NEET MDS Lessons
General Medicine
| Type | Key Feature |
|---|---|
| Beta Thalassemia | ↓ Beta chains, ↑ Alpha chains |
| Common mutation | Intron-1 |
| Diagnosis | Hb electrophoresis |
| Screening test | NESTROFT |
| Radiology sign | Hair-on-end skull appearance |
- Alpha Thalassemia: Caused by deletion of alpha genes
- HbH Disease: Deletion of 3 alpha chains
Blade Angulation Protocols
Scaling & Root Planing
- Angulation: 45-90 degrees to tooth surface
- Purpose: Effective calculus removal and root surface debridement
Gingival Curettage
- Angulation: >90 degrees
- Technique: Removal of infected soft tissue from pocket wall
Curette Sharpening
- Optimal Angle: 100-110 degrees
- Maintenance: Critical for effective instrumentation
Curette Design
Gracey Curettes
- Offset Angle: 60 degrees
- Specificity: Area-specific design for different tooth surfaces
Universal Curettes
- Angle: 90 degrees
- Application: Suitable for all tooth surfaces
After-Five Curettes
- Modification: Terminal shank extended by 3mm
- Purpose: Access to deep pockets (>5mm)
Probing Systems
CPITN Probe
- Tip Diameter: 0.5mm
- Markings: 3.5, 5.5, 8.5, 11.5mm
- Use: Community periodontal index assessment
Florida Probe
- Tip Diameter: 0.4mm (more precise)
- Technology: Computerized probing system
Implant Probing
- Maximum Force: 25N
- Probe Type: Plastic probes recommended to prevent implant surface damage
Pathophysiology
- Enzyme defect: Glucose-6-phosphate dehydrogenase deficiency
- Result: Impaired NADPH production → reduced glutathione → oxidative damage
- Inheritance: X-linked recessive (affects males predominantly)
Key Clinical Features
- Heinz bodies: Characteristic finding (precipitated denatured hemoglobin)
- Hemolytic episodes: Triggered by oxidative stress
- Chronic hemolysis: Usually absent between episodes
- Neonatal jaundice: May be severe
Important Clinical Points
- Estrogen does NOT induce hemolysis (unlike other conditions)
- Favism: Hemolysis after eating fava beans
- Drug-induced: Most common trigger for hemolytic crisis
Oxidative Stressors to Avoid
Medications
- Antimalarials: Primaquine, chloroquine
- Antibiotics: Sulfonamides, nitrofurantoin, chloramphenicol
- Analgesics: Aspirin (high doses), phenazopyridine
- Others: Methylene blue, naphthalene (mothballs)
Infections
- Bacterial infections
- Viral hepatitis
- Pneumonia
- Typhoid fever
Other Triggers
- Fava beans (favism)
- Diabetic ketoacidosis
- Severe illness/stress
- Mineral Sources:
- Supragingival: Saliva
- Subgingival: GCF
- Crystal Composition:
Crystal Type Percentage Hydroxyapatite 58% Magnesium whitlockite 21% Octacalcium phosphate 12% Brushite 8% - Color:
- Supragingival: White/yellow
- Subgingival: Dark brown/green-black
- Stains:
- Green: Chromogenic bacteria
- Yellow-brown: Chlorhexidine
🗣 Speech & Language
| Area | Location | Damage Effect |
|---|---|---|
| Broca’s | Dominant inferior frontal gyrus | Motor aphasia (impaired expression) |
| Wernicke’s | Dominant superior temporal gyrus | Fluent but irrelevant speech |
😵💫 Headache & Migraine
- Pain-sensitive meningeal layer: Dura
- Ophthalmoplegic migraine: III nerve palsy
- Telcagepant: New anti-migraine drug
🧠 Stroke & Hemorrhage
- Stroke in young women (India): Cortical vein thrombosis
- Commonest CVA cause: Embolism
- ICH most commonly due to: Intracerebral hemorrhage (trauma)
- Infarction site → hemiplegia: MCA territory
- Thrombolytic for stroke: Tissue plasminogen activator (tPA)
- Carotid stenosis management: Aspirin reduces TIA risk
🧠 Cranial Nerves
- Trigeminal nerve disorder: Tic Douloureux
- UMN VII palsy: Contralateral lower face paresis
- Ramsay – Hunt syndrome: Herpes virus
- Griesinger’s sign: Sigmoid sinus thrombosis
🧠 Parkinsonism
- Cause: Wilson disease (Copper accumulation)
- Lazabemide: MAO-B inhibitor
Causes
- Volatile sulfur compounds: H₂S, methyl mercaptan, dimethyl sulfide
Detection Methods
- Gold standard: Organoleptic rating (easiest)
- Most sensitive: Gas chromatography
- ANUG Staging:
- Stage 1 – 2: NUG/NUP
- Stage 3 – 4: NUP
- Stage 5 – 6: Necrotizing stomatitis
- Stage 7: Noma
- Bone Defects:
- 3-wall: Intrabony
- 2-wall: Crater
- 1-wall: Hemiseptum
- Radiographic Signs: Fuzziness in lamina dura is earliest sign.
- TFO (Trauma from Occlusion): Widened PDL, thickened lamina dura.
- Most Susceptible Area: Furcation.