NEET MDS Lessons
Anatomy
Skeletal Muscle: 1-40 cm long fibres, 10- 60 µm thick, according to myoglobin content there are:
Red fibres: lots of myoglobin, many mitochondriam slow twitching - tire slowly
White fibres: less myoglobin, less mitochondria, fast twitching - tire quickly
Intermediate fibres:
mixture of 2 above
Most muscles have all three - in varying ratios
Structure of skeletal muscle:
Light Microscopy: Many nuclei - 35/mm, Nuclei are oval - situated peripheral, Dark and light bands
Electron Microscopy: Two types of myofilaments
Actin
- 5,6 nm
3 components:
-actin monomers,
-tropomyosin - 7 actin molecules long
- troponin
actin monomers form 2 threats that spiral
- tropomyosin - lie in the groove of the spiral
- troponin - attach every 40 nm
- one end attach to the Z line
- other end goes to the middle of the sarcomere
- Z line consists of á actinin
Myosin:
- 15 nm
- 1,6 µm long
- The molecule has a head and a tail
- tails are parallel
- heads project in a spiral
- in the middle is a thickening
- thin threats bind the myosin at thickening (M line)
Contraction:
A - band stays the same, I - band, H - bands become narrower
Myosin heads ratchet on the actin molecule
Sarcolemma: 9 nm thick, invaginate to form T-tubule,
myofibrils - attach to the sarcolemma
Sarcoplasmic Reticulum:
specialized smooth EPR, Consists of T-tubules, terminal sisternae and sarcotubules
It is speculated that there are gap junctions between the T-tubule and terminal sisterna
An impulse is carried into the fiber by the T-tubule from where it goes to the rest of the sarcoplasmic reticulum
Connective tissue coverings of the muscle
Endomycium around fibres, perimycium around bundles and epimycium around the whole muscle
Blood vessels and nerves in CT
CT goes over into tendon or aponeurosis which attaches to the periosteum
Nerves:
The axon of a motor neuron branches and ends in motor end plates on the fiber
Specialized striated fibres called spindles (stretch receptors) form sensory receptors in muscles telling the brain how far the muscle has stretched
The Layers of the Pharyngeal Wall
- The pharyngeal wall is composed of 5 layers. From internal to external, they are as follows.
- Mucous membrane: this lines the pharynx and is continuous with all chambers with which it communicates.
- Submucosa
- Pharyngobasilar fascia: this is a fibrous layer that is attached to the skull.
- Muscular layer: this is composed of inner longitudinal and outer circular parts.
- Buccopharyngeal fascia: this is a loose connective tissue layer.
- This fascia is continuous with the fascia covering the buccinator and pharyngeal muscle.
- It contains the pharyngeal plexus of nerves and veins.
- Long bones (e.g.. femur and humerus)
- Short bones (e.g.. wrist and ankle bones)
- Flat bones (e.g.. ribs)
- Irregular bones (e.g.. vertebrae)
Intrinsic Muscles of the Tongue
The Superior Longitudinal Muscle of the Tongue
- The muscle forms a thin layer deep to the mucous membrane on the dorsum of the tongue, running from its tip to its root.
- It arises from the submucosal fibrous layer and the lingual septum and inserts mainly into the mucous membrane.
- This muscle curls the tip and sides of the tongue superiorly, making the dorsum of the tongue concave.
The Inferior Longitudinal Muscle of the Tongue
- This muscle consists of a narrow band close to the inferior surface of the tongue.
- It extends from the tip to the root of the tongue.
- Some of its fibres attach to the hyoid bone.
- This muscle curls the tip of the tongue inferiorly, making the dorsum of the tongue convex.
The Transverse Muscle of the Tongue
- This muscle lies deep to the superior longitudinal muscle.
- It arises from the fibrous lingual septum and runs lateral to its right and left margins.
- Its fibres are inserted into the submucosal fibrous tissue.
- The transverse muscle narrows and increases the height of the tongue.
The Vertical Muscle of the Tongue
- This muscle runs inferolaterally from the dorsum of the tongue.
- It flattens and broadens the tongue.
- Acting with the transverse muscle, it increases the length of the tongue.
Hip
Constitutes the pelvic girdle
United with the vertebral column
Union of three parts that is marked by a cup shaped cavity (acetabulum) Ilium
• Prominence of the hip
• Superior border is the crest
• Anterosuperior spine-projection at the anterior tip of the crest
• Corresponding projections on the posterior part are the posterosuperior and posteroinferior iliac spines
• Greater sciatic notch-located beneath the posterior part
• Most is a smooth concavity (iliac fossa)
• Posteriorly it is rough and articulates with the sacrum in the formation of the sacroiliac joint
Pubic bone
Anterior part of the innominate bone
Symphysis pubic-joining of the two pubic bones at the midline
Body and two rami
• Body forms one fifth of the acetabulum
• Superior ramis extends from the body to the median plane: superior border forms the pubic crest
• Inferior ramus extends downward and meets with the ischium
• Pubic arch is formed by the inferior rami of both pubic hones
Ischium
Forms the lower and back part of the innominate bone
Body
• Forms two fifths of the accrabulum
• Ischial tuberosiry-supports the body in a sitting position
• Ramus-passes upward to join the inferior ramus of rhe pubis; known as rhe obturator foramen
Pelvis
Fanned by the right and left hip bones, sacrum, and coccyx
Greater pelvis
o Bounded by the ilia and lower lumbar vertebrae
o Gives support to the abdominal viscera
Lesser pelvis
o Brim of the pelvis corresponds to the sacral promontory
o Inferior outlet is bounded by the tip of the coccyx, ischial tuberosities, and inferior rami of the pubic bones
Female pelvis
o Shows adaptations related to functions as a birth canal Wide outlet
o Angle of the pubic arch is obtuse
Male pelvis
o Shows adaptations that contribute to power and speed
o Heart-shaped outlet
o Angle of the pubic arch is acute
Thigh
Femur-longest and strongest bone of the body
Proximal end has a rounded head that articulates with the acetabulum
Constricted portion-the neck
Greater and lesser trochanters
Slightly arched shaft; is concave posteriorly
o Linea aspera-strengthened by this prominent ridge
o Site of attachment for several muscles
Distal end has two condyles separated on the posterior side by the intercondyloid notch
Knee cap
Patella-sesamoid bone
Embedded in the tendon of the quadriceps muscle
Articulates with the femur
Leg
Tibia-medial bone
o Proximal end has two condyles that articulate with the femur
o Triangular shaft
Anterior-shin
Posterior-soleal line
Distal-medial malleolus that articulates with the latus to form the ankle joint
Fibula-lateral bone
o Articulates with the lateral condyle of the tibia but does not enter the knee joint
o Distal end projects as the lateral malleolus
Ankle, foot, and toes
Adapted for supporting weight but similar in structure to the hand
Talus
o Occupies the uppennost and central position in the tarsus
o Distributes the body weight from the tibia above to the other tarsal bones
Calcaneus (heel)-Iocated beneath the talus
Navicular-located in front of the talus on the medial side; articulates with three cuneifonn bones distally
Cuboid-lies along the lateral border of the navicular bone
Metatarsals
o First, second, and third p1etatarsals lie in front of the three cuneifonn bones
o (2) Fourth and fifth metatarsals lie in front of the cuboid bone
Phalanges
o Distal to the metatarsals
o (2) Two in the great toe; three in each of the other four toes .
Longitudinal arches in the foot (2)
o Lateral-fonned by the calcaneus, talus, cuboid, and fourth and fifth metatarsal bones
o Medial-fonned by the calcaneus, talus, navicular, cuneifonn, and first, second, and third metatarsal bones
Transverse arches-formed by the tarsal and metatarsal bones
Smooth Muscle
Light microscopic Structure:
cells - long - spindle shaped, nucleus lies in the widest widest part of the fiber, when the fiber contract the nucleus become folded, 30 - 200 µm long,between fibres lie endomycium
Electron microscopic structure:
Mitochondria, ribosomes, golgi, rough EPR, myofilaments are present but no sarcomeres and no Z lines,thin filaments - actin and tropomyosin (7nm), thick filaments - myosin (17nmØ)
- intermediate filaments (10 nm)
- actin and myosin overlap more than in skeletal muscle and can therefore contract more
A rudimentary sacroplasmic reticulum is present in the form of invaginations on the surface called caveolae , So there are no T-tubules, Cells communicate through gap junctions.
Dense bodies
Filaments are attached to dense bodies which take the place of the Z line in skeletal muscle
There are two types of dense bodies - cytoplasmic and membrane
contains a percentage actinin (like the Z line)
dense bodies transmit contractile force to adjacent fibres
Arrangement:
Fibres can be single or in groups, normally arranged in sheaths, In the GIT are 2 or 3 layers
Nerve supply:
2 types:
Where it is arranged in layers a few fibres are innervated together
impulse spread through the gap junctions between fibres (slow contraction)
In the iris and the vas deferens each fiber is individually supplied (quick contraction)
Structure of the Nasal Septum
- This part bony, part cartilaginous septum divides the chamber of the nose into two narrow nasal cavities.
- The bony part of the septum is usually located in the median plane until age 7; thereafter, it often deviates to one side, usually the right.
- The nasal septum has three main components: (1) the perpendicular plate of the ethmoid bone; (2) the vomer, and (3) the septal cartilage.
- The perpendicular plate, which forms the superior part of the septum, is very thin and descends from the cribiform plate of the ethmoid bone.
- The vomer, which forms the posteroinferior part of the septum, is a thin, flat bone. It articulates with the sphenoid, maxilla and palatine bones.