In which type of nerve fibres is sensitivity to local anaesthetics greater?
1) Type B fibres
2) Type C fibres
3) Type A‑delta fibres
4) Fibres supplying the muscle spindles
📝 Explanation:
Local anaesthetics act by blocking voltage‑gated sodium
channels, preventing depolarization and conduction of nerve impulses.
The sensitivity of different nerve fibres depends on their diameter,
myelination, and conduction velocity.
Local anaesthetics preferentially block small,
unmyelinated fibres first (Type C), followed by small myelinated fibres
(Type B, A‑delta). Large myelinated fibres (A‑alpha) are blocked last. This
explains why pain sensation is lost before motor function during local
anaesthesia.