In a patient with suspected hyperparathyroidism, which of the following is the most sensitive diagnostic test for the disease?
(1) Serum calcium
(2) Serum intact parathyroid hormone (iPTH)
(3) Urinary calcium-to-creatinine ratio
(4) Serum phosphorus
📝 Explanation:
The most sensitive diagnostic test for hyperparathyroidism is the measurement of serum intact parathyroid hormone (iPTH) levels. Elevated iPTH levels in the context of hypercalcemia are indicative of primary hyperparathyroidism. However, serum calcium levels are also typically high in this condition and are commonly measured in the initial workup.