Angle classified these relationships by using the first permanent molars

Normal or neutral occlusion (ideal):

Mesiobuccalgroove of the mandibular first molar align with the mesiobuccal cusp of the max laxy first permanent molar

ClassI  malocclusion  normal molar relationships with alterations to other characteristics of the occlusion such as versions, crossbites, excessive overjets, or overbites

Class II malocclusion a distal relation of the mesiobuccal groove of the mandibular first permanent molar to the mesiobuccal cusp of the maxillary first permanent molar

Division I: protruded maxillary anterior teeth

Division II: one or more maxillary anterior teeth retruded

Class III  malocclusion a mesial relation of the mesiobuccal groove of the mandibular first permanent molar to the mesiobuccal cusp of the maxillary molar

Nerve and vascular formation

Frequently, nerves and blood vessels run parallel to each other in the body, and the formation of both usually takes place simultaneously and in a similar fashion. However, this is not the case for nerves and blood vessels around the tooth, because of different rates of development.

Nerve formation

Nerve fibers start to near the tooth during the cap stage of tooth development and grow toward the dental follicle. Once there, the nerves develop around the tooth bud and enter the dental papilla when dentin formation has begun. Nerves never proliferate into the enamel organ

Vascular formation

Blood vessels grow in the dental follicle and enter the dental papilla in the cap stage. Groups of blood vessels form at the entrance of the dental papilla. The number of blood vessels reaches a maximum at the beginning of the crown stage, and the dental papilla eventually forms in the pulp of a tooth. Throughout life, the amount of pulpal tissue in a tooth decreases, which means that the blood supply to the tooth decreases with age. The enamel organ is devoid of blood vessels because of its epithelial origin, and the mineralized tissues of enamel and dentin do not need nutrients from the blood.

TEMPOROMANDIBULAR JOINT

There are three kind of joints:
 

·  Fibrous
Two bones connected with fibrous tissue
Examples
suture (little or no movement)
gomphosis (tooth - PDL - bone)
syndesmosis (fibula & tibia, radius and ulna; interosseous ligament)

·  Cartilagenous
Two subtypes:
2a) primary: bone<--->cartilage (costochondral joint)
2b) secondary: bone<-->cartilage<-->FT<-->cartilage<--> bone (pubic symphysis)

·  Synovial
Two bones; each articular surface covered with hyaline cartilage in most cases
The bones are united with a capsule (joint cavity)
In the capsule there is presence of synovial fluid
The capsule is lined by a synovial membrane
In many synovial joints there maybe an articular disk
Synovial joints are characterized by the presence of ligaments
Synovial joints are classified according to the number of axes of bone movement: uniaxial, biaxial, multiaxial

the shapes of articulating surfaces: planar, ginglymoid (=hinged), pivot, condyloid

The movement of the joints is controlled by muscles

The temporomandibular joint is a synovial, sliding-ginglymoid joint (humans)

Embryology of the TMJ
Primary TMJ: Meckel's cartilage --> malleus & incal cartilage. It lasts for 4 months.
Secondary TMJ: Starts developing around the third month of gestation
Two blastemas (temporal and condylar); condylar grows toward the temporal (temporal appears and ossifies first)
Formation of two cavities: inferior and upper
Appearance of disk
Bones: glenoid fossa (temporal bone) and condyle (mandible)
 

Structure

There are 3 pairs

 The functional unit is the adenomere.

The adenomere consists of secreting units and an intercalated duct, which opens, in a striated duct.

An secreting unit can be:

- mucous secreting

- serous secreting

THE SECRETING UNIT

THE CELLS

Serous cells

(seromucus cells=secrete also polysaccharides), They have all the features of a cell specialized for the synthesis, storage, and secretion of protein
 Pyramidal, Nuclei are rounded and more centrally placed,  In the basal 1/3 there is an accumulation of Granular EPR,  In the apex there are proteinaceous secretory granules,  Cells stain well with H & E (red),  Between cells are intercellular secretory capillaries

Rough endoplasmic reticulum (ribosomal sites-->cisternae)
Prominent Golgi-->carbohydrate moieties are added
Secretory granules-->exocytosis
The secretory process is continuous but cyclic
There are complex foldings of cytoplasmic membrane
The junctional complex consists of: 1) tight junctions (zonula occludens)-->fusion of outer cell layer, 2) intermediate junction (zonula adherens)-->intercellular communication, 3)desmosomes-->firm adhesion

Mucus cells

Pyramidal,  Nuclei are flattened and near the base,  Have big clear secretory granules

Cells do not stain well with H & E (white)

Production, storage, and secretion of proteinaceous material; smaller enzymatic component
-more carbohydrates-->mucins=more prominent Golgi
-less prominent (conspicuous) rough endoplasmic reticulum, mitochondria
-less interdigitations
 

Myoepithelial cells

Star-shaped, Centrally located nucleus, Long cytoplasmic arms - bound to the secretory cells by desmosomes, Have fibrils like smooth muscle, Squeeze the secretory cell

One, two or even three myoepithelial cells in each salivary and piece body, four to eight processes
Desmosomes between myoepithelial cells and secretory cells myofilaments frequently aggregated to form dark bodies along the course of the process. The myoepithelial cells of the intercalated ducts are more spindled-shaped and fewer processes
Ultrastructure very similar to that of smooth muscle cells (myofilaments, desmosomal attachments)
 

Functions of myoepithelial cells
-Support secretory cells
-Contract and widen the diameter of the intercalated ducts
-Contraction may aid in the rupture of acinar cells of epithelial origin

Ductal system

Three classes of ducts:
Intercalated ducts

They have small diameter; lined by small cuboidal cells; nucleus located in the center. They have a well-developed RER, Golgi apparatus, occasionally secretory granules, few microvilli. Myoepithelial cells are also present. Intercalated ducts are prominent in salivary glands having a watery secretion (parotid).
Striated ducts

They have columnar cells, a centrally located nucleus, eosinophilic cytoplasm. Prominenty striations that refer to indentations of the cytoplasmic membrane with many mitochondria present between the folds. Some RER and some Golgi. The cells have short microvilli.
The cells of the striated ducts modify the secretion (hypotonic solution=low sodium and chloride and high potassium). There is also presence of few basal cells.
Terminal excretory ducts

Near the striated ducts they have the same histology as the striated ducts. As the duct reaches the oral mucosa the lining becomes stratified. In the terminal ducts one can find goblet cells, basal cells, clear cells. The terminal ducts alter the electrolyte concentration and add mucoid substance.

Connective tissue
Presence of fibroblasts, inflammatory cells, mast cells, adipose cells
Extracellular matrix (glycoproteins and proteoglycans)
Collagen and oxytalan fibers
 

 Nerve supply
The innervation of salivary glands is very complicated. There is no direct inhibitory innervation. There are parasympathetic and sympathetic impulses, the parasympathetic are more prevalent.
The parasympathetic impulses may occur in isolation, evoke most of the fluid to be excreted, cause exocytosis, induce contraction of myoepithelial cells (sympathetic too) and cause vasodialtion. There are two types of innervation: epilemmal and hypolemmal. There are beta-adrenergic receptors that induce protein secretion and L-adrenergic and cholinergic receptors that induce water and electrolyte secretion.

Hormones can influence the function of the salivary glands. They modify the salivary content but cannot initiate salivary flow.

Age changes

Fibrosis and fatty degenerative changes
Presence of oncocytes (eosinophilic cells containing many mitochondria)

Clinical considerations

Role of drugs, systemic disorders, bacterial or viral infections, therapeutic radiation, obstruction, formation of plaque and calculus.

    - Rich capillary networks surround the adenomeres.

The mixed dentition

I. Transition dentition between 6 and 12 years of age with primary tooth exfoliation and permanent tooth eruption

2. Its characteristic features have led this to be called the ugly duckling stage because of

a. Edentulated areas

b. Disproportionately sized teeth

c. Various clinical crown heights

d. Crowding

e. Enlarged and edematous gingiva

f. Different tooth colors

ERUPTION

. Root completion (approximately 50% of the root is formed when eruption begins)

Generally mandibular teeth erupt before maxillary teeth,

Primary teeth

I. Emerge into the oral cavity as follows:

           Maxillary                       Mandibular

Central Incisor                          7½ months                     6 months

Lateral incisor                           9 months                       7 months

Canine                                     18 months                      16 months

First Molar                               14 months                     12 months

Second Molar                          24months                       20 months

The sequence of  primary  tooth development is central incisor, lateral incisor, first molar, second molar

3. Hard tissue formation begins between 4 and 6 months in utero

4. Crowns completed between 1½ and 10 months of age

5. Roots are completed between I½ and3 yearsof age 6 to 18 months after eruption

6. By age 3 years all of the primary and permanent teeth (except for the third molars) are in some stage of development

7. Root resorption of primary teeth is triggered by the pressure exerted by the developing permanent tooth; it is followed by primary tooth exfoliation in sequential patterns

8. The primary dentition ends when the first permanent tooth erupts