Anomalies of Number: problems in initiation stage

 Hypodontia: 6% incidence; usually autosomal dominant (50% chance of passing to children) with variable expressivity (e.g., parent has mild while child has severe); most common missing permanent tooth (excluding 3rd molars) is Md 2nd premolar, 2nd most common is X lateral; oligodontia (at least 6 missing), and anodontia

1. Clincial implications: can interfere with function, lack of teeth → ↓ alveolar bone formation, esthetics, hard to replace in young children, implants only after growth completed, severe cases should receive genetic and systemic evaluation to see if other problems

2. Syndromes with hypodontia: Rieger syndrome, incontinentia pigmenti, Kabuki syndrome, Ellis-van Creveld syndrome, epidermolysis bullosa junctionalis, and ectodermal dysplasia (usually X-linked; sparse hair, unable to sweat, dysplastic nails)

Supernumerary teeth: aka hyperdontia; mesiodens when located in palatal midline; occur sporadically or as part of syndrome, common in cleft cases; delayed eruption often a sign that supernumeraries are preventing normal eruption

1. Multiple supernumerary teeth: cleidocranial dysplasia/dysostosis, Down’s, Apert, and Crouzon syndromes, etc.

Anomalies of Size: problems in morphodifferentiation stage

Microdontia: most commonly peg laterals; also in Down’s syndrome, hemifacial microsomia

Macrodontia: may be associated with hemifacial hypertrophy

Fusion: more common in primary dentition; union of two developing teeth

Gemination: more common in primary; incomplete division of single tooth bud → bifid crown, one pulp chamber; clinically distinguish from fusion by counting geminated tooth as one and have normal # teeth present (not in fusion)

 Anomalies of Shape: errors during morphodifferentiation stage

Dens evaginatus: extra cusp in central groove/cingulum; fracture can → pulp exposure; most common in Orientals

Dens in dente: invagination of inner enamel epithelium → appearance of tooth within a tooth

Taurodontism: failure of Hertwig’s epithelial root sheath to invaginate to proper level → elongated (deep) pulp chamber, stunted roots; sporadic or associated with syndrome (e.g., amelogenesis imperfecta, Trichodento-osseous syndrome, ectodermal dysplasia)

Conical teeth: often associated with ectodermal dysplasia

Anomalies of Structure: problems during histodifferentiation, apposition, and mineralization stages

Dentinogenesis imperfecta: problem during histodifferentiation where defective dentin matrix → disorganized and atubular circumpulpal dentin; autosomal dominant inheritance; three types, one occurs with osteogenesis imperfecta (brittle bone syndrome); not sensitive despite exposed dentin; primary dentition has bulbous crowns, obliterated pulp chambers, bluish-grey or brownish-yellow teeth that are easily worn; permanent teeth often stained but can be sound

Amelogenesis imperfecta: heritable defect, independent from metabolic, syndromes, or systemic conditions (though similar defects seen with syndromes or environmental insults); four main types (hypoplastic, hypocalcified, hypomaturation, hypoplastic/hypomaturation with taurodontism); proper treatment addresses sensitivity, esthetics, VDO, caries and gingivitis prevention

Enamel hypoplasia: quantitative defect of enamel from problems in apposition stage; localized (caused by trauma) or generalized (caused by infection, metabolic disease, malnutrition, or hereditary disorders) effects; more common in malnourished children; least commonly Md incisors affected, often 1st molars; more susceptible to caries, excessive wearing → lost VDO, esthetic problems, and sensitivity to hot/cold

Enamel hypocalcification: during calcification stage

Fluorosis: excess F ingestion during calcification stage → intrinsic stain, mottled appearance, or brown staining and pitting; mild, moderate, or severe; porous enamel soaks up external stain

Anti-Infective and Anticariogenic Agents in Human Milk

Human milk is not only a source of nutrition for infants but also contains various bioactive components that provide anti-infective and anticariogenic properties. These components play a crucial role in protecting infants from infections and promoting oral health. Below are the key agents found in human milk:

1. Immunoglobulins

• Secretory IgA: The predominant immunoglobulin in human milk, secretory IgA plays a vital role in mucosal immunity by preventing the attachment of pathogens to mucosal surfaces.
• IgG and IgM: These immunoglobulins also contribute to the immune defense, with IgG providing systemic immunity and IgM being involved in the initial immune response.

2. Cellular Elements

• Lymphoid Cells: These cells are part of the immune system and help in the recognition and response to pathogens.
• Polymorphonuclear Leukocytes (Polymorphs): These white blood cells are essential for the innate immune response, helping to engulf and destroy pathogens.
• Macrophages: These cells play a critical role in phagocytosis and the immune response, helping to clear infections.
• Plasma Cells: These cells produce antibodies, contributing to the immune defense.

3. Complement System

• C3 and C4 Complement Proteins: These components of the complement system have opsonic and chemotactic activities, enhancing the ability of immune cells to recognize and eliminate pathogens. They promote inflammation and attract immune cells to sites of infection.

4. Unsaturated Lactoferrin and Transferrin

• Lactoferrin: This iron-binding protein has antimicrobial properties, inhibiting the growth of bacteria and fungi by depriving them of iron.
• Transferrin: Similar to lactoferrin, transferrin also binds iron and plays a role in iron metabolism and immune function.

5. Lysozyme

• Function: Lysozyme is an enzyme that breaks down bacterial cell walls, providing antibacterial activity. It helps protect the infant from bacterial infections.

6. Lactoperoxidase

• Function: This enzyme produces reactive oxygen species that have antimicrobial effects, contributing to the overall antibacterial properties of human milk.

7. Specific Inhibitors (Non-Immunoglobulins)

• Antiviral and Antistaphylococcal Factors: Human milk contains specific factors that inhibit viral infections and the growth of Staphylococcus bacteria, providing additional protection against infections.

8. Growth Factors for Lactobacillus Bifidus

• Function: Human milk contains growth factors that promote the growth of beneficial bacteria such as Lactobacillus bifidus, which plays a role in maintaining gut health and preventing pathogenic infections.

9. Para-Aminobenzoic Acid (PABA)

• Function: PABA may provide some protection against malaria, highlighting the potential role of human milk in offering broader protective effects against various infections.

Erikson's Eight Stages of Psychosocial Development

1. Basic Trust versus Basic Mistrust (Hope):

   • Age: Infants (0-1 year)
   • Description: In this stage, infants learn to trust their caregivers and the world around them. Consistent and reliable care leads to a sense of security.
   • Positive Outcome: If caregivers provide reliable care and affection, the infant develops a sense of trust, leading to feelings of safety and hope.
   • Negative Outcome: Inconsistent or neglectful care can result in mistrust, leading to anxiety and insecurity.

2. Autonomy versus Shame and Doubt (Will):

   • Age: Toddlers (1-2 years)
   • Description: As toddlers begin to explore their environment and assert their independence, they face the challenge of developing autonomy.
   • Positive Outcome: Encouragement and support from caregivers foster a sense of autonomy and confidence in their abilities.
   • Negative Outcome: Overly critical or controlling caregivers can lead to feelings of shame and doubt about their abilities.

3. Initiative versus Guilt (Purpose):

   • Age: Early Childhood (2-6 years)
   • Description: Children begin to initiate activities, assert control over their environment, and develop a sense of purpose.
   • Positive Outcome: When children are encouraged to take initiative, they develop a sense of purpose and leadership.
   • Negative Outcome: If their initiatives are met with criticism or discouragement, they may develop feelings of guilt and inhibition.

4. Industry versus Inferiority (Competence):

   • Age: Elementary and Middle School (6-12 years)
   • Description: Children learn to work with others and develop skills and competencies. They begin to compare themselves to peers.
   • Positive Outcome: Success in school and social interactions fosters a sense of competence and achievement.
   • Negative Outcome: Failure to succeed or negative comparisons can lead to feelings of inferiority and a lack of self-worth.

5. Identity versus Role Confusion (Fidelity):

   • Age: Adolescence (12-18 years)
   • Description: Adolescents explore their personal identity, values, and beliefs, seeking to establish a sense of self.
   • Positive Outcome: Successful exploration leads to a strong sense of identity and fidelity to one's beliefs and values.
   • Negative Outcome: Failure to establish a clear identity can result in role confusion and uncertainty about one's place in the world.

6. Intimacy versus Isolation (Love):

   • Age: Young Adulthood (19-40 years)
   • Description: Young adults seek to form intimate relationships and connections with others.
   • Positive Outcome: Successful relationships lead to deep connections and a sense of love and belonging.
   • Negative Outcome: Fear of intimacy or failure to form meaningful relationships can result in feelings of isolation and loneliness.

7. Generativity versus Stagnation (Care):

   • Age: Middle Adulthood (40-65 years)
   • Description: Adults strive to contribute to society and support the next generation, often through parenting, work, or community involvement.
   • Positive Outcome: A sense of generativity leads to feelings of productivity and fulfillment.
   • Negative Outcome: Failure to contribute can result in stagnation and a sense of unfulfillment.

8. Integrity versus Despair (Wisdom):

   • Age: Late Adulthood (65 years to death)
   • Description: Older adults reflect on their lives and evaluate their experiences.
   • Positive Outcome: A sense of integrity arises from a life well-lived, leading to feelings of wisdom and acceptance.
   • Negative Outcome: Regret over missed opportunities or unresolved conflicts can lead to despair and dissatisfaction with life.

Classification of Early Childhood Caries (ECC)

• Type 1 ECC (Mild to Moderate)

  • Affects molars and incisors
  • Typically seen in children aged 2-5 years

• Type 2 ECC (Moderate to Severe)

  • Characterized by labiolingual caries affecting maxillary incisors, with or without molar involvement
  • Usually observed soon after the first tooth erupts
  • Mandibular incisors remain unaffected
  • Often caused by inappropriate bottle feeding

• Type 3 ECC (Severe)

  • Involves all primary teeth
  • Commonly seen in children aged 3-5 years 

Degrees of Mental Disability

Mental disabilities are often classified based on the severity of cognitive impairment, which can be assessed using various intelligence scales, such as the Wechsler Intelligence Scale and the Stanford-Binet Scale. Below is a detailed overview of the degrees of mental disability, including IQ ranges and communication abilities.

1. Mild Mental Disability

• IQ Range: 55-69 (Wechsler Scale) or 52-67 (Stanford-Binet Scale)
• Description:
  • Individuals in this category may have some difficulty with academic skills but can often learn basic academic and practical skills.
  • They typically can communicate well enough for most communication needs and may function independently with some support.
  • They may have social skills that allow them to interact with peers and participate in community activities.

2. Moderate Mental Disability

• IQ Range: 40-54 (Wechsler Scale) or 36-51 (Stanford-Binet Scale)
• Description:
  • Individuals with moderate mental disability may have significant challenges in academic learning and require more support in daily living.
  • Communication skills may be limited; they can communicate at a basic level with others but may struggle with more complex language.
  • They often need assistance with personal care and may benefit from structured environments and support.

3. Severe or Profound Mental Disability

• IQ Range: 39 and below (Severe) or 35 and below (Profound)
• Description:
  • Individuals in this category have profound limitations in cognitive functioning and adaptive behavior.
  • Communication may be very limited; some may be mute or communicate only in grunts or very basic sounds.
  • They typically require extensive support for all aspects of daily living, including personal care and communication.