation of the sacroiliac joint

Pubic bone

Anterior part of the innominate bone
Symphysis pubic-joining of the two pubic bones at the midline
Body and two rami 
•    Body forms one fifth of the acetabulum
•    Superior ramis extends from the body to the median plane: superior border forms the pubic crest
•    Inferior ramus extends downward and meets with the ischium
•    Pubic arch is formed by the inferior rami of both pubic hones

Ischium
    Forms the lower and back part of the innominate bone
    Body
•    Forms two fifths of the accrabulum
•    Ischial tuberosiry-supports the body in a sitting position
•    Ramus-passes upward to join the inferior ramus of rhe pubis; known as rhe obturator foramen

Pelvis

Fanned by the right and left hip bones, sacrum, and coccyx

Greater pelvis

o    Bounded by the ilia and lower lumbar vertebrae
o    Gives support to the abdominal viscera

Lesser pelvis

o    Brim of the pelvis corresponds to the sacral promontory
o    Inferior outlet is bounded by the tip of the coccyx, ischial tuberosities, and inferior rami of the pubic bones

Female pelvis

o    Shows adaptations related to functions as a birth canal Wide outlet
o    Angle of the pubic arch is obtuse

Male pelvis

o    Shows adaptations that contribute to power and speed
o    Heart-shaped outlet
o    Angle of the pubic arch is acute


Thigh

Femur-longest and strongest bone of the body
Proximal end has a rounded head that articulates with the acetabulum
Constricted portion-the neck
Greater and lesser trochanters
Slightly arched shaft; is concave posteriorly
o    Linea aspera-strengthened by this prominent ridge
o    Site of attachment for several muscles
Distal end has two condyles separated on the posterior side by the intercondyloid notch

Knee cap

Patella-sesamoid bone
Embedded in the tendon of the quadriceps muscle
Articulates with the femur


Leg

Tibia-medial bone
o    Proximal end has two condyles that articulate with the femur
o    Triangular shaft

    Anterior-shin
    Posterior-soleal line
    Distal-medial malleolus that articulates with the latus to form the ankle joint
Fibula-lateral bone
o    Articulates with the lateral condyle of the tibia but does not enter the knee joint
o    Distal end projects as the lateral malleolus


Ankle, foot, and toes

Adapted for supporting weight but similar in structure to the hand

Talus

o    Occupies the uppennost and central position in the tarsus
o    Distributes the body weight from the tibia above to the other tarsal bones
Calcaneus (heel)-Iocated beneath the talus
Navicular-located in front of the talus on the medial side; articulates with three cuneifonn bones distally
Cuboid-lies along the lateral border of the navicular bone

Metatarsals
o    First, second, and third p1etatarsals lie in front of the three cuneifonn bones
o    (2) Fourth and fifth metatarsals lie in front of the cuboid bone

Phalanges

o    Distal to the metatarsals
o    (2) Two in the great toe; three in each of the other four toes .

Longitudinal arches in the foot (2)

o    Lateral-fonned by the calcaneus, talus, cuboid, and fourth and fifth metatarsal bones
o    Medial-fonned by the calcaneus, talus, navicular, cuneifonn, and first, second, and third metatarsal bones

Transverse arches-formed by the tarsal and metatarsal bones

 

  • Cartilage model is covered with perichondrium that is converted to periosteum

  • Diaphysis-central shaft
  • Epiphysis-located at either end of the diaphysis
  • Growth in length of the bone is provided by the emetaphyseal plate located between the epiphyseal cartilage and the diaphysis
  • Blood capillaries and the mesenchymal cells infiltrate the spaces left by the destroyed chondrocytes

  • Osteoblasts are derived from the undifferentiated cells; form an osseous matrix in the cartilage
  • Bone appears at the site where there was cartilage

      Microscopic structure

  • Compact bone is found on the exterior of all bones; canceIlous bone is found in the interior
  • Surface of compact bone is covered by periosteum that is attached by Sharpey's fibers
  • Blood vessels enter the periosteum via Volkmann's canals and then enter the haversian canals that are formed by the canaliculi and lacunae
  •  

  • Marrow
    • FiIls spaces of spongy bone
    • Contains blood vessels and blood ceIls in various stages of development
    • Types
  • Red bone marrow
    • Formation of red blood ceIls (RBCs) and some white blood cells (WBCs) in this location
    • Predominate type of marrow in newborn
    • Found in spongy bone of adults (sternum, ribs, vertebrae, and proximal epiphyses of long bones)
  •  Yellow bone marrow
    • Fatty marrow
    • Generally replaces red bone marrow in the adult, except in areas mentioned above
  •  
  • Ossification is completed as the proximal epiphysis joins with the diaphysis between the twentieth and twenty-fifth year

Walls of the Tympanic Cavity or Middle Ear

  • This cavity is shaped like a narrow six-sided box that has convex medial and lateral walls.
  • It has the shape of the biconcave lens in cross-section (like a red blood cell).

 

The Roof or Tegmental Wall

  • This is formed by a thin plate of bone, called the tegmen tympani (L. tegmen, roof).
  • It separates the tympanic cavity from the dura on the floor of middle cranial fossa.
  • The tegmen tympani also covers the aditus ad antrum.

 

The Floor or Jugular Wall

  • This wall is thicker than the roof.
  • It separates the tympanic cavity from the superior bulb of the internal jugular vein. The internal jugular vein and the internal carotid artery diverge at the floor of the tympanic cavity.
  • The tympanic nerve, a branch of the glossopharyngeal nerve (CN IX), passes through an aperture in the floor of the tympanic cavity and its branches form the tympanic plexus.

The Lateral or Membranous Wall

  • This is formed almost entirely by the tympanic membrane.
  • Superiorly it is formed by the lateral bony wall of the epitympanic recess.
  • The handle of the malleus is incorporated in the tympanic membrane, and its head extends into the epitympanic recess.

The Medial or Labyrinthine Wall

  • This separates the middle ear from the membranous labyrinth (semicircular ducts and cochlear duct) encased in the bony labyrinth.
  • The medial wall of the tympanic cavity exhibits several important features.
  • Centrally, opposite the tympanic membrane, there is a rounded promontory (L. eminence) formed by the first turn of the cochlea.
  • The tympanic plexus of nerves, lying on the promontory, is formed by fibres of the facial and glossopharyngeal nerves.
  • The medial wall of the tympanic cavity also has two small apertures or windows.
  • The fenestra vestibuli (oval window) is closed by the base of the stapes, which is bound to its margins by an annular ligament.
  • Through this window, vibrations of the stapes are transmitted to the perilymph window within the bony labyrinth of the inner ear.
  • The fenestra cochleae (round window) is inferior to the fenestra vestibuli.
  • This is closed by a second tympanic membrane.

 

The Posterior or Mastoid Wall

  • This wall has several openings in it.
  • In its superior part is the aditus ad antrum (mastoid antrum), which leads posteriorly from the epitympanic recess to the mastoid cells.
  • Inferiorly is a pinpoint aperture on the apex of a tiny, hollow projection of bone, called the pyramidal eminence (pyramid).
  • This eminence contains the stapedius muscle.
  • Its aperture transmits the tendon of the stapedius, which enters the tympanic cavity and inserts into the stapes.
  • Lateral to the pyramid, there is an aperture through which the chorda tympani nerve, a branch of the facial nerve (CN VII), enters the tympanic cavity.

The Anterior Wall or Carotid Wall

  • This wall is a narrow as the medial and lateral walls converge anteriorly.
  • There are two openings in the anterior wall.
  • The superior opening communicates with a canal occupied by the tensor tympani muscle.
  • Its tendon inserts into the handle of the malleus and keeps the tympanic membrane tense.
  • Inferiorly, the tympanic cavity communicates with the nasopharynx through the auditory tube.

Nerves of the Palate

  • The sensory nerves of the palate, which are branches of the pterygopalatine ganglion, are the greater and lesser palatine nerves.
  • They accompany the arteries through the greater and lesser palatine foramina, respectively.
  • The greater palatine nerve supplies the gingivae, mucous membrane, and glands of the hard palate.
  • The lesser palatine nerve supplies the soft palate.
  • Another branch of the pterygopalatine ganglion, the nasopalatine nerve, emerges from the incisive foramen and supplies the mucous membrane of the anterior part of the hard palate.

Skeletal Muscle:  1-40 cm long fibres, 10- 60 µm thick, according to myoglobin content there are:

Red fibres: lots of myoglobin, many mitochondriam slow twitching - tire slowly

White fibres:  less myoglobin,  less mitochondria, fast twitching - tire quickly

Intermediate fibres:

mixture of 2 above

Most muscles have all three - in varying ratios

Structure of skeletal muscle:

Light Microscopy:  Many nuclei - 35/mm,  Nuclei are oval - situated peripheral,  Dark and light bands

Electron Microscopy: Two types of myofilaments

Actin

- 5,6 nm

 3 components:

 -actin monomers,  

 -tropomyosin - 7 actin molecules long

- troponin

 actin monomers form 2 threats that spiral

- tropomyosin - lie in the groove of the spiral

- troponin - attach every 40 nm

- one end attach to the Z line

- other end goes to the middle of the sarcomere

- Z line consists of á actinin

Myosin:

- 15 nm

- 1,6 µm long

- The molecule has a head and a tail

- tails are parallel

- heads project in a spiral

- in the middle is a thickening

- thin threats bind the myosin at thickening (M line)

Contraction:

A - band stays the same, I - band, H - bands become narrower

Myosin heads ratchet on the actin molecule

Sarcolemma: 9 nm thick,  invaginate to form T-tubule,

 myofibrils - attach to the sarcolemma

Sarcoplasmic Reticulum:

specialized smooth EPR,  Consists of T-tubules, terminal sisternae and sarcotubules

It is speculated that there are gap junctions between the T-tubule and terminal sisterna

An impulse is carried into the fiber by the T-tubule from where it goes to the rest of the sarcoplasmic reticulum

Connective tissue coverings of the muscle

Endomycium around fibres, perimycium around bundles and epimycium around the whole muscle

Blood vessels and nerves in CT

CT goes over into tendon or aponeurosis which attaches to the periosteum

Nerves:

The axon of a motor neuron branches and ends in motor end plates on the fiber

Specialized striated fibres called spindles (stretch receptors) form sensory receptors in muscles telling the brain how far the muscle has stretched

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