NEET MDS Lessons
Pharmacology
Sufentanil
- A synthetic opioid related to fentanyl.
- About 7 times more potent than fentanyl.
- Has a slightly more rapid onset of action than fentanyl.
FUNDAMENTALS OF INJECTION TECHNIQUE
There are 6 basic techniques for achieving local anesthesia of the structures of the oral cavity:
1. Nerve block
2. Field block
3. Infiltration/Supraperiosteal
4. Topical
5. Periodontal ligament (PDL)
6. Intraosseous
Nerve block- Nerve block anesthesia requires local anesthetic to be deposited in close proximity to a nerve trunk. This results in the blockade of nerve impulses distal to this point. It is also important to note that arteries and veins accompany these nerves and can be damaged. To be effective, the local anesthetic needs to pass only through the nerve membrane to block nerve conduction Field block/Infiltration/Supraperiosteal - Field block, infiltration and supraperiosteal injection techniques, rely on the ability of local anesthetics to diffuse through numerous structures to reach the nerve or nerves to be anesthetized:
- Periosteum
- Cortical bone
- Cancellous bone
- Nerve membrane
Topical - Topical anesthetic to be effective requires diffusion through mucous membranes and nerve membrane of the nerve endings near the tissue surface
PDL/Intraosseous - The PDL and intraosseous injection techniques require diffusion of local anesthetic solution through the cancellous bone (spongy) to reach the dental plexus of nerves innervating the tooth or teeth in the immediate area of the injection. The local anesthetic then diffuses through the nerve membrane
Buspirone
1. Short half-life (2–4 hours).
2. Relieves anxiety.
3. Does not act as an anticonvulsant.
4. Is not a good muscle relaxant.
5. Minimum abuse potential.
Methods of general anesthesia
CIRCLE SYSTEM
*HIGH-FLOW
FRESH GAS FLOW > 3 l/min.
*LOW-FLOW
FGF ok. 1l/min.
*MINIMAL-FLOW
FGF ok. 0,5 l/min.
Types of Neurons (Function)
•There are 3 general types of neurons (nerve cells):
1-Sensory (Afferent ) neuron:A neuron that detects changes in the external or internal environment and sends information about these changes to the CNS. (e.g: rods and cones, touch receptors). They usually have long dendrites and relatively short axons.
2-Motor (Efferent) neuron:A neuron located within the CNS that controls the contraction of a muscle or the secretion of a gland. They usually have short dendrites and long axons.
2-Interneuron or association neurons: A neuron located entirely within the CNS in which they form the connecting link between the afferent and efferent neurons. They have short dendrites and may have either a short or long axon.
Benzylpenicillin (penicillin G)
Benzylpenicillin, commonly known as penicillin G, is the gold standard penicillin. Penicillin G is typically given by a parenteral route of administration because it is unstable to the hydrochloric acid of the stomach.
Indications :
bacterial endocarditis, meningitis, aspiration pneumonia, lung abscess,community-acquired pneumonia, syphilis, septicaemia in children
Oxyphenbutazone: one of the metabolites of phenylbutazone. Apazone. Similar to phenylbutazone, but less likely to cause agranulocytosis