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Public Health Dentistry - 3 Questions
Daily fluoride mouth rinse containing 0.05% sodium fluoride has a concentration of about 225 ppm fluoride ions 0.05% sodium fluoride solution = 225 ppm fluoride 0.2% sodium fluoride solution = 900 ppm fluoride The daily rinse (0.05%) is recommended for children aged 6–12 years. The weekly rinse (0.2%) is recommended for older children and adults at higher risk of caries.
Pit and fissure caries are initiated by the accumulation of food debris and bacteria in deep, narrow fissures and pits on the tooth surface, which are protected from the normal cleansing mechanisms of the mouth, even in the absence of a thick, mature dental plaque biofilm. Plaque is necessary for the initiation of proximal, smooth surface, and root surface caries.
The number of patients required in a clinical trial to treat a specify disease increases as:
1. the incidence of the disease decreases.2. the significance level increases.3. the size of the expected treatment effect increased.4. the drop-out rate increases.
A higher drop-out rate can reduce the power of a study, as it leads to a smaller sample size and potentially less reliable results. To maintain the statistical significance and power of the study, a larger sample size must be enrolled initially to account for the expected number of participants who will not complete the study. Other factors that influence sample size include the incidence of the disease, the significance level, and the size of the expected treatment effect, but the question specifically asks about the impact of an increasing drop-out rate.