What is the primary mechanism by which proteinuria occurs in minimal-change disease?
1) Increased glomerular permeability due to alterations in the glomerular basement membrane
2) Immune complex deposition in the glomeruli
3) Alteration in the podocyte slit diaphragm
4) Reduced synthesis of plasma proteins
📝 Explanation:
In minimal-change disease, the primary mechanism of proteinuria is thought to be increased permeability of the glomerular capillary wall to proteins due to changes in the glomerular basement membrane, rather than structural damage to the membrane itself.