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pathology - 3 Questions

1
Pathology

Extensive cellulitis is known as:
1. Phlegm
2. Phlegmon
3. Cellulitis majora
4. Cellulitis prima

πŸ“ Explanation:

Extensive cellulitis is most accurately described by the term "phlegmon

Phlegm is a thick, viscous substance produced by the respiratory tract, especially during a respiratory infection, which can be coughed up from the lungs or expelled from the nose. It is primarily composed of mucus, dead cells, and other substances.

Phlegmon is a term that is closely related to extensive cellulitis. It refers to a severe form of cellulitis where the infection has spread deeply into the subcutaneous tissues and is accompanied by significant inflammation, including the presence of pus and necrosis. Phlegmon is characterized by intense pain, swelling, redness, and warmth in the affected area. This condition often requires aggressive medical management, including intravenous antibiotics and surgical drainage if an abscess forms. It is an advanced and severe stage of cellulitis that can lead to systemic infection if not treated properly.

2
Pathology

Most common areas of body susceptible to carcinomas:
1. Head and neck
2. Back
3. Pelvic and urogenital
4. Extremities

πŸ“ Explanation:

Head and Neck: The head and neck region includes various structures such as the oral cavity, nasal cavity, pharynx, larynx, and the salivary glands. This region is highly susceptible to carcinomas due to the presence of mucosal surfaces exposed to potential carcinogens. Common types of head and neck carcinomas include:

- Oral Squamous Cell Carcinoma: This is the most common form of head and neck cancer, typically occurring on the tongue, lips, oral cavity, and oropharynx. Risk factors include tobacco use (smoking and smokeless), alcohol consumption, and human papillomavirus (HPV) infection.
- Nasopharyngeal Carcinoma: This cancer arises from the nasopharynx and is often associated with environmental factors such as the Epstein-Barr virus (EBV) infection and dietary habits.
- Laryngeal Carcinoma: Cancer of the larynx (voice box) is often linked to smoking and excessive alcohol intake.

3
Pathology

A malignant tumour cell moves through the stages of:
1. Progression ¨ vascularization ¨ invasion ¨ detachment ¨ embolization
2. Vascularization ¨ invasion ¨ prepression ¨ detachment ¨ embolization
3. invasion¨ vascularization¨progression ¨ detachment ¨ embolization
4. Detachment ¨invasion ¨ vascularization ¨ progression ¨ embolization

πŸ“ Explanation:

The correct answer is: 1. Progression ¨ vascularization ¨ invasion ¨ detachment ¨ embolization.

Explanation of the stages for a malignant tumor cell:

1. Progression: This is the initial stage of tumor development where the cells acquire the ability to proliferate in an uncontrolled manner. This can be due to genetic mutations that alter the normal regulatory mechanisms that control cell division. The tumor grows locally within the tissue or organ of origin.

2. Vascularization: Also known as angiogenesis, this stage involves the formation of new blood vessels that supply the tumor with nutrients and oxygen, which is essential for its continued growth and progression. The tumor cells secrete factors that stimulate the growth of blood vessels into the tumor mass.

3. Invasion: The malignant tumor cells develop the capability to invade surrounding tissues. They secrete enzymes that degrade the extracellular matrix and basement membrane, allowing them to move through these barriers and invade neighboring tissues and organs.

4. Detachment: During this stage, tumor cells detach from the primary tumor site. This is facilitated by the loss of cell-to-cell adhesion molecules and the degradation of the extracellular matrix by proteolytic enzymes.

5. Embolization: Detached tumor cells can then enter the lymphatic system or bloodstream. This process is known as intravasation. They travel through these vessels as emboli and can potentially form new tumors at distant sites, which is the process of metastasis.

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