NEET MDS Lessons
Pharmacology
Piroxicam:
Half‐life of 45 hrs. Once‐daily dosing. Delay onset of action.
High doses inhibits PMN migration, decrease oxygen radical production, inhibits lymphocyte function.
used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic,non-selective cyclooxygenase (COX) inhibitor
The risk of adverse side efects is nearly ten times higher than with other NSAIDs. Peptic ulcer (9.5 higher)
Classification
1. Natural Alkaloids of Opium
Phenanthrenes -> morphine, codeine, thebaine
Benzylisoquinolines -> papaverine, noscapine
2. Semi-synthetic Derivatives
diacetylmorphine (heroin) hydromorphone, oxymorphone hydrocodone, oxycodone
3. Synthetic Derivatives
phenylpiperidines pethidine, fentanyl, alfentanyl, sufentnyl
benzmorphans pentazocine, phenazocine, cyclazocine
propionanilides methadone
morphinans levorphanol