What is the principle behind the Prausnitz and Kustner experiment demonstrating IgE-mediated type I hypersensitivity?
1) Injection of allergen into a non-allergic person causes an allergic reaction.
2) Transfer of serum containing allergen-specific IgE from an allergic person to a non-allergic person induces an allergic reaction.
3) Introduction of allergen-specific T cells into a non-allergic person induces an allergic reaction.
4) Exposure of a non-allergic person to high doses of an allergen induces tolerance.
📝 Explanation:
the Prausnitz and Kustner experiment demonstrated Transfer of serum containing allergen-specific IgE from an allergic person to a non-allergic person induces an allergic reaction. This experiment showed that the allergic state is mediated by a serum component, which we now know is the immunoglobulin E (IgE), and that it can be passively transferred from one individual to another.
MCQ