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General Medicine

Immunological Profile

  • T4:T8 Ratio: 1:1 in healthy periodontitis patients
  • HIV Association: Altered ratio of 0.6:1 indicates immunocompromise

Radiographic Changes

  • First Sign: Fuzziness or break in lamina dura at alveolar crest
  • Progression: Loss of cortical outline, trabecular pattern changes
  • Most Severe Changes: Occur along the lateral wall of the periodontal pocket

Finger Rests in Dental Instrumentation

Use of finger rests is essential for providing stability and control during procedures. A proper finger rest allows for more precise movements and reduces the risk of hand fatigue.

Importance of Finger Rests

  • Stabilization: Finger rests serve to stabilize the hand and the instrument, providing a firm fulcrum that enhances control during procedures.
  • Precision: A stable finger rest allows for more accurate instrumentation, which is crucial for effective treatment and patient safety.
  • Reduced Fatigue: By providing support, finger rests help reduce hand and wrist fatigue, allowing the clinician to work more comfortably for extended periods.

Types of Finger Rests

  1. Conventional Finger Rest:

    • Description: The finger rest is established on the tooth surfaces immediately adjacent to the working area.
    • Application: This is the most common type of finger rest, providing direct support for the hand while working on a specific tooth. It allows for precise movements and control during instrumentation.
  2. Cross Arch Finger Rest:

    • Description: The finger rest is established on the tooth surfaces on the other side of the same arch.
    • Application: This technique is useful when working on teeth that are not directly adjacent to the finger rest. It provides stability while allowing access to the working area from a different angle.
  3. Opposite Arch Finger Rest:

    • Description: The finger rest is established on the tooth surfaces of the opposite arch (e.g., using a mandibular arch finger rest for instrumentation on the maxillary arch).
    • Application: This type of finger rest is particularly beneficial when accessing the maxillary teeth from the mandibular arch, providing a stable fulcrum while maintaining visibility and access.
  4. Finger on Finger Rest:

    • Description: The finger rest is established on the index finger or thumb of the non-operating hand.
    • Application: This technique is often used in areas where traditional finger rests are difficult to establish, such as in the posterior regions of the mouth. It allows for flexibility and adaptability in positioning.

  • ANUG Staging:
    • Stage 1 – 2: NUG/NUP
    • Stage 3 – 4: NUP
    • Stage 5 – 6: Necrotizing stomatitis
    • Stage 7: Noma
  • Bone Defects:
    • 3-wall: Intrabony
    • 2-wall: Crater
    • 1-wall: Hemiseptum
  • Radiographic Signs: Fuzziness in lamina dura is earliest sign.
  • TFO (Trauma from Occlusion): Widened PDL, thickened lamina dura.
  • Most Susceptible Area: Furcation.

Wilson's disease is an autosomal recessive disorder of copper metabolism caused by mutations in the ATP7B gene, resulting in impaired biliary copper excretion and toxic copper accumulation in tissues.

Pathophysiology

  • Basic defect: Decreased biliary copper excretion due to defective ATP7B protein
  • Mechanism: Impaired incorporation of copper into ceruloplasmin and reduced copper transport into bile
  • Result: Copper accumulation in liver, brain, cornea, and other organs

Clinical Manifestations

Hepatic (Most common initial presentation)

  • Acute hepatitis
  • Chronic hepatitis
  • Cirrhosis
  • Fulminant hepatic failure

Neurological

  • Movement disorders (tremor, dystonia, chorea)
  • Psychiatric symptoms (depression, psychosis, behavioral changes)
  • Dysarthria and dysphagia
  • Cognitive impairment

Ophthalmologic

  • Kayser-Fleischer rings (pathognomonic copper deposits in Descemet's membrane)
  • Sunflower cataracts

Other Features

  • Renal tubular acidosis
  • Hemolytic anemia
  • Arthritis
  • Cardiomyopathy (rare)

Diagnostic Workup

  • Serum ceruloplasmin: Usually decreased (<20 mg/dL)
  • 24-hour urine copper: Elevated (>100 μg/24h)
  • Hepatic copper content: Gold standard (>250 μg/g dry weight)
  • Ophthalmologic examination: Slit-lamp for Kayser-Fleischer rings
  • Genetic testing: ATP7B gene mutations
  • Brain MRI: "Face of giant panda" sign in severe cases

Treatment

Chelation Therapy

  • D-penicillamine: First-line, may worsen neurological symptoms initially
  • Trientine: Alternative chelator, better tolerated neurologically
  • Tetrathiomolybdate: For neurological presentations

Zinc Therapy

  • Zinc acetate/sulfate: Blocks copper absorption, maintenance therapy
  • Preferred for asymptomatic patients and maintenance

Gingival Crevicular Fluid (GCF)

Gingival crevicular fluid is an inflammatory exudate found in the gingival sulcus. It plays a significant role in periodontal health and disease.

A. Characteristics of GCF

  • Glucose Concentration: The glucose concentration in GCF is 3-4 times greater than that in serum, indicating increased metabolic activity in inflamed tissues.
  • Protein Content: The total protein content of GCF is much less than that of serum, reflecting its role as an inflammatory exudate.
  • Inflammatory Nature: GCF is present in clinically normal sulci due to the constant low-grade inflammation of the gingiva.

B. Drugs Excreted Through GCF

  • Tetracyclines and Metronidazole: These antibiotics are known to be excreted through GCF, making them effective for localized periodontal therapy.

C. Collection Methods for GCF

GCF can be collected using various techniques, including:

  1. Absorbing Paper Strips/Blotter/Periopaper: These strips absorb fluid from the sulcus and are commonly used for GCF collection.
  2. Twisted Threads: Placing twisted threads around and into the sulcus can help collect GCF.
  3. Micropipettes: These can be used for precise collection of GCF in research settings.
  4. Intra-Crevicular Washings: Flushing the sulcus with a saline solution can help collect GCF for analysis.

Microbes in Periodontics

Bacteria Associated with Periodontal Health

  • Primary Species:

    • Gram-Positive Facultative Bacteria:
      • Streptococcus:
        • S. sanguis
        • S. mitis
        • A. viscosus
        • A. naeslundii
      • Actinomyces:
        • Beneficial for maintaining periodontal health.
  • Protective or Beneficial Bacteria:

    • Key Species:
      • S. sanguis
      • Veillonella parvula
      • Corynebacterium ochracea
    • Characteristics:
      • Found in higher numbers at inactive periodontal sites (no attachment loss).
      • Low numbers at sites with active periodontal destruction.
      • Prevent colonization of pathogenic microorganisms (e.g., S. sanguis produces peroxide).
  • Clinical Relevance:

    • High levels of C. ochracea and S. sanguis are associated with greater attachment gain post-therapy.

Microbiology of Chronic Plaque-Induced Gingivitis

  • Composition:

    • Roughly equal proportions of:
      • Gram-Positive: 56%
      • Gram-Negative: 44%
      • Facultative: 59%
      • Anaerobic: 41%
  • Predominant Gram-Positive Species:

    • S. sanguis
    • S. mitis
    • S. intermedius
    • S. oralis
    • A. viscosus
    • A. naeslundii
    • Peptostreptococcus micros
  • Predominant Gram-Negative Species:

    • Fusobacterium nucleatum
    • Porphyromonas intermedia
    • Veillonella parvula
    • Haemophilus spp.
    • Capnocytophaga spp.
    • Campylobacter spp.
  • Pregnancy-Associated Gingivitis:

    • Increased levels of steroid hormones and P. intermedia.

Chronic Periodontitis

  • Key Microbial Species:

    • High levels of:
      • Porphyromonas gingivalis
      • Bacteroides forsythus
      • Porphyromonas intermedia
      • Campylobacter rectus
      • Eikenella corrodens
      • Fusobacterium nucleatum
      • Actinobacillus actinomycetemcomitans
      • Peptostreptococcus micros
      • Treponema spp.
      • Eubacterium spp.
  • Pathogenic Mechanisms:

    • P. gingivalis and A. actinomycetemcomitans can invade host tissue cells.
    • Viruses such as Epstein-Barr Virus-1 (EBV-1) and human cytomegalovirus (HCMV) may contribute to bone loss.

Localized Aggressive Periodontitis

  • Microbiota Characteristics:
    • Predominantly gram-negative, capnophilic, and anaerobic rods.
    • Almost all localized juvenile periodontitis (LJP) sites harbor A. actinomycetemcomitans, which can comprise up to 90% of the total cultivable microbiota.

  • Plaque & Bacteria:
    • Plaque: Mainly extracellular polysaccharides.
    • Pellicle: Thin film post-cleaning.
    • Bacteria in 1g plaque: 2 ื 10นน.
    • Early plaque: Gram-positive.
    • Saliva: Streptococci dominate.
    • First oral colonizer: S. sanguis.
    • Secondary colonizer: S. mutans.
    • Red Complex: Most associated with periodontal disease.
    • Green Complex: A. actinomycetemcomitans, E. corrodens, Capnocytophaga.
  • Tests & Toxins:
    • BANA test: Detects P. gingivalis, T. denticola, B. forsythia.
    • Leukotoxin (116-kDa): Secreted by A. actinomycetemcomitans.
    • Myeloperoxidase: Prevents A. viscosus attachment.
  • Immunoglobulins:
    • Saliva: IgA.
    • GCF: IgG.
  • GCF Lymphocyte Ratio: T:B = 1:3.
  • TLRs: Absent on bacterial cells.

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