An ulcer is a break in the continuity of the skin or the mucous membrane.

Mode of onset:  Traumatic ulcers heal when the traumatic agent is removed., If it persists it becomes chronic as in the case of dental ulcer of the tongue. Ulcers may develop spontaneously as in the case of gumma (syphilitic ulcer). It may develop with varicose veins called varicose ulcer, which develops in the lower third of the leg.

Sometimes a malignant ulcer develops in a scar called Marjolin’s ulcer. Special features are:

 No pain - as there are no nerves. It does not spread - as there is scar tissue. No metastases - as there are no lymphatics Treatment:- Wide excision.

Classification of Ulcer

A) Pathologically

I. Non-specific ulcers:

a. Due to infected wound after trauma, that is physical or chemical agents.

b. Due to local infection example dental ulcer, pressure sore

 Specific ulcers: Caused by specific infection

a. Syphilitic ulcers (Hunterian chancre)

b. Tubercular  ulcers, actinomycosis

Trophic ulcer:- Caused by two factors:

Diminished nutrition due to inadequate blood supply to the tissues

Eg. Ulcers in Buerger’s Disease, Artherosclerosis

b. Diminished or absence of sensation of the skin leading to perforating ulcer of the foot

iv. Malignant ulcer: Due to squamous cell carcinoma, rodent ulcers and melanoma.

B) Clinical classification of ulcers

1. Acute Ulcer:  The edge is inflamed oedematous and painful with slough in the floor and n o granulation tissue. Profuse purulent Discgarge seen

2. Healing ulcers: edge sloping with bluish margin The floor is covered with a red, healthy granulation tissue.

3. Chronic or callous ulcer (non- healing) There is no tendency to heal by itself, the base is jndurated  unhealthy granulation tissue is present in the floor The edge is rounded and thickened.

Chronic ulcer occur due to:

Chronic infection , Defective circulation , Foreign body, Persistent local oedema , Malignancy , Diabetes , Malnutrition (loss of proteins), Gout

Specific Ulcers

Tubeculous Ulcer

Edge Undermined, floor contains granulation tissue a watery discharge is present. Caseous material is found in the floor of the ulcer. It usually occurs in tubercular lymphadenitis in the neck, axilla or groin.

Syphilitic Ulcer

a) Huntarian Chancre or  primary sore or hard chancre: usuaIly occurs over the genitalia especially on penis. Occurs in the primary stage of syphilis Ulcer is round or oval, it is hard,indurated, elevated and painless It feels like a button, discharges serum containing spirochetes (cork screw) which is highly infective.

b) In the Secondary stage mucous patches and condylomata occurs The ulcers are shallow white patches, of sodden thickness which occur in the mouth and tongue. Condyloma are hypertrophied epithelium with serous discharge occurring in mucocutaneous junction around the anus. The regional lymphnod (inguinal transverse chain) are enlarged.

c) In tertiary stage of syphilis gummatous ulcers occur They have a punched  out edge and wash Ieather floor. They occur on the subcutaneous bones like sternum and tibia. They are painless and refuse to heal.

Soft Sore (chanchroid)

They are painful muitiple ulcers, with copious discharge. They are caused by Bacillus Ducrey  lncubation time is 3 to 4 days. located on glans penis and prepuce is due to venereal infection. They are associated with enlarged called bilateral inguinal lymphnodes

Tropical ulcer:

a) Oriental Sore - due to L. Tropica (lieshmaniasis)

b) Ulcers and sinuses are due to guinea worm abscess

c) Histoplasmosis with multiple ulcers on the tibia.

d) Chronic ulcers due to yaws

e) Amoebic ulcers occur in colon_and rectum , flask shaped ulcers , undermined edge , caused by  Entamoeba Histolytica

Varicose Ulcer:

Associated with varicose veins. Occurs on the inner aspect of the lower third of leg , chronic ulcer The surrounding area is pigmented and eczema is present. The sore is longitudinally oval It does not penetrate the deep fascia and is painless The base is adherent to the periosteum of the tibia

Rodent ulcer

Usually Occurs on the face above a line joining the lobule of the ear to the angle of the mouth. Usually occurs at the inner canthous of the eye . Edge is raised and rolled, Erodes the deeper structures and the bone, the lyrnph nodes are not involved.

Treatment: If small wide excision is done with skin grafting, If large, radiotherapy is given.

Malignant Ulcer

Occurs due to chronic irritation as in the case of malignant ulcer of the tongue. The edge is everted. The floor is covered with slough and tumor tissue The regional lymph nodes are hard.

Initially mobile later becomes hard

Treatment: Wide excision is done.

Marjolin ulcer: Malignant Ulcer occurring on scar of Burns

Cardiovascular Effects of Sevoflurane, Halothane, and Isoflurane

• Sevoflurane:

  • Maintains cardiac index and heart rate effectively.

  • Exhibits less hypotensive and negative inotropic effects compared to halothane.

  • Cardiac output is greater than that observed with halothane.

  • Recovery from sevoflurane anesthesia is smooth and comparable to isoflurane, with a shorter time to standing than halothane.

• Halothane:

  • Causes significant decreases in mean arterial pressure, ejection fraction, and cardiac index.

  • Heart rate remains at baseline levels, but overall cardiovascular function is depressed.

  • Recovery from halothane is less favorable compared to sevoflurane and isoflurane.

• Isoflurane:

  • Preserves cardiac index and ejection fraction better than halothane.

  • Increases heart rate while having less suppression of mean arterial pressure compared to halothane.

  • Cardiac output during isoflurane anesthesia is similar to that of sevoflurane, indicating a favorable cardiovascular profile.

Excision of Lesions Involving the Jaw Bone

When excising lesions involving the jaw bone, various terminologies are used to describe the specific techniques and outcomes of the procedures.

1. Enucleation

• Enucleation refers to the separation of a lesion from the bone while preserving bone continuity. This is achieved by removing the lesion along an apparent tissue or cleavage plane, which is often defined by an encapsulating or circumscribing connective tissue envelope derived from the lesion or surrounding bone.
• Key Characteristics:
  • The lesion is contained within a defined envelope.
  • Bone continuity is maintained post-excision.

2. Curettage

• Curettage involves the removal of a lesion from the bone by scraping, particularly when the lesion is friable or lacks an intact encapsulating tissue envelope. This technique may result in the removal of some surrounding bone.
• Key Characteristics:
  • Indicates the inability to separate the lesion along a distinct tissue plane.
  • May involve an inexact or immeasurable thickness of surrounding bone.
  • If a measurable margin of bone is removed, it is termed "resection without continuity defect."

3. Marsupialization

• Marsupialization is a surgical procedure that involves the exteriorization of a lesion by removing overlying tissue to expose its internal surface. This is done by excising a portion of the lesion bordering the oral cavity or another body cavity.
• Key Characteristics:
  • Multicompartmented lesions are rendered unicompartmental.
  • The lesion is clinically cystic, and the excised tissue may include bone and/or overlying mucosa.

4. Resection Without Continuity Defect

• This term describes the excision of a lesion along with a measurable perimeter of investing bone, without interrupting bone continuity. The anatomical relationship allows for the removal of the lesion while preserving the integrity of the bone.
• Key Characteristics:
  • Bone continuity is maintained.
  • Adjacent soft tissue may be included in the resection.

5. Resection With Continuity Defect

•  This involves the excision of a lesion that results in a defect in the continuity of the bone. This is often associated with more extensive resections.
• Key Characteristics:
  • Bone continuity is interrupted.
  • May require reconstruction or other interventions to restore function.

6. Disarticulation

•  Disarticulation is a special form of resection that involves the temporomandibular joint (TMJ) and results in a continuity defect.
• Key Characteristics:
  • Involves the removal of the joint and associated structures.
  • Results in loss of continuity in the jaw structure.

7. Recontouring

•  Recontouring refers to the surgical reduction of the size and/or shape of the surface of a bony lesion or bone part. The goal is to reshape the bone to conform to the adjacent normal bone surface or to achieve an aesthetic result.
• Key Characteristics:
  • May involve lesions such as bone hyperplasia, torus, or exostosis.
  • Can be performed with or without complete eradication of the lesion (e.g., fibrous dysplasia).

Advanced Trauma Life Support (ATLS)

Introduction

Trauma is a leading cause of death, particularly in the first four decades of life, and ranks as the third most common cause of death overall. The Advanced Trauma Life Support (ATLS) program was developed to provide a systematic approach to the management of trauma patients, ensuring that life-threatening conditions are identified and treated promptly.

Mechanisms of Injury

In trauma, injuries can be classified based on their mechanisms:

Overt Mechanisms

1. Penetrating Trauma: Injuries caused by objects that penetrate the skin and underlying tissues.
2. Blunt Trauma: Injuries resulting from impact without penetration, such as collisions or falls.
3. Thermal Trauma: Injuries caused by heat, including burns.
4. Blast Injury: Injuries resulting from explosions, which can cause a combination of blunt and penetrating injuries.

Covert Mechanisms

1. Blunt Trauma: Often results in internal injuries that may not be immediately apparent.
2. Penetrating Trauma: Can include knife wounds and other sharp objects.
3. Penetrating Knife: Specific injuries from stabbing.
4. Gunshot Injury: Injuries caused by firearms, which can have extensive internal damage.

The track of penetrating injuries can often be identified by the anatomy involved, helping to determine which organs may be injured.

Steps in ATLS

The ATLS protocol consists of a systematic approach to trauma management, divided into two main surveys:

1. Primary Survey

• Objective: Identify and treat life-threatening conditions.
• Components:
  • A - Airway: Ensure the airway is patent. In patients with a Glasgow Coma Scale (GCS) of 8 or less, immediate intubation is necessary. Maintain cervical spine stability.
  • B - Breathing: Assess ventilation and oxygenation. Administer high-flow oxygen via a reservoir mask. Identify and treat conditions such as tension pneumothorax, flail chest, massive hemothorax, and open pneumothorax.
  • C - Circulation: Evaluate circulation based on:
    • Conscious level (indicates cerebral perfusion)
    • Skin color
    • Rapid, thready pulse (more reliable than blood pressure)
  • D - Disability: Assess neurological status using the Glasgow Coma Scale (GCS).
  • E - Exposure: Fully expose the patient to assess for injuries on the front and back.

2. Secondary Survey

• Objective: Conduct a thorough head-to-toe examination to identify all injuries.
• Components:
  • AMPLE: A mnemonic to gather important patient history:
    • A - Allergy: Any known allergies.
    • M - Medications: Current medications the patient is taking.
    • P - Past Medical History: Relevant medical history.
    • L - Last Meal: When the patient last ate.
    • E - Events of Incident: Details about the mechanism of injury.

Triage

Triage is the process of sorting patients based on the severity of their condition. The term "triage" comes from the French word meaning "to sort." In trauma settings, patients are categorized using a color-coded system:

• Red: First priority (critical patients, e.g., tension pneumothorax).
• Yellow: Second priority (urgent cases, e.g., pelvic fracture).
• Green: Third priority (minor injuries, e.g., simple fracture).
• Black: Zero priority (patients who are dead or unsalvageable).

Blunt Trauma

• Common Causes: The most frequent cause of blunt trauma is road traffic accidents.
• Seat Belt Use: Wearing seat belts significantly reduces mortality rates:
  • Front row occupants: 45% reduction in death rate.
  • Rear seat belt use: 80% reduction in death rate for front seat occupants.
• Seat Belt Injuries: Marks on the thorax indicate a fourfold increase in thoracic injuries, while abdominal marks indicate a threefold increase in abdominal injuries.

Radiographs in Trauma

Key radiographic views to obtain in trauma cases include:

1. Lateral cervical spine
2. Anteroposterior chest
3. Anteroposterior pelvis

Types of Brain Injury

Brain injuries can be classified into two main categories: primary and secondary injuries. Understanding these types is crucial for effective diagnosis and management.

1. Primary Brain Injury

• Definition: Primary brain injury occurs at the moment of impact. It results from the initial mechanical forces applied to the brain and can lead to immediate damage.
• Examples:
  • Contusions: Bruising of brain tissue.
  • Lacerations: Tears in brain tissue.
  • Concussions: A temporary loss of function due to trauma.
  • Diffuse axonal injury: Widespread damage to the brain's white matter.

2. Secondary Brain Injury

• Definition: Secondary brain injury occurs after the initial impact and is often preventable. It results from a cascade of physiological processes that can exacerbate the initial injury.
• Principal Causes:
  • Hypoxia: Reduced oxygen supply to the brain, which can worsen brain injury.
  • Hypotension: Low blood pressure can lead to inadequate cerebral perfusion.
  • Raised Intracranial Pressure (ICP): Increased pressure within the skull can compress brain tissue and reduce blood flow.
  • Reduced Cerebral Perfusion Pressure (CPP): Insufficient blood flow to the brain can lead to ischemia.
  • Pyrexia: Elevated body temperature can increase metabolic demands and worsen brain injury.

Glasgow Coma Scale (GCS)

The Glasgow Coma Scale is a clinical tool used to assess a patient's level of consciousness and neurological function. It consists of three components: eye opening, verbal response, and motor response.

Eye Opening (E)

• Spontaneous: 4
• To verbal command: 3
• To pain stimuli: 2
• No eye opening: 1

Verbal Response (V)

• Normal, oriented: 5
• Confused: 4
• Inappropriate words: 3
• Sounds only: 2
• No sounds: 1

Motor Response (M)

• Obeys commands: 6
• Localizes to pain: 5
• Withdrawal flexion: 4
• Abnormal flexion (decorticate): 3
• Extension (decerebrate): 2
• No motor response: 1

Scoring

• Best Possible Score: 15/15 (fully alert and oriented)
• Worst Possible Score: 3/15 (deep coma or death)
• Intubated Cases: For patients who are intubated, the verbal score is recorded as "T."
• Intubation Indication: Intubation should be performed if the GCS score is less than or equal to 8.

Additional Assessments

Pupil Examination

• Pupil Reflex: Assess size and light response.
• Uncal Herniation: In cases of mass effect on the ipsilateral side, partial third nerve dysfunction may be noted, characterized by a larger pupil with sluggish reflex.
• Hutchinson Pupil: As third nerve compromise increases, the ipsilateral pupil may become fixed and dilated.

Signs of Base of Skull Fracture

• Raccoon Eyes: Bilateral periorbital hematoma, indicating possible skull base fracture.
• Battle’s Sign: Bruising over the mastoid process, suggesting a fracture of the temporal bone.
• CSF Rhinorrhea or Otorrhea: Leakage of cerebrospinal fluid from the nose or ear, indicating a breach in the skull base.
• Hemotympanum: Blood in the tympanic cavity, often seen with ear bleeding.

SHOCK

Shock  is  defined  as  a  pathological  state  causing  inadequate  oxygen  delivery  to  the peripheral tissues and resulting in lactic acidosis, cellular hypoxia and disruption of normal metabolic condition.

CLASSIFICATION

Shock is generally classified into three major categories:

1.    Hypovolemic shock

2.    Cardiogenic shock

3.    Distributive shock

Distributive shock is further subdivided into three subgroups:

a.    Septic shock

b.    Neurogenic shock

c.    Anaphylactic shock

Hypovolemic  shock  is  present  when  marked  reduction  in  oxygen  delivery results from diminished cardiac output secondary to inadequate vascular volume. In general, it results from loss of fluid from circulation, either directly or indirectly.
e.g.    ?    Hemorrhage
    •    Loss of plasma due to burns
    •    Loss of water and electrolytes in diarrhea
    •    Third space loss (Internal fluid shift into inflammatory exudates in
        the peritoneum, such as in pancreatitis.)

Cardiogenic shock is present when there is severe reduction in oxygen delivery secondary to impaired cardiac function. Usually it is due to myocardial infarction or pericardial tamponade.

Septic Shock (vasogenic shock) develops as a result of the systemic effect of infection. It is the result of a septicemia with endotoxin and exotoxin release by gram-negative and gram-positive bacteria. Despite normal or increased cardiac output and oxygen delivery, cellular oxygen consumption is less than normal due to impaired extraction as a result of impaired metabolism.

Neurogenic shock results primarily from the disruption of the sympathetic nervous system which may be due to pain or loss of sympathetic tone, as in spinal cord injuries.

PATHO PHYSIOLOGY OF SHOCK

Shock stimulates a physiologic response. This circulatory response to hypotension is to conserve perfusion to the vital organs (heart and brain) at the expense of other tissues. Progressive vasoconstriction of skin, splanchnic and renal vessels leads to renal cortical necrosis and acute renal failure. If not corrected in time, shock leads to organ failure and sets up a vicious circle with hypoxia and acidosis.

CLINICAL FEATURES

The clinical presentation varies according to the cause. But in general patients with hypotension and reduced tissue perfusion presents with:
•    Tachycardia
•    Feeble pulse
•    Narrow pulse pressure
•    Cold extremities (except septic shock)
•    Sweating, anxiety
•    Breathlessness / Hyperventilation
•    Confusion leading to unconscious state

PATHO PHYSIOLOGY OF SHOCK

Shock stimulates a physiologic response. This circulatory response to hypotension is to conserve perfusion to the vital organs (heart and brain) at the expense of other tissues. Progressive vasoconstriction of skin, splanchnic and renal vessels leads to renal cortical necrosis and acute renal failure. If not corrected in time, shock leads to organ failure and sets up a vicious circle with hypoxia and acidosis.

CLINICAL FEATURES

The clinical presentation varies according to the cause. But in general patients with hypotension and reduced tissue perfusion presents with:
•    Tachycardia
•    Feeble pulse
•    Narrow pulse pressure
•    Cold extremities (except septic shock)
•    Sweating, anxiety
•    Breathlessness / Hyperventilation
•    Confusion leading to unconscious state