NEET MDS Lessons
Anatomy
ENDOCRINE
Endocrine glands have no ducts
They secrete into the blood from where the secretion (hormone) reaches a target cell
The following is a list of endocrine glands:
- Hypophysis
- Thyroid
- Parathyroid
- Adrenals
- Islets of Langerhans
- Pineal
- Gonads
Hypophysis: Develops from oral ectoderm and nerve tissue, The oral part forms an upgrowth with an invagination (Rathke's pouch) The nervous part grows from the floor of the diencephalon - staying intact .The oral part separates from the mouth
Ectoderm – adenohypophysis - pars tuberalis
- pars distalis
- pars intermedia .
Diencephalon – neurohypophysis - pars nervosa .
- infundibulum
- median eminence
Rathke's pouch remains as Rathke's cysts
Pars Distalis: Forms 75% of the gland, The cells form cords, with fenestrated capillaries in-between
2 Cell types:
Chromophobes : 50% of the cells, do not stain lie in groups, they are resting chromophils
granules have been used
Chromophils: Stain
They can be subdivided according to their reaction with different stains
Acidophils (40%) :Cells have acidophilic granules in their cytoplasm. The cells are secretory.
They have a well developed EPR and Golgi apparatus.They have secretory granules.
subdivided into:
- Somatotropin cells: secrete somatotropin (growth hormone)
- Mammotropic cells: secrete prolactin
Basophils (10%) : These cells have basophilic granules in their cytoplasm and can be subdivided into:
Thyrotropin cells: secrete thyroid - stimulating hormone (TSH)
Corticotrophin cells: secrete adrenocorticotropic (ACTH)
Gonadotropic cells: secrete two hormones: Follicle stimulating hormone (FSH):
Stimulate follicle development and spermatogenesis
Luteinizing hormone (LH): Stimulate the formation of the corpus luteum and Leydig cells
Pars Tuberalis: Cells lie around the infundibulum . It is continuous with the pars distalis
Cells are cuboidal with no granules. Their function is unknown
Pars Intermedia: Poorly developed in the human. Follicles lined by cuboidal cells and filled with colloid are found Known as Rathke's cysts .There are also a few big basophilic cells
Their function is unknown
Pars Nervosa: Contains: - myelinated axons pituicytes, blood vessels
Axons:
The cell bodies of the axons lie in the supra-optic and paraventricular nuclei of the hypothalamus .From the cell bodies the axons go through the infundibulum forming the hypothalamohypophyseal tract to end in the pars nervosa
The axons have dilated blind endings filled with hormones (Herring bodies) coming from the cell bodies.
Two hormones are secreted:
Oxytoxin: - Cause contraction of the uterus
- Cause contraction of the myoepithelial cells of the milkgland
- The hormone is secreted by the paraventricular nuclei
Vasopressin :- Cause reabsorption of H2O in the kidney (also known as antidiuretic hormone ADH) The hormone is secreted by the supraoptic nuclei. A hypophyseal portal system exists
A primary capillary plexus of fenestrated capillaries form around the median eminence. Inhibitory hormones are secreted into these capillaries
The capillaries rejoin to form the portal veins that traverse the pituitary stalk
The portal veins break up into a secondary capillary plexus which lies close to the cells of the adenohypophysis
This portal system regulates the functions of the anterior pituitary function.
Pineal
Surrounded by pia which sends septae into the gland Cells are mainly pinealocytes and astroglial cells
Pinealocytes:Irregular shaped cells. with processes ending in flattened dilatations
Have a well developed smooth surfaced endoplasmic reticulum, Also a rough EPR not well developed, Lots of microtubules
Astroglial Cells: Elongated nucleus, Cells have long processes, They perform a supporting function
Hormones:
Melatonin - secreted during the night .suppress the onset of puberty
Serotonin - secreted during the day
In humans the pineal form concretions of calcified material called brain sand
Brain sand vary in size and number with age and is visible on X-rays
Mast cells are also found in the pineal and cause the high histamine contend of the gland
THYROID
Has a CT capsule that sends septae into the gland to divide it up into incomplete lobes and lobules. In the lobules are follicles, Follicles vary in size, They are surrounded by surrounded by reticular CT and capillaries
Cells of the Follicle:
Follicular Cells : Single layer of cuboidal cells, lie around the colloid, Follicular cells can become columnar when very active, Nucleus central, EPR has wide cisternae ,Golgi present
- microvilli on the free surface
Parafollicular Cells: Also known as C-cells, Form part of the epithelium or form clusters between the follicles
- They never come into contact with the colloid
- Larger and stain less intensely than the follicular cells, Form 2% of the cells, Secrete calcitonin
Hormones: Thyroxine and thyriodothyronine - stimulate the metabolic rate, Calcitonin - lower the blood calcium
Parathyroid:
Has a CT capsule which send septae into the gland to divide it up into incomplete lobules, The CT contains fat which increase with age - may eventually be 50% of the gland, Glandular cells are arranged in cords
Glandular Cells:
Chief Cells: Small cells so their nuclei lie close together, Rich in glycogen, Biggest omponent
Secrete parathyroid hormone - essential for life
Oxyphil Cells:Develop at puberty, Bigger than the chief cells, Nuclei are smaller, Acidophilic
Hormones:
Parathyroid hormone - regulate calcium and phosphate ions in the blood
ADRENAL
- Thick CT capsule that do not send septae into the gland
Cortex:
Has 3 layers
Zona glomerulosa: 15% of the cortex, Directly under the capsule, Cells are columnar or pyramidal, Arranged in small groups or clusters, Wide fenestrated capillaries surround the clusters, Cells have an extensive smooth EPR
Zona Fasciculata: 78% of the cortex, Cells are arranged in cords ,1 to 2 cells wide perpendicular to the surface, Sinusoids lie between the cords, Cells are polyhedral with a central nucleus which is bigger than that of the zona glomerulosa, Lots of lipid in the cytoplasm cause the cells to stain lightly, Cells have a well developed smooth and rough EPR
The mitochondria in the cells are round with tubular or vesicular cristae
Zona Reticularis: 7% of the cortex, Cells form a network of cords with wide capillaries in-between The mitochondria in the cells are more ofte6n elongated than that in the zona fasciculate Degenerating cells with pyknotic nuclei are found. Cells contain numerous large lipofuscin granules. Cells of the cortex do not store their secretions but form and secrete on demand.
Hormones:
3 Groups:
Glucocorticoids (e.g. cortisol) - have an affection on carbohydrate metabolism
Mineralocorticoid (e.g. aldosterone) - control water and electrolyte balans
Androgens (e.g. dehyroepiandrosterone) - not very important
Medulla:
- Cells are big and oval and lie in groups and cords around bloodvessels
- Oxidising agents stain the granules in these cells brown - cells are therefore called chromaffin cells
- Granules contain adrenaline or non-adrernalin
- A few parasympathetic ganglion cells are also present
Hormones:
- Adrenaline - increase oxygen uptake
- increase blood pressure
- Noradrenaline - maintain blood pressure
Blood Supply:
- Blood vessel enter from the capsule to form the wide capillaries
- They flow into venules that form a central vein
- Between the endothelium of the capillaries and the glandular cells there is a subendothelial
- space.
- The glandular cells have microvilli protruding into this space.
ISLES OF LANGERHANS
Endocrine part of pancreas. The isles are round clusters in the exocrine tissue
- 100 - 200 µm
Islands consists of slightly stained polygonal or rounded cells, The cells are separated by fenestrated capillaries
- Autonomic nerve fibres innervate the blood vessels and the island cells
- 4 different cell types have been described
A cells : 20% of the cells, Bigger than B cells, Lie at the periphery, Have secretory granules ,Contain glucagon
B cells : 80%, Lie in the centre of the island, The cells are small with granules which are crystals, Granules are formed by insulin
D cells : Not numerous, Membrane bound granules, Store somatostatin (inhibit somatotropin)
F cells : Have membrane bound granules, Store pancreatic polypeptide, The hormone inhibits pancreatic exocrine secretion
Levator Palpebrae Superioris Muscles
- This is a thin, triangular muscle that elevates the upper eyelid.
- It is continuously active except during sleeping and when the eye is closing.
- Origin: roof of orbit, anterior to the optic canal.
- Insertion: this muscle fans out into a wide aponeurosis that inserts into the skin of the upper eyelid. The inferior part of the aponeurosis contains some smooth muscle fibres that insert into the tarsal plate.
- Innervation: the superior fibres are innervated by the oculomotor nerve (CN III), and the smooth muscle component is innervated by fibres of the cervical sympathetic trunk and the internal carotid plexus.
Illnesses involving the Levator Palpebrae Superioris
- In third nerve palsy, the upper eyelid droops (ptosis) and cannot be raised voluntarily.
- This results from damage to the oculomotor nerve (CN III), which supplies this muscle.
- If the cervical sympathetic trunk is interrupted, the smooth muscle component of the levator palpebrae superioris is paralysed and also causes ptosis.
- This is part of Horner's syndrome.
The Rectus Muscles
- There are four rectus muscles (L. rectus, straight), superior, inferior, medial and lateral.
- These arise from a tough tendinous cuff, called the common tendinous ring, which surrounds the optic canal and the junction of the superior and inferior orbital fissures.
- From their common origin, these muscles run anteriorly, close to the walls of the orbit, and attach to the eyeball just posterior to the sclerocorneal junction.
- The medial and lateral rectus muscles attach to the medial and lateral sides of the eyeball respectively, on the horizontal axis.
- However, the superior rectus attaches to the anterosuperior aspect of the medial side of the eyeball while the inferior rectus attaches to the anteroinferior aspect of the medial side of the eye.
The Oblique Muscles
The Superior Oblique Muscle
- This muscle arises from the body of the sphenoid bone, superomedial to the common tendinous ring.
- It passes anteriorly, superior and medial to the superior and medial rectus muscles.
- It ends as a round tendon that runs through a pulley-like loop called the trochlea (L. pulley).
- After passing though the trochlea, the tendon of the superior oblique turns posterolaterally and inserts into the sclera at the posterosuperior aspect of the lateral side of the eyeball.
The Inferior Oblique Muscle
- This muscle arises from the maxilla in the floor of the orbit.
- It passes laterally and posteriorly, inferior to the inferior rectus muscle.
- It inserts into the sclera at the posteroinferior aspect of the lateral side of the eyeball.
The Layers of the Pharyngeal Wall
- The pharyngeal wall is composed of 5 layers. From internal to external, they are as follows.
- Mucous membrane: this lines the pharynx and is continuous with all chambers with which it communicates.
- Submucosa
- Pharyngobasilar fascia: this is a fibrous layer that is attached to the skull.
- Muscular layer: this is composed of inner longitudinal and outer circular parts.
- Buccopharyngeal fascia: this is a loose connective tissue layer.
- This fascia is continuous with the fascia covering the buccinator and pharyngeal muscle.
- It contains the pharyngeal plexus of nerves and veins.
EPITHELIUMS
Epithelial Tissue Epithelial tissue covers surfaces, usually has a basement membrane, has little extracellular material, and has no blood vessels. A basement membrane attaches the epithelial cells to underlying tissues. Most epithelia have a free surface, which is not in contact with other cells. Epithelia are classified according to the number of cell layers and the shape of the cells.
- Epitheliums contain no blood vessels. There is normally an underlying layer of connective tissue
- Almost all epitheliums lie on a basement membrane.The basement membrane consists of a basal lamina and reticular lamina. The reticular lamina is connected to the basal lamina by anchoring fibrils. The reticular lamina may be absent in which case the basement membrane consist only of a basal lamina. The basal lamina consists of a - lamina densa in the middle (physical barrier) with a lamina lucida on both sides (+charge barrier),The basement membrane is absent in ependymal cells.The basement membrane is not continuous in sinusoidal capillaries.
- Epitheliums always line or cover something
- Epithelial cells lie close together with little intercellular space
- Epithelial cells are strongly connected to one another especially those epitheliums that are subjected to mechanical forces.
Functions of Epithelium:
→ Simple epithelium involved with diffusion, filtration, secretion, or absorption
→ Stratified epithelium protects from abrasion
→ Squamous cells function in diffusion or filtration
The Laryngopharynx
- The laryngeal part of the pharynx lies posterior to the larynx.
- It extends from the superior border of the epiglottis to the inferior border of the cricoid cartilage, where it narrows to become continuous with the oesophagus.
- Posteriorly, the laryngopharynx is related to the bodies of C4 to C6 vertebrae.
- Its posterior and lateral walls are formed by the middle and inferior constrictor muscles, with the palatopharyngeus and stylopharyngeus internally.
- The laryngopharynx communicates with the larynx through the aditus or inlet of the larynx.
- The piriform recess is a small, pear-shaped depression of the laryngopharyngeal cavity on each side of the inlet of the larynx.
Innervation of the Skin
- Innervation of the skin is mainly through the three branches of the trigeminal nerve (CN V).
- Some skin over the angle of the mandible and anterior and posterior of the auricle is supplied by the great auricular nerve from the cervical plexus.
- Some cutaneous branches of the auricular branch of the facial nerve also supplies skin on both sides of the auricle.
- The trigeminal nerve is the general sensory nerve to the head, particularly the face, and is the motor nerve to the muscles of mastication.
The Ophthalmic Nerve
- This is the superior division of the trigeminal nerve, the smallest of the three branches and is wholly sensory.
- The ophthalmic nerve divides into three branches: the nasociliary, frontal and lacrimal just before entering the orbit through the superior orbital fissure.
- The nasociliary nerve supplies the tip of the nose through the external nasal branch of the anterior ethmoidal nerve.
- The frontal nerve is the direct continuation of CN V1 and divides into two branches, the supraorbital and supratrochlear.
- The supratrochlear nerve supplies the middle part of the forehead.
- The supraorbital nerve supplies the lateral part and the front of the scalp.
- The lacrimal nerve, the smallest of the main ophthalmic branches, emerges over the superolateral orbital margin to supply the lacrimal gland and the lateral part of the upper eyelid.
The Maxillary Nerve
- This is the intermediate division of the trigeminal nerve.
- It has three cutaneous branches.
- The infraorbital nerve is the largest terminal branch of the maxillary nerve.
- It passes through the infraorbital foramen and breaks up into branches that supplies the skin on the lateral aspect of the nose, upper lip and lower eyelid.
- The zygomaticofacial nerve, a small branch of the maxillary, emerges from the zygomatic bone from a foramen with the same name.
- It supplies the skin over the zygomatic bone.
- The zygomaticotemporal nerve emerges from the zygomatic bone from foramen of the same name.
- It supplies the skin over the temporal region.
The Mandibular Nerve
- This is the inferior division of the trigeminal nerve.
- Of the three division of the trigeminal nerve, CN V3 is the only one that carries motor fibres (to the muscles of mastication).
- The main sensory branches of the mandibular nerve are the buccal, auriculotemporal, inferior alveolar and lingual nerves.
- The buccal nerve is a small branch of the mandibular that emerges from deep to the ramus of the mandible.
- It supplies the skin of the cheek over the buccinator muscle, the mucous membrane lining the cheek, and the buccal surface of the gingiva.
- The auriculotemporal nerve passes medially to the neck of the mandible and then turns superiorly, posterior to its head and anterior to the auricle. It then crosses over the root of the zygomatic process of the temporal bone, deep to the superficial temporal artery.
- It supplies the auricle, external acoustic meatus, tympanic membrane, and the skin in the temporal region.
- The inferior alveolar nerve is the large terminal branch of the posterior division of the mandibular nerve (the lingual nerve is the other terminal branch).
- It enters the mandible through the mandibular foramen to the mandibular canal. In the canal, it gives branches to the mandibular teeth.
- Opposite the mental foramen, this nerve divides into the mental nerve and the incisive nerve.
- The incisive nerve supplies the incisor teeth, the adjacent gingiva and the mucosa of the lower lip.
- The mental nerve emerges from the mental foramen and supplies the skin of the chin and the skin and mucous membrane of the lower lip and gingiva.
- The lingual nerve is the smaller terminal branch of the mandibular nerve.
- It supplies the general sensory fibres to the anterior two-thirds of the tongue, the floor of the mouth and the gingivae of the mandibular teeth.
- U-shaped bone
- Body
- Greater horn
- Lesser horn
- Suspended by ligaments from the styloid process