Talk to us?

- NEETMDS- courses
Oral and Maxillofacial Surgery

Coagulation Tests: PT and PTT

Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) are laboratory tests used to evaluate the coagulation pathways involved in blood clotting. Understanding these tests is crucial for diagnosing bleeding disorders and managing patients with specific factor deficiencies.

Prothrombin Time (PT)

  • Purpose: PT is primarily used to assess the extrinsic pathway of coagulation.
  • Factors Tested: It evaluates the function of factors I (fibrinogen), II (prothrombin), V, VII, and X.
  • Clinical Use: PT is commonly used to monitor patients on anticoagulant therapy (e.g., warfarin) and to assess bleeding risk before surgical procedures.

Partial Thromboplastin Time (PTT)

  • Purpose: PTT is used to assess the intrinsic pathway of coagulation.
  • Factors Tested: It evaluates the function of factors I (fibrinogen), II (prothrombin), V, VIII, IX, X, XI, and XII.
  • Clinical Use: PTT is often used to monitor patients on heparin therapy and to evaluate bleeding disorders.

Specific Factor Deficiencies

In certain bleeding disorders, specific factor deficiencies can lead to increased bleeding risk. Preoperative management may involve the administration of the respective clotting factors or antifibrinolytic agents to minimize bleeding during surgical procedures.

  1. Hemophilia A:

    • Deficiency: Factor VIII deficiency.
    • Management: Administration of factor VIII concentrate before surgery.
  2. Hemophilia B:

    • Deficiency: Factor IX deficiency.
    • Management: Administration of factor IX concentrate before surgery.
  3. Hemophilia C:

    • Deficiency: Factor XI deficiency.
    • Management: Administration of factor XI concentrate or fresh frozen plasma (FFP) may be considered.
  4. Von Willebrand’s Disease:

    • Deficiency: Deficiency or dysfunction of von Willebrand factor (vWF), which is important for platelet adhesion.
    • Management: Desmopressin (DDAVP) may be administered to increase vWF levels, or factor replacement therapy may be used.
  5. Antifibrinolytic Agent:

    • Aminocaproic Acid: This antifibrinolytic agent can be used to help stabilize clots and reduce bleeding during surgical procedures, particularly in patients with bleeding disorders.

Sliding Osseous Genioplasty

Sliding osseous genioplasty is a surgical technique designed to enhance the projection of the chin, thereby improving facial aesthetics. This procedure is particularly advantageous for patients with retrogathia, where the chin is positioned further back than normal, and who typically present with Class I occlusion (normal bite relationship) without significant dentofacial deformities.

Indications for Sliding Osseous Genioplasty

  1. Aesthetic Chin Surgery:

    • Most patients seeking this procedure do not have severe dentofacial deformities. They desire increased chin projection to achieve better facial balance and aesthetics.
  2. Retrogathia:

    • Patients with a receding chin can significantly benefit from sliding osseous genioplasty, as it allows for the forward repositioning of the chin.

Procedure Overview

Sliding Osseous Genioplasty involves several key steps:

  1. Surgical Technique:

    • Incision: The procedure can be performed through an intraoral incision (inside the mouth) or an extraoral incision (under the chin) to access the chin bone (mandibular symphysis).
    • Bone Mobilization: A horizontal osteotomy (cut) is made in the chin bone to create a movable segment. This allows the surgeon to slide the bone segment forward to increase chin projection.
    • Fixation: Once the desired position is achieved, the bone segment is secured in place using plates and screws or other fixation methods to maintain stability during the healing process.
  2. Versatility:

    • Shorter and Longer Advancements: The technique can be tailored to achieve both shorter and longer advancements of the chin, depending on the patient's aesthetic goals.
    • Vertical Height Alterations: Sliding osseous genioplasty is particularly effective for making vertical height adjustments to the chin, allowing for a customized approach to facial contouring.

Recovery

  • Postoperative Care:

    • Patients may experience swelling, bruising, and discomfort following the procedure. Pain relief medications are typically prescribed to manage discomfort.
    • A soft diet is often recommended during the initial recovery phase to minimize strain on the surgical site.
  • Follow-Up Appointments:

    • Regular follow-up visits are necessary to monitor healing, assess the alignment of the chin, and ensure that there are no complications.
    • The surgeon will evaluate the aesthetic outcome and make any necessary adjustments to the postoperative care plan.

Prognosis After Traumatic Brain Injury (TBI)

Determining the prognosis for patients after a traumatic brain injury (TBI) is a complex and multifaceted process. Several factors can influence the outcome, and understanding these variables is crucial for clinicians in managing TBI patients effectively. Below is an overview of the key prognostic indicators, with a focus on the Glasgow Coma Scale (GCS) and other factors that correlate with severity and outcomes.

Key Prognostic Indicators

  1. Glasgow Coma Scale (GCS):

    • The GCS is a widely used tool for assessing the level of consciousness in TBI patients. It evaluates three components: eye opening (E), best motor response (M), and verbal response (V).
    • Coma Score Calculation:
      • The total GCS score is calculated as follows: [ \text{Coma Score} = E + M + V ]
    • Prognostic Implications:
      • Scores of 3-4: Patients scoring in this range have an 85% chance of dying or remaining in a vegetative state.
      • Scores of 11 or above: Patients with scores in this range have only a 5-10% chance of dying or remaining vegetative.
      • Intermediate Scores: Scores between these ranges correlate with proportional chances of recovery, indicating that higher scores generally predict better outcomes.
  2. Other Poor Prognosis Indicators:

    • Older Age: Age is a significant factor, with older patients generally having worse outcomes following TBI.
    • Increased Intracranial Pressure (ICP): Elevated ICP is associated with poorer outcomes, as it can lead to brain herniation and further injury.
    • Hypoxia and Hypotension: Both conditions can exacerbate brain injury and are associated with worse prognoses.
    • CT Evidence of Compression: Imaging findings such as compression of the cisterns or midline shift indicate significant mass effect and are associated with poor outcomes.
    • Delayed Evacuation of Large Intracerebral Hemorrhage: Timely surgical intervention is critical; delays can worsen the prognosis.
    • Carrier Status for Apolipoprotein E-4 Allele: The presence of this allele has been linked to poorer outcomes in TBI patients, suggesting a genetic predisposition to worse recovery.

Surgical Considerations for the Submandibular and Parotid Glands

When performing surgery on the submandibular and parotid glands, it is crucial to be aware of the anatomical structures and nerves at risk to minimize complications. Below is an overview of the key nerves and anatomical landmarks relevant to these surgical procedures.

Major Nerves at Risk During Submandibular Gland Surgery

  1. Hypoglossal Nerve (CN XII):

    • This nerve is responsible for motor innervation to the muscles of the tongue. It lies deep to the submandibular gland and is at risk during surgical manipulation in this area.
  2. Marginal Mandibular Nerve:

    • A branch of the facial nerve (CN VII), the marginal mandibular nerve innervates the muscles of the lower lip and chin. It runs just deep to the superficial layer of the deep cervical fascia, below the platysma muscle, making it vulnerable during submandibular gland surgery.
  3. Lingual Nerve:

    • The lingual nerve provides sensory innervation to the anterior two-thirds of the tongue and carries parasympathetic fibers to the submandibular gland via the submandibular ganglion. It is located in close proximity to the submandibular gland and is at risk during dissection.

Anatomical Considerations for Parotid Gland Surgery

  • Parotid Fascia:

    • The parotid gland is encased in a capsule of parotid fascia, which provides a protective layer during surgical procedures.
  • Facial Nerve (CN VII):

    • The facial nerve is a critical structure to identify during parotid gland surgery to prevent injury. Key landmarks for locating the facial nerve include:
      • Tympanomastoid Suture Line: This is a reliable landmark for identifying the main trunk of the facial nerve, which lies just deep and medial to this suture.
      • Tragal Pointer: The nerve is located about 1 cm deep and inferior to the tragal pointer, although this landmark is less reliable.
      • Posterior Belly of the Digastric Muscle: This muscle provides a reference for the approximate depth of the facial nerve.
      • Peripheral Buccal Branches: While following these branches can help identify the nerve, this should not be the standard approach due to the risk of injury.

Submandibular Gland Anatomy

  • Location:

    • The submandibular gland is situated in the submandibular triangle of the neck, which is bordered by the mandible and the digastric muscles.
  • Mylohyoid Muscle:

    • The gland wraps around the mylohyoid muscle, which is typically retracted anteriorly during surgery to provide better exposure of the gland.
  • CN XII:

    • The hypoglossal nerve lies deep to the submandibular gland, making it important to identify and protect during surgical procedures.

Le Fort I Fracture

  • A horizontal fracture that separates the maxilla from the nasal and zygomatic bones. It is also known as a "floating maxilla."

Signs and Symptoms:

  1. Bilateral Periorbital Edema and Ecchymosis: Swelling and bruising around the eyes (Raccoon eyes).
  2. Disturbed Occlusion: Malocclusion due to displacement of the maxilla.
  3. Mobility of the Maxilla: The maxilla may move independently of the rest of the facial skeleton.
  4. Nasal Bleeding: Possible epistaxis due to injury to the nasal mucosa.
  5. CSF Rhinorrhea: If there is a breach in the dura mater, cerebrospinal fluid may leak from the nose.

Le Fort II Fracture

  • A pyramidal fracture that involves the maxilla, nasal bones, and the zygomatic bones. It is characterized by a fracture line that extends from the nasal bridge to the maxilla and zygomatic arch.

Signs and Symptoms:

  1. Bilateral Periorbital Edema and Ecchymosis: Swelling and bruising around the eyes (Raccoon eyes).
  2. Diplopia: Double vision due to involvement of the orbital floor and potential muscle entrapment.
  3. Enophthalmos: Posterior displacement of the eyeball within the orbit.
  4. Restriction of Globe Movements: Limited eye movement due to muscle entrapment.
  5. Disturbed Occlusion: Malocclusion due to displacement of the maxilla.
  6. Nasal Bleeding: Possible epistaxis.
  7. CSF Rhinorrhea: If the dura is torn, cerebrospinal fluid may leak from the nose.

Le Fort III Fracture

  • A craniofacial disjunction fracture that involves the maxilla, zygomatic bones, and the orbits. It is characterized by a fracture line that separates the entire midface from the skull base.

Signs and Symptoms:

  1. Bilateral Periorbital Edema and Ecchymosis: Swelling and bruising around the eyes (Raccoon eyes).
  2. Orbital Dystopia: Abnormal positioning of the orbits, often with an antimongoloid slant.
  3. Diplopia: Double vision due to muscle entrapment or damage.
  4. Enophthalmos: Posterior displacement of the eyeball.
  5. Restriction of Globe Movements: Limited eye movement due to muscle entrapment.
  6. Disturbed Occlusion: Significant malocclusion due to extensive displacement of facial structures.
  7. CSF Rhinorrhea: If there is a breach in the dura mater, cerebrospinal fluid may leak from the nose or ears (CSF otorrhea).
  8. Bleeding Over Mastoid Process (Battle’s Sign): Bruising behind the ear may indicate a skull base fracture.

Tests for Efficiency in Heat Sterilization – Sterilization Monitoring

Effective sterilization is crucial in healthcare settings to ensure the safety of patients and the efficacy of medical instruments. Various monitoring techniques are employed to evaluate the sterilization process, including mechanical, chemical, and biological parameters. Here’s an overview of these methods:

1. Mechanical Monitoring

  • Parameters Assessed:

    • Cycle Time: The duration of the sterilization cycle.
    • Temperature: The temperature reached during the sterilization process.
    • Pressure: The pressure maintained within the sterilizer.
  • Methods:

    • Gauges and Displays: Observing the gauges or digital displays on the sterilizer provides real-time data on the cycle parameters.
    • Recording Devices: Some tabletop sterilizers are equipped with recording devices that print out the cycle parameters for each load.
  • Interpretation:

    • While correct readings indicate that the sterilization conditions were likely met, incorrect readings can signal potential issues with the sterilizer, necessitating further investigation.

2. Biological Monitoring

  • Spore Testing:
    • Biological Indicators: This involves using spore strips or vials containing Geobacillus stearothermophilus, a heat-resistant bacterium.
    • Frequency: Spore testing should be conducted weekly to verify the proper functioning of the autoclave.
    • Interpretation: If the spores are killed after the sterilization cycle, it confirms that the sterilization process was effective.

3. Thermometric Testing

  • Thermocouple:
    • A thermocouple is used to measure temperature at two locations:
      • Inside a Test Pack: A thermocouple is placed within a test pack of towels to assess the temperature reached in the center of the load.
      • Chamber Drain: A second thermocouple measures the temperature at the chamber drain.
    • Comparison: The readings from both locations are compared to ensure that the temperature is adequate throughout the load.

4. Chemical Monitoring

  • Brown’s Test:

    • This test uses ampoules containing a chemical indicator that changes color based on temperature.
    • Color Change: The indicator changes from red through amber to green at a specific temperature, confirming that the required temperature was reached.
  • Autoclave Tape:

    • Autoclave tape is printed with sensitive ink that changes color when exposed to specific temperatures.
    • Bowie-Dick Test: This test is a specific application of autoclave tape, where two strips are placed on a piece of square paper and positioned in the center of the test pack.
    • Test Conditions: When subjected to a temperature of 134°C for 3.5 minutes, uniform color development along the strips indicates that steam has penetrated the load effectively.

Management of Mandibular Fractures: Plate Fixation Techniques

The management of mandibular fractures involves various techniques for fixation, depending on the type and location of the fracture. .

1. Plate Placement in the Body of the Mandible

  • Single Plate Fixation:

    • A single plate is recommended to be placed just below the apices of the teeth but above the inferior alveolar nerve canal. This positioning helps to avoid damage to the nerve while providing adequate support to the fracture site.
    • Miniplate Fixation: Effective for non-displaced or minimally displaced fractures, provided the fracture is not severely comminuted. The miniplate should be placed at the superior border of the mandible, acting as a tension band that prevents distraction at the superior border while maintaining compression at the inferior border during function.
  • Additional Plates:

    • While a solitary plate can provide adequate rigidity, the placement of an additional plate or the use of multi-armed plates (Y or H plates) can enhance stability, especially in more complex fractures.

2. Plate Placement in the Parasymphyseal and Symphyseal Regions

  • Two Plates for Stability:

    • In the parasymphyseal and symphyseal regions, two plates are recommended due to the torsional forces generated during function.
      • First Plate: Placed at the inferior aspect of the mandible.
      • Second Plate: Placed parallel and at least 5 mm superior to the first plate (subapical).
  • Plate Placement Behind the Mental Foramen:

    • A plate can be fixed in the subapical area and another near the lower border. Additionally, plates can be placed on the external oblique ridge or parallel to the lower border of the mandible.

3. Management of Comminuted or Grossly Displaced Fractures

  • Reconstruction Plates:
    • Comminuted or grossly displaced fractures of the mandibular body require fixation with a locking reconstruction plate or a standard reconstruction plate. These plates provide the necessary stability for complex fractures.

4. Management of Mandibular Angle Fractures

  • Miniplate Fixation:
    • When treating mandibular angle fractures, the plate should be placed at the superolateral aspect of the mandible, extending onto the broad surface of the external oblique ridge. This placement helps to counteract the forces acting on the angle of the mandible.

5. Stress Patterns and Plate Design

  • Stress Patterns:

    • The zone of compression is located at the superior border of the mandible, while the neutral axis is approximately at the level of the inferior alveolar canal. Understanding these stress patterns is crucial for optimal plate placement.
  • Miniplate Characteristics:

    • Developed by Michelet et al. and popularized by Champy et al., miniplates utilize monocortical screws and require a minimum of two screws in each osseous segment. They are smaller than standard plates, allowing for smaller incisions and less soft tissue dissection, which reduces the risk of complications.

6. Other Fixation Techniques

  • Compression Osteosynthesis:

    • Indicated for non-oblique fractures that demonstrate good body opposition after reduction. Compression plates, such as dynamic compression plates (DCP), are used to achieve this. The inclined plate within the hole allows for translation of the bone toward the fracture site as the screw is tightened.
  • Fixation Osteosynthesis:

    • For severely oblique fractures, comminuted fractures, and fractures with bone loss, compression plates are contraindicated. In these cases, non-compression osteosynthesis using locking plates or reconstruction plates is preferred. This method is also suitable for patients with questionable postoperative compliance or a non-stable mandible.

Explore by Exams