Biology of tooth movement

1. Periodontal Ligament (PDL)

• Structure: The PDL is a fibrous connective tissue that surrounds the roots of teeth and connects them to the alveolar bone. It contains various cells, including fibroblasts, osteoblasts, osteoclasts, and immune cells.
• Function: The PDL plays a crucial role in transmitting forces applied to the teeth and facilitating tooth movement. It also provides sensory feedback and helps maintain the health of the surrounding tissues.

2. Mechanotransduction

• Mechanotransduction is the process by which cells convert mechanical stimuli into biochemical signals. When a force is applied to a tooth, the PDL experiences compression and tension, leading to changes in cellular activity.
• Cellular Response: The application of force causes deformation of the PDL, which activates mechanoreceptors on the surface of PDL cells. This activation triggers a cascade of biochemical events, including the release of signaling molecules such as cytokines and growth factors.

3. Bone Remodeling

• Osteoclasts and Osteoblasts: The biological response to mechanical forces involves the coordinated activity of osteoclasts (cells that resorb bone) and osteoblasts (cells that form new bone).
  • Compression Side: On the side of the tooth where pressure is applied, osteoclasts are activated, leading to bone resorption. This allows the tooth to move in the direction of the applied force.
  • Tension Side: On the opposite side, where tension is created, osteoblasts are stimulated to deposit new bone, anchoring the tooth in its new position.
• Bone Remodeling Cycle: The process of bone remodeling is dynamic and involves the continuous resorption and formation of bone. This cycle is influenced by the magnitude, duration, and direction of the applied forces.

4. Inflammatory Response

• Role of Cytokines: The application of orthodontic forces induces a localized inflammatory response in the PDL. This response is characterized by the release of pro-inflammatory cytokines (e.g., interleukins, tumor necrosis factor-alpha) that promote the activity of osteoclasts and osteoblasts.
• Healing Process: The inflammatory response is essential for initiating the remodeling process, but excessive inflammation can lead to complications such as root resorption or delayed tooth movement.

5. Vascular and Neural Changes

• Blood Supply: The PDL has a rich blood supply that is crucial for delivering nutrients and oxygen to the cells involved in tooth movement. The application of forces can alter blood flow, affecting the metabolic activity of PDL cells.
• Nerve Endings: The PDL contains sensory nerve endings that provide feedback about the position and movement of teeth. This sensory input is important for the regulation of forces applied during orthodontic treatment.

6. Factors Influencing Tooth Movement

• Magnitude and Duration of Forces: The amount and duration of force applied to a tooth significantly influence the biological response and the rate of tooth movement. Light, continuous forces are generally more effective and less damaging than heavy, intermittent forces.
• Age and Biological Variability: The biological response to orthodontic forces can vary with age, as younger individuals tend to have more active remodeling processes. Other factors, such as genetics, hormonal status, and overall health, can also affect tooth movement.

Angle’s Classification of Malocclusion

Malocclusion refers to the misalignment or incorrect relationship between the teeth of the two dental arches when they come into contact as the jaws close. Understanding occlusion is essential for diagnosing and treating orthodontic issues.

Definitions

• Occlusion: The contact between the teeth in the mandibular arch and those in the maxillary arch during functional relations (Wheeler’s definition).
• Malocclusion: A condition characterized by a deflection from the normal relation of the teeth to other teeth in the same arch and/or to teeth in the opposing arch (Gardiner, White & Leighton).

Importance of Classification

Classifying malocclusion serves several purposes:

• Grouping of Orthodontic Problems: Helps in identifying and categorizing various orthodontic issues.
• Location of Problems: Aids in pinpointing specific areas that require treatment.
• Diagnosis and Treatment Planning: Facilitates the development of effective treatment strategies.
• Self-Communication: Provides a standardized language for orthodontists to discuss cases.
• Documentation: Useful for recording and tracking orthodontic problems.
• Epidemiological Studies: Assists in research and studies related to malocclusion prevalence.
• Assessment of Treatment Effects: Evaluates the effectiveness of orthodontic appliances.

Normal Occlusion

Molar Relationship

According to Angle, normal occlusion is defined by the relationship of the mesiobuccal cusp of the maxillary first molar aligning with the buccal groove of the mandibular first molar.

Angle’s Classification of Malocclusion

Edward Angle, known as the father of modern orthodontics, first published his classification in 1899. The classification is based on the relationship of the mesiobuccal cusp of the maxillary first molar to the buccal groove of the mandibular first molar. It is divided into three classes:

Class I Malocclusion (Neutrocclusion)

• Definition: Normal molar relationship is present, but there may be crowding, misalignment, rotations, cross-bites, and other irregularities.
• Characteristics:
  • Molar relationship is normal.
  • Teeth may be crowded or rotated.
  • Other alignment irregularities may be present.

Class II Malocclusion (Distocclusion)

• Definition: The lower molar is positioned distal to the upper molar.
• Characteristics:
  • Often results in a retrognathic facial profile.
  • Increased overjet and overbite.
  • The mesiobuccal cusp of the maxillary first molar occludes anterior to the buccal groove of the mandibular first molar.

Subdivisions of Class II Malocclusion:

1. Class II Division 1:
   • Class II molars with normally inclined or proclined maxillary central incisors.
2. Class II Division 2:
   • Class II molars with retroclined maxillary central incisors.

Class III Malocclusion (Mesiocclusion)

• Definition: The lower molar is positioned mesial to the upper molar.
• Characteristics:
  • Often results in a prognathic facial profile.
  • Anterior crossbite and negative overjet (underbite).
  • The mesiobuccal cusp of the upper first molar falls posterior to the buccal groove of the lower first molar.

Advantages of Angle’s Classification

• Comprehensive: It is the first comprehensive classification and is widely accepted in the field of orthodontics.
• Simplicity: The classification is straightforward and easy to use.
• Popularity: It is the most popular classification system among orthodontists.
• Effective Communication: Facilitates clear communication regarding malocclusion.

Disadvantages of Angle’s Classification

• Limited Plane Consideration: It primarily considers malocclusion in the anteroposterior plane, neglecting transverse and vertical dimensions.
• Fixed Reference Point: The first molar is considered a fixed point, which may not be applicable in all cases.
• Not Applicable for Deciduous Dentition: The classification does not effectively address malocclusion in children with primary teeth.
• Lack of Distinction: It does not differentiate between skeletal and dental malocclusion.

Myofunctional Appliances

• Myofunctional appliances are removable or fixed devices that aim to correct dental and skeletal discrepancies by promoting proper oral and facial muscle function. They are based on the principles of myofunctional therapy, which focuses on the relationship between muscle function and dental alignment.

1. Mechanism of Action:

   • These appliances work by encouraging the correct positioning of the tongue, lips, and cheeks, which can help guide the growth of the jaws and the alignment of the teeth. They can also help in retraining oral muscle habits that may contribute to malocclusion, such as thumb sucking or mouth breathing.

Types of Myofunctional Appliances

1. Functional Appliances:

   • Bionator: A removable appliance that encourages forward positioning of the mandible and helps in correcting Class II malocclusions.
   • Frankel Appliance: A removable appliance that modifies the position of the dental arches and improves facial aesthetics by influencing muscle function.
   • Activator: A functional appliance that promotes mandibular growth and corrects dental relationships by positioning the mandible forward.

2. Tongue Retainers:

   • Devices designed to maintain the tongue in a specific position, often used to correct tongue thrusting habits that can lead to malocclusion.

3. Mouthguards:

   • While primarily used for protection during sports, certain types of mouthguards can also be designed to promote proper tongue posture and prevent harmful oral habits.

4. Myobrace:

   • A specific type of myofunctional appliance that is used to correct dental alignment and improve oral function by encouraging proper tongue posture and lip closure.

Indications for Use

• Malocclusions: Myofunctional appliances are often indicated for treating Class II and Class III malocclusions, as well as other dental alignment issues.
• Oral Habits: They can help in correcting harmful oral habits such as thumb sucking, tongue thrusting, and mouth breathing.
• Facial Growth Modification: These appliances can be used to influence the growth of the jaws in growing children, promoting a more favorable dental and facial relationship.
• Improving Oral Function: They can enhance functions such as chewing, swallowing, and speech by promoting proper muscle coordination.

Advantages of Myofunctional Appliances

1. Non-Invasive: Myofunctional appliances are generally non-invasive and can be a more comfortable option for patients compared to fixed appliances.
2. Promotes Natural Growth: They can guide the natural growth of the jaws and teeth, making them particularly effective in growing children.
3. Improves Oral Function: By retraining oral muscle function, these appliances can enhance overall oral health and function.
4. Aesthetic Appeal: Many myofunctional appliances are less noticeable than traditional braces, which can be more appealing to patients.

Limitations of Myofunctional Appliances

1. Compliance Dependent: The effectiveness of myofunctional appliances relies heavily on patient compliance. Patients must wear the appliance as prescribed for optimal results.
2. Limited Scope: While effective for certain types of malocclusions, myofunctional appliances may not be suitable for all cases, particularly those requiring significant tooth movement or surgical intervention.
3. Adjustment Period: Patients may experience discomfort or difficulty adjusting to the appliance initially, which can affect compliance.

Key Cephalometric Landmarks

1. Sella (S):

   • The midpoint of the sella turcica, a bony structure located at the base of the skull. It serves as a central reference point in cephalometric analysis.

2. Nasion (N):

   • The junction of the frontal and nasal bones, located at the bridge of the nose. It is often used as a reference point for the anterior cranial base.

3. A Point (A):

   • The deepest point on the maxillary arch, located between the anterior nasal spine and the maxillary alveolar process. It is crucial for assessing maxillary position.

4. B Point (B):

   • The deepest point on the mandibular arch, located between the anterior nasal spine and the mandibular alveolar process. It is important for evaluating mandibular position.

5. Pogonion (Pog):

   • The most anterior point on the contour of the chin. It is used to assess the position of the mandible in relation to the maxilla.

6. Gnathion (Gn):

   • The midpoint between Menton and Pogonion, representing the most inferior point of the mandible. It is used in various angular measurements.

7. Menton (Me):

   • The lowest point on the symphysis of the mandible. It is used as a reference for vertical measurements.

8. Go (Gonion):

   • The midpoint of the contour of the ramus and the body of the mandible. It is used to assess the angle of the mandible.

9. Frankfort Horizontal Plane (FH):

   • A plane defined by the points of the external auditory meatus (EAM) and the lowest point of the orbit (Orbitale). It is used as a reference plane for various measurements.

10. Orbitale (Or):

    • The lowest point on the inferior margin of the orbit (eye socket). It is used in conjunction with the EAM to define the Frankfort Horizontal Plane.

11. Ectocanthion (Ec):

    • The outer canthus of the eye, used in facial measurements and assessments.

12. Endocanthion (En):

    • The inner canthus of the eye, also used in facial measurements.

13. Alveolar Points:

    • Points on the alveolar ridge of the maxilla and mandible, often used to assess the position of the teeth.

Importance of Cephalometric Landmarks

• Diagnosis: These landmarks help orthodontists diagnose skeletal and dental discrepancies, such as Class I, II, or III malocclusions.
• Treatment Planning: By understanding the relationships between these landmarks, orthodontists can develop effective treatment plans tailored to the individual patient's needs.
• Monitoring Progress: Cephalometric landmarks allow for the comparison of pre-treatment and post-treatment radiographs, helping to evaluate the effectiveness of orthodontic interventions.
• Research and Education: These landmarks are essential in orthodontic research and education, providing a standardized method for analyzing craniofacial morphology.

Frankel appliance is a functional orthodontic device designed to guide facial growth and correct malocclusions. There are four main types: Frankel I (for Class I and Class II Division 1 malocclusions), Frankel II (for Class II Division 2), Frankel III (for Class III malocclusions), and Frankel IV (for specific cases requiring unique adjustments). Each type addresses different dental and skeletal relationships.

The Frankel appliance is a removable orthodontic device that plays a crucial role in the treatment of various malocclusions. It is designed to influence the growth of the jaw and dental arches by modifying muscle function and promoting proper alignment of teeth.

Types of Frankel Appliances

1. Frankel I:

   • Indications: Primarily used for Class I and Class II Division 1 malocclusions.
   • Function: Helps in correcting overjet and improving dental alignment.

2. Frankel II:

   • Indications: Specifically designed for Class II Division 2 malocclusions.
   • Function: Aims to reposition the maxilla and improve the relationship between the upper and lower teeth.

3. Frankel III:

   • Indications: Used for Class III malocclusions.
   • Function: Encourages forward positioning of the maxilla and helps in correcting the skeletal relationship.

4. Frankel IV:

   • Indications: Suitable for open bites and bimaxillary protrusions.
   • Function: Focuses on creating space and improving the occlusion by addressing specific dental and skeletal issues.

Key Features of Frankel Appliances

• Myofunctional Design: The appliance is designed to utilize the forces generated by muscle function to guide the growth of the dental arches.

• Removable: Patients can take the appliance out for cleaning and during meals, which enhances comfort and hygiene.

• Custom Fit: Each appliance is tailored to the individual patient's dental anatomy, ensuring effective treatment.

Treatment Goals

• Facial Balance: The primary goal of using a Frankel appliance is to achieve facial harmony and balance by correcting malocclusions.

• Functional Improvement: It promotes the establishment of normal muscle function, which is essential for long-term dental health.

• Arch Development: The appliance aids in the development of the dental arches, providing adequate space for the eruption of permanent teeth.

Steiner's Analysis

Steiner's analysis is a widely recognized cephalometric method used in orthodontics to evaluate the relationships between the skeletal and dental structures of the face. Developed by Dr. Charles A. Steiner in the 1950s, this analysis provides a systematic approach to assess craniofacial morphology and is particularly useful for treatment planning and evaluating the effects of orthodontic treatment.

Key Features of Steiner's Analysis

1. Reference Planes and Points:

   • Sella (S): The midpoint of the sella turcica, a bony structure in the skull.
   • Nasion (N): The junction of the frontal and nasal bones.
   • A Point (A): The deepest point on the maxillary arch between the anterior nasal spine and the maxillary alveolar process.
   • B Point (B): The deepest point on the mandibular arch between the anterior nasal spine and the mandibular alveolar process.
   • Menton (Me): The lowest point on the symphysis of the mandible.
   • Gnathion (Gn): The midpoint between Menton and Pogonion (the most anterior point on the chin).
   • Pogonion (Pog): The most anterior point on the contour of the chin.

2. Reference Lines:

   • SN Plane: A line drawn from Sella to Nasion, representing the cranial base.
   • ANB Angle: The angle formed between the lines connecting A Point to Nasion and B Point to Nasion. It indicates the relationship between the maxilla and mandible.
   • Facial Plane (FP): A line drawn from Gonion (Go) to Menton (Me), used to assess the facial profile.

3. Key Measurements:

   • ANB Angle: Indicates the anteroposterior relationship between the maxilla and mandible.
     • Normal Range: Typically between 2° and 4°.
   • SN-MP Angle: The angle between the SN plane and the mandibular plane (MP), which helps assess the vertical position of the mandible.
     • Normal Range: Usually between 32° and 38°.
   • Wits Appraisal: The distance between the perpendiculars dropped from points A and B to the occlusal plane. It provides insight into the anteroposterior relationship of the dental bases.

Clinical Relevance

• Diagnosis and Treatment Planning: Steiner's analysis helps orthodontists diagnose skeletal discrepancies and plan appropriate treatment strategies. It provides a clear understanding of the patient's craniofacial relationships, which is essential for effective orthodontic intervention.
• Monitoring Treatment Progress: By comparing pre-treatment and post-treatment cephalometric measurements, orthodontists can evaluate the effectiveness of the treatment and make necessary adjustments.
• Predicting Treatment Outcomes: The analysis aids in predicting the outcomes of orthodontic treatment by assessing the initial skeletal and dental relationships.